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Abstract:

Experiments were undertaken to determine the distribution and binding profile of dopamine (DA) receptors within a key extra-striatal region of the rat basal ganglia, the subthalamic nucleus (STh). Analysis of [l25I]NCQ-298 autoradiograms showed that binding sites of the D2-receptor family are abundant in the STh. Competition studies indicated that these sites were specifically of the D2 sub-type. However, contrary to previously published data, [l25I]SCH-23982 autoradiograms failed to reveal D1 receptor binding in the STh. These data suggest that DA acting at D2 receptors may directly modulate STh neural activity and furthermore that the antagonism of STh D2 receptor binding by neuroleptics may be involved in the expression of extrapyramidal motor disturbances. © Rapid Communications of Oxford Ltd.

Registro:

Documento: Artículo
Título:Characterization of dopamine receptor binding sites in the subthalamic nucleus
Autor:Johnson, A.E.; Coirini, H.; Källström, L.; Wiesel, F.-A.
Filiación:Psychiatry Department, University Hospital, Uppsala University, Uppsala, 75017, Sweden
Instituto de Biologia y Medicina Experimental, Buenos Aires, 1428, Argentina
Palabras clave:Basal ganglia; D1 receptors; D2 receptors; Dopamine; Entopeduncular nucleus; Extrapyramidal motor system; Neuroleptics; Subthalamic nucleus; [125I]SCH-23982; [l25I]NCQ-298; 2 dipropylamino 7 hydroxytetralin; 2,3,4,5 tetrahydro 8 iodo 3 methyl 5 phenyl 1h 3 benzazepin 7 ol; 8 chloro 2,3,4,5 tetrahydro 3 methyl 5 phenyl 1h 3 benzazepin 7 ol hydrogen maleate; clozapine; dopamine; dopamine 1 receptor; dopamine 2 receptor; eticlopride; fluphenazine; n [(1 ethyl 2 pyrrolidinyl)methyl] 3 iodo 5,6 dimethoxysalicylamide; neuroleptic agent; raclopride; animal tissue; article; autoradiography; controlled study; female; nonhuman; priority journal; rat; receptor binding; subthalamic nucleus; Animal; Autoradiography; Dopamine Agonists; Dopamine Antagonists; Female; Iodine Radioisotopes; Ligands; Rats; Rats, Sprague-Dawley; Receptors, Dopamine; Receptors, Dopamine D1; Receptors, Dopamine D2; Salicylamides; Sch-23390; Support, Non-U.S. Gov't; Thalamic Nuclei
Año:1994
Volumen:5
Número:14
Página de inicio:1836
Página de fin:1838
DOI: http://dx.doi.org/10.1097/00001756-199409080-00038
Título revista:NeuroReport
Título revista abreviado:NeuroReport
ISSN:09594965
CAS:2 dipropylamino 7 hydroxytetralin, 74938-11-7; 2,3,4,5 tetrahydro 8 iodo 3 methyl 5 phenyl 1h 3 benzazepin 7 ol, 116780-39-3; 8 chloro 2,3,4,5 tetrahydro 3 methyl 5 phenyl 1h 3 benzazepin 7 ol hydrogen maleate, 87134-87-0; clozapine, 5786-21-0; dopamine, 51-61-6, 62-31-7; eticlopride, 84226-12-0, 97612-24-3; fluphenazine, 146-56-5, 69-23-8; n [(1 ethyl 2 pyrrolidinyl)methyl] 3 iodo 5,6 dimethoxysalicylamide, 131062-31-2; raclopride, 84225-95-6; Dopamine Agonists; Dopamine Antagonists; Iodine Radioisotopes; Ligands; NCQ 298, 131062-31-2; Receptors, Dopamine D1; Receptors, Dopamine D2; Receptors, Dopamine; Salicylamides; Sch 23982, 116780-39-3; Sch-23390, 87075-17-0
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09594965_v5_n14_p1836_Johnson

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Citas:

---------- APA ----------
Johnson, A.E., Coirini, H., Källström, L. & Wiesel, F.-A. (1994) . Characterization of dopamine receptor binding sites in the subthalamic nucleus. NeuroReport, 5(14), 1836-1838.
http://dx.doi.org/10.1097/00001756-199409080-00038
---------- CHICAGO ----------
Johnson, A.E., Coirini, H., Källström, L., Wiesel, F.-A. "Characterization of dopamine receptor binding sites in the subthalamic nucleus" . NeuroReport 5, no. 14 (1994) : 1836-1838.
http://dx.doi.org/10.1097/00001756-199409080-00038
---------- MLA ----------
Johnson, A.E., Coirini, H., Källström, L., Wiesel, F.-A. "Characterization of dopamine receptor binding sites in the subthalamic nucleus" . NeuroReport, vol. 5, no. 14, 1994, pp. 1836-1838.
http://dx.doi.org/10.1097/00001756-199409080-00038
---------- VANCOUVER ----------
Johnson, A.E., Coirini, H., Källström, L., Wiesel, F.-A. Characterization of dopamine receptor binding sites in the subthalamic nucleus. NeuroReport. 1994;5(14):1836-1838.
http://dx.doi.org/10.1097/00001756-199409080-00038