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Navone, N.M.; Polo, C.F.; Frisardi, A.L.; Batlle, A.M.D.C. "Mouse mammary carcinoma δ-aminolevulinate dehydratase" (1990) Comparative Biochemistry and Physiology -- Part B: Biochemistry and. 96(4):729-731
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Abstract:

1. 1. Aminolevulinate dehydratase (ALA-D) was studied in crude extract from mouse mammary carcinoma, normal mouse liver and tumour bearing mouse liver. 2. 2. A Michaelis-Menten behaviour and Km values between 0.24 and 0.31 mM were obtained for the enzyme in either source. 3. 3. In all three tissues there was a linear relationship between porphobilinogen formation and incubation time, up to 120 min, ALA-D was thermostable and optimum pH was at 6.8. 4. 4. There seems to be no structural alterations in tumoural ALA-D as compared with the enzyme from liver of both normal and tumour bearing mice. © 1990.

Registro:

Documento: Artículo
Título:Mouse mammary carcinoma δ-aminolevulinate dehydratase
Autor:Navone, N.M.; Polo, C.F.; Frisardi, A.L.; Batlle, A.M.D.C.
Filiación:Centro de Investigaciones sobre Porfirinas y Porfirias (CIPYP), Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires (UBA), Argentina
Palabras clave:liver enzyme; porphobilinogen synthase; animal cell; article; breast cancer; enzyme kinetics; mouse; nonhuman; priority journal; Animal; Enzyme Stability; Heat; Hydrogen-Ion Concentration; Kinetics; Liver; Male; Mammary Neoplasms, Experimental; Mice; Mice, Inbred BALB C; Porphobilinogen; Porphobilinogen Synthase; Support, Non-U.S. Gov't; Animalia
Año:1990
Volumen:96
Número:4
Página de inicio:729
Página de fin:731
DOI: http://dx.doi.org/10.1016/0305-0491(90)90221-E
Título revista:Comparative Biochemistry and Physiology -- Part B: Biochemistry and
ISSN:03050491
CAS:Porphobilinogen Synthase, EC 4.2.1.24; Porphobilinogen, 487-90-1
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03050491_v96_n4_p729_Navone

Referencias:

  • Batlle, Ferramola, Grinstein, Purification and general properties of δ-aminolevulinate dehydratase from cow liver (1967) Biochem. J., 104, pp. 244-249
  • Coleman, Purification and properties of delta-aminolevulinic acid dehydratase from tissues of two strains of mice (1966) J. biol. Chem., 241, pp. 5511-5520
  • Doyle, Subunit structure of δ-aminolevulinate dehydratase from mouse liver (1971) J. biol. Chem., 246, pp. 4965-4972
  • Doyle, Schimke, Genetic and developmental regulation of hepatic δ-aminolevulinate dehydratase in mice (1969) J. biol. Chem., 244, pp. 5449-5559
  • Jordan, Gibbs, Mechanism of action of 5-aminolaevulinate dehydratase from human erythrocytes (1985) Biochem. J., 227, pp. 1015-1020
  • Lowry, Rosebrough, Farr, Randall, Protein measurement with the Folin-phenol reagent (1951) J. biol. Chem., 193, pp. 265-275
  • Navone, Frisardi, Resnik, Batlle, Polo, Porphyrin biosynthesis in human breast cancer (1988) Preliminary mimetic in vitro studies, 16, pp. 61-62. , Med. Sci. Res
  • Rasetti, Rubino, Drago, Ferrochelatase, ALA-dehydrase and ALA-synthetase in human tumour tissue (1967) PanMinerva Med., 8, pp. 132-135
  • Stout, Becker, Heme enzyme patterns in genetically and chemically induced mouse liver tumors (1986) Cancer Res., 46, pp. 2756-2759
  • Stout, Becker, Heme enzyme patterns in rat liver nodules and tumors (1987) Cancer Res., 47, pp. 963-966
  • Takaku, Wada, Heme synthesis in normal and leukemic leukocytes (1968) Cancer Res., 28, pp. 1250-1255
  • Tigier, Batlle, Locascio, Porphyrin biosynthesis in soybean callus tissue system (1968) Isolation, purification and general properties of δ-aminolevulinate dehydratase, 151, pp. 300-302. , Biochim. biophys. Acta
  • Wilson, Burger, Dowdle, Beef liver δ-aminolevulinic acid dehydratase (1972) Eur. J. Biochem., 29, pp. 563-571

Citas:

---------- APA ----------
Navone, N.M., Polo, C.F., Frisardi, A.L. & Batlle, A.M.D.C. (1990) . Mouse mammary carcinoma δ-aminolevulinate dehydratase. Comparative Biochemistry and Physiology -- Part B: Biochemistry and, 96(4), 729-731.
http://dx.doi.org/10.1016/0305-0491(90)90221-E
---------- CHICAGO ----------
Navone, N.M., Polo, C.F., Frisardi, A.L., Batlle, A.M.D.C. "Mouse mammary carcinoma δ-aminolevulinate dehydratase" . Comparative Biochemistry and Physiology -- Part B: Biochemistry and 96, no. 4 (1990) : 729-731.
http://dx.doi.org/10.1016/0305-0491(90)90221-E
---------- MLA ----------
Navone, N.M., Polo, C.F., Frisardi, A.L., Batlle, A.M.D.C. "Mouse mammary carcinoma δ-aminolevulinate dehydratase" . Comparative Biochemistry and Physiology -- Part B: Biochemistry and, vol. 96, no. 4, 1990, pp. 729-731.
http://dx.doi.org/10.1016/0305-0491(90)90221-E
---------- VANCOUVER ----------
Navone, N.M., Polo, C.F., Frisardi, A.L., Batlle, A.M.D.C. Mouse mammary carcinoma δ-aminolevulinate dehydratase. 1990;96(4):729-731.
http://dx.doi.org/10.1016/0305-0491(90)90221-E