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Abstract:

When a consolidated memory is reactivated, it can become labile and prone to enhancement or disruption, a process known as reconsolidation. The reconsolidation hypothesis has challenged the traditional view that memories after consolidation are fixed and unchangeable. Recent studies suggest that the mechanisms mediating memory retrieval and the mechanisms that underlie the behavioral expression of memory can be dissociated, offering a new promise for the understanding of human memory persistence. Although reconsolidation studies typically use amnesic agents, it has also been shown that memory can be enhanced by pharmacological agents and real-life events during reconsolidation. Recently, we demonstrated that a mild stressor, cold pressor stress (CPS), can enhance human declarative memory during reconsolidation in a cued-recall test. Here we evaluate whether the recollection of 7- or 20-day-old long-term memories can be improved by exposure to two different neuromodulators: a mild stressor and glucose during reconsolidation. As expected, poor and very poor memory performance was found at the time of memory reactivation (days 6 and 20 after training). CPS during reconsolidation improved the long-term expression of a declarative memory 6 -but not 20-days after training. However, the administration of an oral source of glucose (juice), but not a diet juice, can enhance memory during reconsolidation even 20. days after training. Interestingly, when a recognition test was applied instead of a cued-recall test, memory performance was still robust at both 1 and 3. weeks after training. Here we show that the period in which this memory can be reactivated and become labile largely exceeds the period in which that memory is recalled, proving evidence that conscious access is not needed for reconsolidation. Present results are consistent with dissociation between the mechanisms mediating memory labilization and the mechanisms that underlie the behavioral expression of memory. © 2013 IBRO.

Registro:

Documento: Artículo
Título:The temporal dynamics of enhancing a human declarative memory during reconsolidation
Autor:Coccoz, V.; Sandoval, A.V.; Stehberg, J.; Delorenzi, A.
Filiación:Laboratorio de Neurobiología de la Memoria, Departamento de Fisiología y Biología Molecular y Celular, FCEyN, Universidad de Buenos Aires, IFIBYNE-CONICET, Argentina
Laboratorio de Neurobiología, Departamento de Ciencias Biológicas, Universidad Andres Bello, Chile
Centro de investigaciones Biomédicas, Universidad Andres Bello, Chile
Palabras clave:Forgetting; Memory enhancement; Memory expression; Memory modulation; Persistence; Reconsolidation; adult; analysis of variance; article; brain function; controlled study; declarative memory; diastolic blood pressure; dynamics; female; human; human experiment; long term memory; male; memory consolidation; mental performance; neuromodulation; normal human; priority journal; recall; reconsolidation; systolic blood pressure; verbal memory; visual memory; Adolescent; Adult; Cues; Female; Humans; Male; Memory, Long-Term; Photic Stimulation; Psychomotor Performance; Time Factors; Young Adult
Año:2013
Volumen:246
Página de inicio:397
Página de fin:408
DOI: http://dx.doi.org/10.1016/j.neuroscience.2013.04.033
Título revista:Neuroscience
Título revista abreviado:Neuroscience
ISSN:03064522
CODEN:NRSCD
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_03064522_v246_n_p397_Coccoz

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Citas:

---------- APA ----------
Coccoz, V., Sandoval, A.V., Stehberg, J. & Delorenzi, A. (2013) . The temporal dynamics of enhancing a human declarative memory during reconsolidation. Neuroscience, 246, 397-408.
http://dx.doi.org/10.1016/j.neuroscience.2013.04.033
---------- CHICAGO ----------
Coccoz, V., Sandoval, A.V., Stehberg, J., Delorenzi, A. "The temporal dynamics of enhancing a human declarative memory during reconsolidation" . Neuroscience 246 (2013) : 397-408.
http://dx.doi.org/10.1016/j.neuroscience.2013.04.033
---------- MLA ----------
Coccoz, V., Sandoval, A.V., Stehberg, J., Delorenzi, A. "The temporal dynamics of enhancing a human declarative memory during reconsolidation" . Neuroscience, vol. 246, 2013, pp. 397-408.
http://dx.doi.org/10.1016/j.neuroscience.2013.04.033
---------- VANCOUVER ----------
Coccoz, V., Sandoval, A.V., Stehberg, J., Delorenzi, A. The temporal dynamics of enhancing a human declarative memory during reconsolidation. Neuroscience. 2013;246:397-408.
http://dx.doi.org/10.1016/j.neuroscience.2013.04.033