Artículo

Blois, S.M.; Ilarregui, J.M.; Tometten, M.; Garcia, M.; Orsal, A.S.; Cordo-Russo, R.; Toscano, M.A.; Bianco, G.A.; Kobelt, P.; Handjiski, B.; Tirado, I.; Markert, U.R.; Klapp, B.F.; Poirier, F.; Szekeres-Bartho, J.; Rabinovich, G.A.; Arck, P.C. "A pivotal role for galectin-1 in fetomaternal tolerance" (2007) Nature Medicine. 13(12):1450-1457
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Abstract:

A successful pregnancy requires synchronized adaptation of maternal immune-endocrine mechanisms to the fetus. Here we show that galectin-1 (Gal-1), an immunoregulatory glycan-binding protein, has a pivotal role in conferring fetomaternal tolerance. Consistently with a marked decrease in Gal-1 expression during failing pregnancies, Gal-1-deficient (Lgals1-/-) mice showed higher rates of fetal loss compared to wild-type mice in allogeneic matings, whereas fetal survival was unaffected in syngeneic matings. Treatment with recombinant Gal-1 prevented fetal loss and restored tolerance through multiple mechanisms, including the induction of tolerogenic dendritic cells, which in turn promoted the expansion of interleukin-10 (IL-10)-secreting regulatory T cells in vivo. Accordingly, Gal-1's protective effects were abrogated in mice depleted of regulatory T cells or deficient in IL-10. In addition, we provide evidence for synergy between Gal-1 and progesterone in the maintenance of pregnancy. Thus, Gal-1 is a pivotal regulator of fetomaternal tolerance that has potential therapeutic implications in threatened pregnancies. © 2007 Nature Publishing Group.

Registro:

Documento: Artículo
Título:A pivotal role for galectin-1 in fetomaternal tolerance
Autor:Blois, S.M.; Ilarregui, J.M.; Tometten, M.; Garcia, M.; Orsal, A.S.; Cordo-Russo, R.; Toscano, M.A.; Bianco, G.A.; Kobelt, P.; Handjiski, B.; Tirado, I.; Markert, U.R.; Klapp, B.F.; Poirier, F.; Szekeres-Bartho, J.; Rabinovich, G.A.; Arck, P.C.
Filiación:University Medicine Berlin, Biomedical Research Building, Campus Virchow, Augustenburger Platz 1, Berlin 13353, Germany
Laboratorio de Inmunopatología, Instituto de Biología Y Medicina Experimental (IBYME), Consejo Nacional de Investigaciones Cientificas Y Tecnicas (CONICET), Vuelta de Obligado 2490, Buenos Aires C1428, Argentina
Department of Medicine, Division of Hepatology, Gastroenterology, and Endocrinology, University Medicine Berlin, Berlin 13353, Germany
Departamento de Bioquímica Y Biología Molecular, Facultad de Medicina, Universidad de Granada, Granada 18012, Spain
Placenta-Labor, Department of Obstetrics, Friedrich-Schiller-University Jena, 07740 Jena, Germany
Departement de Biologie du Developpement, Institut Jacques Monod, Univ. Paris 6 and Paris 7, Paris 75251 Paris, France
Department of Medical Microbiology and Immunology, Hungarian Academy of Sciences, Pecs University Medical School, Pecs 7643, Hungary
Departmento de Química Biológica, Facultad de Ciencias Exactas Y Naturales, Universidad de Buenos Aires, Buenos Aires C1428, Argentina
Palabras clave:galectin 1; animal cell; animal experiment; article; controlled study; cytokine release; dendritic cell; fetoplacental unit; fetus wastage; immunoregulation; in vivo culture; mouse; nonhuman; pregnancy disorder; priority journal; protein binding; protein expression; regulatory T lymphocyte; Animals; CD4-Positive T-Lymphocytes; Female; Galectin 1; Gene Expression Regulation, Developmental; Histocompatibility, Maternal-Fetal; Immune Tolerance; Interleukin-2 Receptor alpha Subunit; Mice; Mice, Transgenic; Polysaccharides; Pregnancy; Pregnancy, Animal; T-Lymphocytes, Regulatory; Transplantation, Homologous; Mus
Año:2007
Volumen:13
Número:12
Página de inicio:1450
Página de fin:1457
DOI: http://dx.doi.org/10.1038/nm1680
Título revista:Nature Medicine
Título revista abreviado:Nat. Med.
ISSN:10788956
CODEN:NAMEF
CAS:galectin 1, 258495-34-0; Galectin 1; Interleukin-2 Receptor alpha Subunit; Polysaccharides
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_10788956_v13_n12_p1450_Blois

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Citas:

---------- APA ----------
Blois, S.M., Ilarregui, J.M., Tometten, M., Garcia, M., Orsal, A.S., Cordo-Russo, R., Toscano, M.A.,..., Arck, P.C. (2007) . A pivotal role for galectin-1 in fetomaternal tolerance. Nature Medicine, 13(12), 1450-1457.
http://dx.doi.org/10.1038/nm1680
---------- CHICAGO ----------
Blois, S.M., Ilarregui, J.M., Tometten, M., Garcia, M., Orsal, A.S., Cordo-Russo, R., et al. "A pivotal role for galectin-1 in fetomaternal tolerance" . Nature Medicine 13, no. 12 (2007) : 1450-1457.
http://dx.doi.org/10.1038/nm1680
---------- MLA ----------
Blois, S.M., Ilarregui, J.M., Tometten, M., Garcia, M., Orsal, A.S., Cordo-Russo, R., et al. "A pivotal role for galectin-1 in fetomaternal tolerance" . Nature Medicine, vol. 13, no. 12, 2007, pp. 1450-1457.
http://dx.doi.org/10.1038/nm1680
---------- VANCOUVER ----------
Blois, S.M., Ilarregui, J.M., Tometten, M., Garcia, M., Orsal, A.S., Cordo-Russo, R., et al. A pivotal role for galectin-1 in fetomaternal tolerance. Nat. Med. 2007;13(12):1450-1457.
http://dx.doi.org/10.1038/nm1680