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Abstract:

Finding objective and quantifiable imaging markers of mild traumatic brain injury (TBI) has proven challenging, especially in the military population. Changes in cortical thickness after injury have been reported in animals and in humans, but it is unclear how these alterations manifest in the chronic phase, and it is difficult to characterize accurately with imaging. We used cortical thickness measures derived from Advanced Normalization Tools (ANTs) to predict a continuous demographic variable: age. We trained four different regression models (linear regression, support vector regression, Gaussian process regression, and random forests) to predict age from healthy control brains from publicly available datasets (n = 762). We then used these models to predict brain age in military Service Members with TBI (n = 92) and military Service Members without TBI (n = 34). Our results show that all four models overpredicted age in Service Members with TBI, and the predicted age difference was significantly greater compared with military controls. These data extend previous civilian findings and show that cortical thickness measures may reveal an association of accelerated changes over time with military TBI. © Copyright 2017, Mary Ann Liebert, Inc.

Registro:

Documento: Artículo
Título:Accelerated Changes in Cortical Thickness Measurements with Age in Military Service Members with Traumatic Brain Injury
Autor:Savjani, R.R.; Taylor, B.A.; Acion, L.; Wilde, E.A.; Jorge, R.E.
Filiación:Michael E. DeBakey Veterans Affairs Medical Center, 2002 Holcombe Boulevard 153 TBI, Houston, TX 77030, United States
Department of Neuroscience, Baylor College of Medicine, Houston, TX, United States
Department of Radiology, Baylor College of Medicine, Houston, TX, United States
Department of Physical Medicine and Rehabilitation, Baylor College of Medicine, Houston, TX, United States
Department of Neurology, Baylor College of Medicine, Houston, TX, United States
Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX, United States
Texas A and M Health Science Center College of Medicine, Bryan, TX, United States
Instituto de Cálculo, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires - CONICET, Buenos Aires, Argentina
Palabras clave:ANTs; cortical thickness; gray matter; mild traumatic brain injury; MRI; mTBI; OEF/OIF/OND Service Members; TBI; traumatic brain injury; volumetrics; adult; age; Article; chronic disease; comorbidity; controlled study; cortical thickness (brain); disease association; disease severity; female; human; major clinical study; male; mental health; military service; neuroimaging; prediction; retrospective study; traumatic brain injury; age; brain concussion; brain cortex; diagnostic imaging; middle aged; nuclear magnetic resonance imaging; pathology; procedures; regression analysis; soldier; statistics and numerical data; theoretical model; traumatic brain injury; war; young adult; Adult; Afghan Campaign 2001-; Age Factors; Brain Concussion; Brain Injuries, Traumatic; Cerebral Cortex; Female; Humans; Iraq War, 2003-2011; Magnetic Resonance Imaging; Male; Middle Aged; Military Personnel; Models, Theoretical; Regression Analysis; Retrospective Studies; Young Adult
Año:2017
Volumen:34
Número:22
Página de inicio:3107
Página de fin:3116
DOI: http://dx.doi.org/10.1089/neu.2017.5022
Título revista:Journal of Neurotrauma
Título revista abreviado:J. Neurotrauma
ISSN:08977151
CODEN:JNEUE
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_08977151_v34_n22_p3107_Savjani

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Citas:

---------- APA ----------
Savjani, R.R., Taylor, B.A., Acion, L., Wilde, E.A. & Jorge, R.E. (2017) . Accelerated Changes in Cortical Thickness Measurements with Age in Military Service Members with Traumatic Brain Injury. Journal of Neurotrauma, 34(22), 3107-3116.
http://dx.doi.org/10.1089/neu.2017.5022
---------- CHICAGO ----------
Savjani, R.R., Taylor, B.A., Acion, L., Wilde, E.A., Jorge, R.E. "Accelerated Changes in Cortical Thickness Measurements with Age in Military Service Members with Traumatic Brain Injury" . Journal of Neurotrauma 34, no. 22 (2017) : 3107-3116.
http://dx.doi.org/10.1089/neu.2017.5022
---------- MLA ----------
Savjani, R.R., Taylor, B.A., Acion, L., Wilde, E.A., Jorge, R.E. "Accelerated Changes in Cortical Thickness Measurements with Age in Military Service Members with Traumatic Brain Injury" . Journal of Neurotrauma, vol. 34, no. 22, 2017, pp. 3107-3116.
http://dx.doi.org/10.1089/neu.2017.5022
---------- VANCOUVER ----------
Savjani, R.R., Taylor, B.A., Acion, L., Wilde, E.A., Jorge, R.E. Accelerated Changes in Cortical Thickness Measurements with Age in Military Service Members with Traumatic Brain Injury. J. Neurotrauma. 2017;34(22):3107-3116.
http://dx.doi.org/10.1089/neu.2017.5022