Artículo

La versión final de este artículo es de uso interno de la institución.
Consulte el artículo en la página del editor
Consulte la política de Acceso Abierto del editor

Abstract:

Identifying the sequence of computations which constitute a cognitive task is a fundamental problem in neuroscience. Here we show, using functional magnetic resonance imaging (fMRI), that we can parse, at the time scale of about 100 ms, the different stages of brain activations which compose a complex sequential task. To identify timing information from the slow blood oxygen level-dependent (BOLD) signal response, we use a simple analytic method, based on periodic stimulation and an analysis of covariation of the spectral parameters (phase and power spectrum at the stimulation frequency) with the different experimental conditions. We implement this strategy in a sequential task, where the onset and duration of different stages are under experimental control. We are able to detect changes in onset latency and in the duration of the response, in an invariant fashion across different brain regions, and reconstruct the stream of activations consistent with five distinct stages of processing of the task. Sensory and motor clusters activate in the expected order and for the expected duration. The timing of sensory activations is more precise than the timing of motor activation. We also parse in time the reading-verbal network: visual extrastriate and phonological access regions (supramarginal gyrus) activate at the time of word presentation, while the inferior frontal gyrus, the anterior cingulate and the supplementary motor area are activated during the rehearsal period. © 2006 Elsevier Inc. All rights reserved.

Registro:

Documento: Artículo
Título:Parsing a sequence of brain activations at psychological times using fMRI
Autor:Sigman, M.; Jobert, A.; LeBihan, D.; Dehaene, S.
Filiación:Integrative Neuroscience Laboratory Physics Department, FCEyN, UBA, Buenos Aires, Argentina
INSERM-CEA unit 562 Cognitive Neuroimaging, Service Hospitalier Frédéric Joliot, Orsay, France
Palabras clave:Additive factors; Cognitive; fMRI; Language; Sequences; Timing; oxygen; adult; analytic method; article; brain function; brain region; cingulate gyrus; covariance; frontal gyrus; functional magnetic resonance imaging; human; information; latent period; motor activity; motor system; normal human; oxygen blood level; phonetics; power spectrum; priority journal; reading; sensory stimulation; sensory system; sequential analysis; spectroscopy; speech articulation; stimulation; supramarginal gyrus; verbal behavior; Adult; Brain; Cognition; Humans; Magnetic Resonance Imaging; Task Performance and Analysis; Time Factors
Año:2007
Volumen:35
Número:2
Página de inicio:655
Página de fin:668
DOI: http://dx.doi.org/10.1016/j.neuroimage.2006.05.064
Título revista:NeuroImage
Título revista abreviado:NeuroImage
ISSN:10538119
CODEN:NEIME
CAS:oxygen, 7782-44-7
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_10538119_v35_n2_p655_Sigman

Referencias:

  • Aguirre, G.K., Zarahn, E., D'Esposito, M., The variability of human, BOLD hemodynamic responses (1998) NeuroImage, 8, pp. 360-369
  • Andersen, R.A., Encoding of intention and spatial location in the posterior parietal cortex (1995) Cereb. Cortex, 5, pp. 457-469
  • Bellgowan, P.S., Saad, Z.S., Bandettini, P.A., Understanding neural system dynamics through task modulation and measurement of functional MRI amplitude, latency, and width (2003) Proc. Natl. Acad. Sci. U. S. A., 100, pp. 1415-1419
  • Binder, J.R., Frost, J.A., Hammeke, T.A., Bellgowan, P.S., Springer, J.A., Kaufman, J.N., Possing, E.T., Human temporal lobe activation by speech and nonspeech sounds (2000) Cereb. Cortex, 10, pp. 512-528
  • Boynton, G.M., Engel, S.A., Glover, G.H., Heeger, D.J., Linear systems analysis of functional magnetic resonance imaging in human V1 (1996) J. Neurosci., 16, pp. 4207-4221
  • Buckner, R.L., The hemodynamic inverse problem: making inferences about neural activity from measured MRI signals (2003) Proc. Natl. Acad. Sci. U. S. A., 100, pp. 2177-2179
  • Buckner, R.L., Bandettini, P.A., O'Craven, K.M., Savoy, R.L., Petersen, S.E., Raichle, M.E., Rosen, B.R., Detection of cortical activation during averaged single trials of a cognitive task using functional magnetic resonance imaging (1996) Proc. Natl. Acad. Sci. U. S. A., 93, pp. 14878-14883
  • Cohen, L., Dehaene, S., Specialization within the ventral stream: the case for the visual word form area (2004) NeuroImage, 22, pp. 466-476
  • Colby, C.L., Duhamel, J.R., Goldberg, M.E., Visual, presaccadic, and cognitive activation of single neurons in monkey lateral intraparietal area (1996) J. Neurophysiol., 76, pp. 2841-2852
  • Dale, A.M., Buckner, R.L., Selective averaging of rapidly presented trials using fMRI (1997) Hum. Brain Mapp., 5, pp. 329-340
  • Dale, A.M., Liu, A.K., Fischl, B.R., Buckner, R.L., Belliveau, J.W., Lewine, J.D., Halgren, E., Dynamic statistical parametric mapping: combining fMRI and MEG for high-resolution imaging of cortical activity (2000) Neuron, 26, pp. 55-67
  • Dehaene, S., Spelke, E., Pinel, P., Stanescu, R., Tsivkin, S., Sources of mathematical thinking: behavioral and brain-imaging evidence (1999) Science, 284, pp. 970-974
  • Doyon, J., Owen, A.M., Petrides, M., Sziklas, V., Evans, A.C., Functional anatomy of visuomotor skill learning in human subjects examined with positron emission tomography (1996) Eur. J. Neurosci., 8, pp. 637-648
  • Eger, E., Sterzer, P., Russ, M.O., Giraud, A.L., Kleinschmidt, A., A supramodal number representation in human intraparietal cortex (2003) Neuron, 37, pp. 719-725
  • Formisano, E., Goebel, R., Tracking cognitive processes with functional MRI mental chronometry (2003) Curr. Opin. Neurobiol., 13, pp. 174-181
  • Formisano, E., Linden, D.E., Di Salle, F., Trojano, L., Esposito, F., Sack, A.T., Grossi, D., Goebel, R., Tracking the mind's image in the brain: I. Time-resolved fMRI during visuospatial mental imagery (2002) Neuron, 35, pp. 185-194
  • Fries, W., Swihart, A.A., Disturbance of rhythm sense following right hemisphere damage (1990) Neuropsychologia, 28, pp. 1317-1323
  • Frot, M., Mauguiere, F., Timing and spatial distribution of somatosensory responses recorded in the upper bank of the sylvian fissure (SII area) in humans (1999) Cereb. Cortex, 9, pp. 854-863
  • Graybiel, A.M., Kimura, M., Adaptative neural networks in the basal ganglia (1995) Models of Information Processing in the Basal Ganglia, pp. 103-116. , Houk J.C., Davis J.L., and Beiser D.G. (Eds), MIT Press, Cambridge
  • Gusnard, D.A., Raichle, M.E., Searching for a baseline: functional imaging and the resting human brain (2001) Nat. Rev., Neurosci., 2, pp. 685-694
  • Henson, R., Shallice, T., Dolan, R., Neuroimaging evidence for dissociable forms of repetition priming (2000) Science, 287, pp. 1269-1272
  • Henson, R.N., Price, C.J., Rugg, M.D., Turner, R., Friston, K.J., Detecting latency differences in event-related BOLD responses: application to words versus nonwords and initial versus repeated face presentations (2002) NeuroImage, 15, pp. 83-97
  • Jiang, Y., Saxe, R., Kanwisher, N., Functional magnetic resonance imaging provides new constraints on Theories of the Psychological Refractory Period (2004) Psychol. Sci., 15 (6), pp. 390-396
  • Kim, S.G., Richter, W., Ugurbil, K., Limitations of temporal resolution in functional MRI (1997) Magn. Reson. Med., 37, pp. 631-636
  • Koechlin, E., Danek, A., Burnod, Y., Grafman, J., Medial prefrontal and subcortical mechanisms underlying the acquisition of motor and cognitive action sequences in humans (2002) Neuron, 35, pp. 371-381
  • Kruggel, F., von Cramon, D.Y., Temporal properties of the hemodynamic response in functional MRI (1999) Hum. Brain Mapp., 8, pp. 259-271
  • Kruggel, F., Zysset, S., von Cramon, D.Y., Nonlinear regression of functional MRI data: an item recognition task study (2000) NeuroImage, 12, pp. 173-183
  • Lange, N., Zeger, S.L., Non-linear Fourier time series analysis for human brain mapping by functional magnetic resonance imaging (with Discussion) (1997) Appl. Stat., 46, pp. 1-29
  • Lee, A.T., Glover, G.H., Meyer, C.H., Discrimination of large venous vessels in time-course spiral blood-oxygen-level-dependent magnetic-resonance functional neuroimaging (1995) Magn. Reson. Med., 33, pp. 745-754
  • Lee, S.H., Blake, R., Heeger, D.J., Traveling waves of activity in primary visual cortex during binocular rivalry (2005) Nat. Neurosci., 8, pp. 22-23
  • Liao, C.H., Worsley, K.J., Poline, J.B., Aston, J.A., Duncan, G.H., Evans, A.C., Estimating the delay of the fMRI response (2002) NeuroImage, 16, pp. 593-606
  • Mazurek, M.E., Roitman, J.D., Ditterich, J., Shadlen, M.N., A role for neural integrators in perceptual decision making (2003) Cereb. Cortex, 13, pp. 1257-1269
  • Menon, R.S., Kim, S.G., Spatial and temporal limits in cognitive neuroimaging with fMRI (1999) Trends Cogn. Sci., 3, pp. 207-216
  • Menon, R.S., Luknowsky, D.C., Gati, J.S., Mental chronometry using latency-resolved functional MRI (1998) Proc. Natl. Acad. Sci. U. S. A., 95, pp. 10902-10907
  • Miezin, F.M., Maccotta, L., Ollinger, J.M., Petersen, S.E., Buckner, R.L., Characterizing the hemodynamic response: effects of presentation rate, sampling procedure, and the possibility of ordering brain activity based on relative timing (2000) NeuroImage, 11, pp. 735-759
  • Pashler, H., Processing stages in overlapping tasks: evidence for a central bottleneck (1984) J. Exp. Psychol. Hum. Percept. Perform, 10, pp. 358-377
  • Posner, M.I., (1978) Chronmetric Explorations of Mind, , Erlbaum, Hilsdale, NJ
  • Purdon, P.L., Solo, V., Weisskoff, R.M., Brown, E.N., Locally regularized spatiotemporal modeling and model comparison for functional MRI (2001) NeuroImage, 14, pp. 912-923
  • Rajapakse, J.C., Kruggel, F., Maisog, J.M., von Cramon, D.Y., Modeling hemodynamic response for analysis of functional MRI time-series (1998) Hum. Brain Mapp., 6, pp. 283-300
  • Richter, W., Andersen, P.M., Georgopoulos, A.P., Kim, S.G., Sequential activity in human motor areas during a delayed cued finger movement task studied by time-resolved fMRI (1997) NeuroReport, 8, pp. 1257-1261
  • Richter, W., Ugurbil, K., Georgopoulos, A., Kim, S.G., Time-resolved fMRI of mental rotation (1997) NeuroReport, 8, pp. 3697-3702
  • Richter, W., Somorjai, R., Summers, R., Jarmasz, M., Menon, R.S., Gati, J.S., Georgopoulos, A.P., Kim, S.G., Motor area activity during mental rotation studied by time-resolved single-trial fMRI (2000) J. Cogn. Neurosci., 12, pp. 310-320
  • Riecker, A., Wildgruber, D., Dogil, G., Grodd, W., Ackermann, H., Hemispheric lateralization effects of rhythm implementation during syllable repetitions: an fMRI study (2002) NeuroImage, 16, pp. 169-176
  • Robbins, T.W., Everitt, B.J., Neurobehavioural mechanisms of reward and motivation (1996) Curr. Opin. Neurobiol., 6, pp. 228-236
  • Roitman, J.D., Shadlen, M.N., Response of neurons in the lateral intraparietal area during a combined visual discrimination reaction time task (2002) J. Neurosci., 22, pp. 9475-9489
  • Rosen, B.R., Buckner, R.L., Dale, A.M., Event-related functional MRI: past, present, and future (1998) Proc. Natl. Acad. Sci. U. S. A., 95, pp. 773-780
  • Saad, Z.S., Ropella, K.M., Cox, R.W., DeYoe, E.A., Analysis and use of FMRI response delays (2001) Hum. Brain Mapp., 13, pp. 74-93
  • Saad, Z.S., DeYoe, E.A., Ropella, K.M., Estimation of FMRI response delays (2003) NeuroImage, 18, pp. 494-504
  • Schacter, D.L., Buckner, R.L., Koutstaal, W., Dale, A.M., Rosen, B.R., Late onset of anterior prefrontal activity during true and false recognition: an event-related fMRI study (1997) NeuroImage, 6, pp. 259-269
  • Schultz, W., Apicella, P., Romo, R., Scarnati, E., Context-dependent activity in primate striatum reflecting past and future behavioral events (1995) Models of Information Processing in the Basal Ganglia, pp. 11-26. , Houk J.C., Davis J.L., and Beiser D.G. (Eds), MIT Press, Cambridge
  • Scott, S.K., Johnsrude, I.S., The neuroanatomical and functional organization of speech perception (2003) Trends Neurosci., 26, pp. 100-107
  • Sigman, M., Dehaene, S., Parsing a cognitive task: a characterization of the mind's bottleneck (2005) PLoS Biol., 3, pp. e37
  • Sigman, M., Dehaene, S., Dynamics of the central bottleneck: dual-task and task uncertainty (2006) PLoS Biol., 4, pp. e220
  • Sternberg, S., The discovery of processing stages: extension of Donders' method (1969) Attention and Performance II, pp. 276-315. , Koster W.G. (Ed), North-Holland Publishing, Amsterdam
  • Sternberg, S., Separate modifiability and the search for processing modules (2004) Attention and Performance XX, , Kanwisher N., and Duncan J. (Eds), Oxford Univ. Press, Oxford
  • Thierry, G., Boulanouar, K., Kherif, F., Ranjeva, J.P., Demonet, J.F., Temporal sorting of neural components underlying phonological processing (1999) NeuroReport, 10, pp. 2599-2603
  • Weilke, F., Spiegel, S., Boecker, H., von Einsiedel, H.G., Conrad, B., Schwaiger, M., Erhard, P., Time-resolved fMRI of activation patterns in M1 and SMA during complex voluntary movement (2001) J. Neurophysiol., 85, pp. 1858-1863
  • Wildgruber, D., Kischka, U., Ackermann, H., Klose, U., Grodd, W., Dynamic pattern of brain activation during sequencing of word strings evaluated by fMRI (1999) Brain Res. Cogn. Brain Res., 7, pp. 285-294

Citas:

---------- APA ----------
Sigman, M., Jobert, A., LeBihan, D. & Dehaene, S. (2007) . Parsing a sequence of brain activations at psychological times using fMRI. NeuroImage, 35(2), 655-668.
http://dx.doi.org/10.1016/j.neuroimage.2006.05.064
---------- CHICAGO ----------
Sigman, M., Jobert, A., LeBihan, D., Dehaene, S. "Parsing a sequence of brain activations at psychological times using fMRI" . NeuroImage 35, no. 2 (2007) : 655-668.
http://dx.doi.org/10.1016/j.neuroimage.2006.05.064
---------- MLA ----------
Sigman, M., Jobert, A., LeBihan, D., Dehaene, S. "Parsing a sequence of brain activations at psychological times using fMRI" . NeuroImage, vol. 35, no. 2, 2007, pp. 655-668.
http://dx.doi.org/10.1016/j.neuroimage.2006.05.064
---------- VANCOUVER ----------
Sigman, M., Jobert, A., LeBihan, D., Dehaene, S. Parsing a sequence of brain activations at psychological times using fMRI. NeuroImage. 2007;35(2):655-668.
http://dx.doi.org/10.1016/j.neuroimage.2006.05.064