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Abstract:

Oxidants play a role in several stages of carcinogenesis. A high antioxidant capacity is expected to protect 'initiated' cells from excessive oxidant toxicity. The aim of this study was to determine the chemopreventive effect of α-tocopherol (α-T) on the hepatocarcinogenesis induced with p- dimethylaminoazobenzene (DAB) in mice. The dietary administration of α-T completely reversed the induction of δ-aminolevulinate synthetase and glutathione-S-transferase (the tumoral marker enzyme). α-T greatly enhanced P 450 levels, which were even higher in animals exposed to DAB. Indirect evidence for the involvement of oxygen radicals in the DAB model of hepatocarcinogenesis was provided by increased levels of thiobarbituric acid reactive species, which were detected in animals with severe liver damage and were assessed by histological analysis. α-T reduced the degree of hepatic injury, although this vitamin produced only slight changes in the oxidative parameters evaluated. The use of α-T as a potential chemopreventive agent, particularly during the initiation stage of carcinogenesis provoked by DAB, is worthy of further study.

Registro:

Documento: Artículo
Título:Hepatic enzymatic metabolism alterations and oxidative stress during the onset of carcinogenesis: Protective role of α-tocopherol
Autor:Gerez, E.; Caballero, F.; Vazquez, E.; Polo, C.; Del C. Batlle, A.M.
Filiación:Ctro. Invest. Sobre Porfirinas P., Ciudad Universitaria, Pabellón II, 1428 Buenos Aires, Argentina
Viamonte 1881 10o A, 1056 - Buenos Aires, Argentina
Palabras clave:α-Tocopherol; Drug metabolizing enzyme system; Heme metabolism; Hepatocarcinogenesis; Oxidative stress; p-dimethylaminoazobenzene; 4 dimethylaminoazobenzene; 5 aminolevulinate synthase; alpha tocopherol; antioxidant; cytochrome p450; glutathione transferase; heme; animal experiment; animal model; animal tissue; antioxidant activity; article; controlled study; liver cancer; liver carcinogenesis; liver metabolism; male; mouse; nonhuman; oxidative stress; priority journal; vitamin metabolism; xenobiotic metabolism; 5-Aminolevulinate Synthetase; Animals; Antioxidants; Carcinogens; Enzyme Induction; Glutathione Transferase; Liver Neoplasms, Experimental; Male; Mice; Oxidative Stress; p-Dimethylaminoazobenzene; Vitamin E
Año:1998
Volumen:7
Número:1
Página de inicio:69
Página de fin:76
Título revista:European Journal of Cancer Prevention
Título revista abreviado:Eur.J. Cancer Prev.
ISSN:09598278
CODEN:EJUPE
CAS:5-Aminolevulinate Synthetase, EC 2.3.1.37; Antioxidants; Carcinogens; Glutathione Transferase, EC 2.5.1.18; p-Dimethylaminoazobenzene, 60-11-7; Vitamin E, 1406-18-4
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09598278_v7_n1_p69_Gerez

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Citas:

---------- APA ----------
Gerez, E., Caballero, F., Vazquez, E., Polo, C. & Del C. Batlle, A.M. (1998) . Hepatic enzymatic metabolism alterations and oxidative stress during the onset of carcinogenesis: Protective role of α-tocopherol. European Journal of Cancer Prevention, 7(1), 69-76.
Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09598278_v7_n1_p69_Gerez [ ]
---------- CHICAGO ----------
Gerez, E., Caballero, F., Vazquez, E., Polo, C., Del C. Batlle, A.M. "Hepatic enzymatic metabolism alterations and oxidative stress during the onset of carcinogenesis: Protective role of α-tocopherol" . European Journal of Cancer Prevention 7, no. 1 (1998) : 69-76.
Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09598278_v7_n1_p69_Gerez [ ]
---------- MLA ----------
Gerez, E., Caballero, F., Vazquez, E., Polo, C., Del C. Batlle, A.M. "Hepatic enzymatic metabolism alterations and oxidative stress during the onset of carcinogenesis: Protective role of α-tocopherol" . European Journal of Cancer Prevention, vol. 7, no. 1, 1998, pp. 69-76.
Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09598278_v7_n1_p69_Gerez [ ]
---------- VANCOUVER ----------
Gerez, E., Caballero, F., Vazquez, E., Polo, C., Del C. Batlle, A.M. Hepatic enzymatic metabolism alterations and oxidative stress during the onset of carcinogenesis: Protective role of α-tocopherol. Eur.J. Cancer Prev. 1998;7(1):69-76.
Available from: https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09598278_v7_n1_p69_Gerez [ ]