Artículo

Locatelli, F.F.; Fernandez, P.C.; Villareal, F.; Muezzinoglu, K.; Huerta, R.; Galizia, C.G.; Smith, B.H. "Nonassociative plasticity alters competitive interactions among mixture components in early olfactory processing" (2013) European Journal of Neuroscience. 37(1):63-79
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Abstract:

Experience-related plasticity is an essential component of networks involved in early olfactory processing. However, the mechanisms and functions of plasticity in these neural networks are not well understood. We studied nonassociative plasticity by evaluating responses to two pure odors (A and X) and their binary mixture using calcium imaging of odor-elicited activity in output neurons of the honey bee antennal lobe. Unreinforced exposure to A or X produced no change in the neural response elicited by the pure odors. However, exposure to one odor (e.g. A) caused the response to the mixture to become more similar to that of the other component (X). We also show in behavioral analyses that unreinforced exposure to A caused the mixture to become perceptually more similar to X. These results suggest that nonassociative plasticity modifies neural networks in such a way that it affects local competitive interactions among mixture components. We used a computational model to evaluate the most likely targets for modification. Hebbian modification of synapses from inhibitory local interneurons to projection neurons most reliably produced the observed shift in response to the mixture. These results are consistent with a model in which the antennal lobe acts to filter olfactory information according to its relevance for performing a particular task. © 2012 Federation of European Neuroscience Societies and Blackwell Publishing Ltd.

Registro:

Documento: Artículo
Título:Nonassociative plasticity alters competitive interactions among mixture components in early olfactory processing
Autor:Locatelli, F.F.; Fernandez, P.C.; Villareal, F.; Muezzinoglu, K.; Huerta, R.; Galizia, C.G.; Smith, B.H.
Filiación:School of Life Sciences, Arizona State University, PO Box 874501, Tempe, AZ, 85287, United States
Biocircuits Institute, University of California, San Diego, La Jolla, CA, United States
Department of Biology, University of Konstanz, Konstanz, Germany
Lab. de Neurobiología de la Memoria, Dept. de Fisiologia, Biologia Molecular y Celular, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, IFIByNE, Ciudad Universitaria, Buenos Aires, 1428EHA, Argentina
INTA, EEA Delta del Paraná (UBA CONICET), Rio Paraná de las Palmas y Canal Comas, Campana, 2804, Argentina
Palabras clave:Antennal lobe; Learning; Olfaction; Plasticity; calcium; adaptation; animal cell; animal experiment; animal tissue; antenna (organ); Apis mellifera; article; association; behavioral science; controlled study; female; mathematical model; molecular imaging; molecular interaction; nerve cell inhibition; nerve cell membrane potential; nerve cell network; nerve cell plasticity; nerve projection; nonhuman; olfactory discrimination; olfactory tract; priority journal; sensory stimulation; stimulus response; synaptic inhibition; task performance; Animals; Arthropod Antennae; Bees; Calcium Signaling; Female; Ganglia, Invertebrate; Membrane Potentials; Models, Neurological; Neuronal Plasticity; Neurons; Odors; Olfactory Pathways; Olfactory Perception; Smell
Año:2013
Volumen:37
Número:1
Página de inicio:63
Página de fin:79
DOI: http://dx.doi.org/10.1111/ejn.12021
Título revista:European Journal of Neuroscience
Título revista abreviado:Eur. J. Neurosci.
ISSN:0953816X
CODEN:EJONE
CAS:calcium, 14092-94-5, 7440-70-2
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0953816X_v37_n1_p63_Locatelli

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Citas:

---------- APA ----------
Locatelli, F.F., Fernandez, P.C., Villareal, F., Muezzinoglu, K., Huerta, R., Galizia, C.G. & Smith, B.H. (2013) . Nonassociative plasticity alters competitive interactions among mixture components in early olfactory processing. European Journal of Neuroscience, 37(1), 63-79.
http://dx.doi.org/10.1111/ejn.12021
---------- CHICAGO ----------
Locatelli, F.F., Fernandez, P.C., Villareal, F., Muezzinoglu, K., Huerta, R., Galizia, C.G., et al. "Nonassociative plasticity alters competitive interactions among mixture components in early olfactory processing" . European Journal of Neuroscience 37, no. 1 (2013) : 63-79.
http://dx.doi.org/10.1111/ejn.12021
---------- MLA ----------
Locatelli, F.F., Fernandez, P.C., Villareal, F., Muezzinoglu, K., Huerta, R., Galizia, C.G., et al. "Nonassociative plasticity alters competitive interactions among mixture components in early olfactory processing" . European Journal of Neuroscience, vol. 37, no. 1, 2013, pp. 63-79.
http://dx.doi.org/10.1111/ejn.12021
---------- VANCOUVER ----------
Locatelli, F.F., Fernandez, P.C., Villareal, F., Muezzinoglu, K., Huerta, R., Galizia, C.G., et al. Nonassociative plasticity alters competitive interactions among mixture components in early olfactory processing. Eur. J. Neurosci. 2013;37(1):63-79.
http://dx.doi.org/10.1111/ejn.12021