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Abstract:

Amplification of incoming sounds in the inner ear is modulated by an efferent pathway which travels back from the brain all the way to the cochlea. The medial olivocochlear system makes synaptic contacts with hair cells, where the neurotransmitter acetylcholine is released. Synaptic transmission is mediated by a unique nicotinic cholinergic receptor composed of α9 and α10 subunits, which is highly Ca 2+ permeable and is coupled to a Ca 2+-activated SK potassium channel. Thus, hyperpolarization of hair cells follows efferent fiber activation. In this work we review the literature that has enlightened our knowledge concerning the intimacies of this synapse. © 2011 Elsevier Ltd.

Registro:

Documento: Artículo
Título:The efferent medial olivocochlear-hair cell synapse
Autor:Elgoyhen, A.B.; Katz, E.
Filiación:Instituto de Investigaciones en Ingeniería Genética y Biología Molecular, Consejo Nacional de Investigaciones Científicas y Técnicas, Argentina
Tercera Cátedra de Farmacología, Facultad de Medicina, Universidad de Buenos Aires, 1428 Buenos Aires, Argentina
Departamento de Fisiología Biología Molecular y Celular, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, 1428 Buenos Aires, Argentina
Palabras clave:α9 and α10 Nicotinic receptors; Cochlea; Hair cells; Nicotinic receptors; Prestin; SK channels; Synaptic plasticity; acetylcholine; ion channel; nicotinic receptor; nicotinic receptor alpha10; nicotinic receptor alpha9; prestin; small conductance calcium activated potassium channel; unclassified drug; acetylcholine release; article; auditory stimulation; calcium cell level; cell activation; cell function; cell interaction; cell motility; cochlear nerve; efferent nerve; hair cell; human; hyperpolarization; intracellular signaling; membrane permeability; nerve cell inhibition; nerve cell plasticity; nonhuman; olivary nucleus; olivocochlear hair cell; potassium current; signal processing; sound transmission; synapse; synaptic transmission; vibration; Animals; Cochlea; Efferent Pathways; Hair Cells, Auditory; Humans; Olivary Nucleus; Receptors, Nicotinic; Synapses
Año:2012
Volumen:106
Número:1-2
Página de inicio:47
Página de fin:56
DOI: http://dx.doi.org/10.1016/j.jphysparis.2011.06.001
Título revista:Journal of Physiology Paris
Título revista abreviado:J. Physiol. Paris
ISSN:09284257
CODEN:JHYSE
CAS:acetylcholine, 51-84-3, 60-31-1, 66-23-9; Receptors, Nicotinic
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09284257_v106_n1-2_p47_Elgoyhen

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Citas:

---------- APA ----------
Elgoyhen, A.B. & Katz, E. (2012) . The efferent medial olivocochlear-hair cell synapse. Journal of Physiology Paris, 106(1-2), 47-56.
http://dx.doi.org/10.1016/j.jphysparis.2011.06.001
---------- CHICAGO ----------
Elgoyhen, A.B., Katz, E. "The efferent medial olivocochlear-hair cell synapse" . Journal of Physiology Paris 106, no. 1-2 (2012) : 47-56.
http://dx.doi.org/10.1016/j.jphysparis.2011.06.001
---------- MLA ----------
Elgoyhen, A.B., Katz, E. "The efferent medial olivocochlear-hair cell synapse" . Journal of Physiology Paris, vol. 106, no. 1-2, 2012, pp. 47-56.
http://dx.doi.org/10.1016/j.jphysparis.2011.06.001
---------- VANCOUVER ----------
Elgoyhen, A.B., Katz, E. The efferent medial olivocochlear-hair cell synapse. J. Physiol. Paris. 2012;106(1-2):47-56.
http://dx.doi.org/10.1016/j.jphysparis.2011.06.001