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Referencias:

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• Chen, H.Y., Fermin, A., Vardhana, S., Weng, I.C., Lo, K.F., Chang, E.Y., Maverakis, E., Dustin, M.L., Galectin-3 negatively regulates TCR-mediated CD4+ T-cell activation at the immunological synapse (2009) Proc Natl Acad Sci U S A, 106, pp. 14496-14501
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• Matarrese, P., Tinari, A., Mormone, E., Bianco, G.A., Toscano, M.A., Ascione, B., Rabinovich, G.A., Malorni, W., Galectin-1 sensitizes resting human T lymphocytes to Fas (CD95)-mediated cell death via mitochondrial hyperpolarization, budding, and fission (2005) J Biol Chem, 280, pp. 6969-6985
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• Yang, R.Y., Hsu, D.K., Liu, F.T., Expression of galectin-3 modulates T-cell growth and apoptosis (1996) Proc Natl Acad Sci U S A, 93, pp. 6737-6742
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• Blois, S.M., Ilarregui, J.M., Tometten, M., Garcia, M., Orsal, A.S., Cordo-Russo, R., Toscano, M.A., Handjiski, B., A pivotal role for galectin-1 in fetomaternal tolerance (2007) Nat Med, 13, pp. 1450-1457
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• Sampson, J.F., Suryawanshi, A., Chen, W.S., Rabinovich, G.A., Panjwani, N., Galectin-8 promotes regulatory T-cell differentiation by modulating IL-2 and TGFbeta signaling (2016) Immunol Cell Biol, 94, pp. 213-219
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• Markowska, A.I., Liu, F.T., Panjwani, N., Galectin-3 is an important mediator of VEGF- and bFGF-mediated angiogenic response (2010) J Exp Med, 207, pp. 1981-1993
• Machado, C.M., Andrade, L.N., Teixeira, V.R., Costa, F.F., Melo, C.M., dos Santos, S.N., Nonogaki, S., Camargo, A.A., Galectin-3 disruption impaired tumoral angiogenesis by reducing VEGF secretion from TGFbeta1-induced macrophages (2014) Cancer Med, 3, pp. 201-214
• Delgado, V.M., Nugnes, L.G., Colombo, L.L., Troncoso, M.F., Fernandez, M.M., Malchiodi, E.L., Frahm, I., Rabinovich, G.A., Modulation of endothelial cell migration and angiogenesis: a novel function for the tandem-repeat lectin galectin-8 (2011) FASEB J, 25, pp. 242-254
• Chen, W.S., Cao, Z., Sugaya, S., Lopez, M.J., Sendra, V.G., Laver, N., Leffler, H., Song, J., Pathological lymphangiogenesis is modulated by galectin-8-dependent crosstalk between podoplanin and integrin-associated VEGFR-3 (2016) Nat Commun, 7, p. 11302. , The authors report a galectin-8-driven pathway that controls lymphangiogenesis and links VEGF-C, podoplanin and α1β1 and α5β1 integrins
• Heusschen, R., Schulkens, I.A., van Beijnum, J., Griffioen, A.W., Thijssen, V.L., Endothelial LGALS9 splice variant expression in endothelial cell biology and angiogenesis (2014) Biochim Biophys Acta, 1842, pp. 284-292
• Lykken, J.M., Horikawa, M., Minard-Colin, V., Kamata, M., Miyagaki, T., Poe, J.C., Tedder, T.F., Galectin-1 drives lymphoma CD20 immunotherapy resistance: validation of a preclinical system to identify resistance mechanisms (2016) Blood, 127, pp. 1886-1895. , This study highlights the role of galectin-1 as a mechanism of resistance to anti-CD20 (rituximab) immunotherapy via regulation of antibody-mediated lymphoma phagocytosis
• Luo, W., Song, L., Chen, X.L., Zeng, X.F., Wu, J.Z., Zhu, C.R., Huang, T., Yang, Q., Identification of galectin-1 as a novel mediator for chemoresistance in chronic myeloid leukemia cells (2016) Oncotarget, 7, pp. 26709-26723
• Kuo, P., Bratman, S.V., Shultz, D.B., von Eyben, R., Chan, C., Wang, Z., Say, C., Giaccia, A.J., Galectin-1 mediates radiation-related lymphopenia and attenuates NSCLC radiation response (2014) Clin Cancer Res, 20, pp. 5558-5569
• Yamamoto-Sugitani, M., Kuroda, J., Ashihara, E., Nagoshi, H., Kobayashi, T., Matsumoto, Y., Sasaki, N., Nakayama, R., Galectin-3 (Gal-3) induced by leukemia microenvironment promotes drug resistance and bone marrow lodgment in chronic myelogenous leukemia (2011) Proc Natl Acad Sci U S A, 108, pp. 17468-17473
• Harazono, Y., Kho, D.H., Balan, V., Nakajima, K., Hogan, V., Raz, A., Extracellular galectin-3 programs multidrug resistance through Na+/K+-ATPase and P-glycoprotein signaling (2015) Oncotarget, 6, pp. 19592-19604
• Cagnoni, A.J., Perez Saez, J.M., Rabinovich, G.A., Marino, K.V., Turning-off signaling by siglecs selectins, and galectins: chemical inhibition of glycan-dependent interactions in cancer (2016) Front Oncol, 6, p. 109

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