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Abstract:

Nasal cavity tumors are usually diagnosed late, when they already have infiltrated adjacent tissues thus requiring very aggressive treatments with serious side effects. Here we use electrochemotherapy (ECT), a well demonstrated treatment modality for superficial tumors. In the case of deep-seated tumors, the main limitation of ECT is reaching the tumor with an appropriate electric field. To overcome this limitation we introduce the single needle electrode (SiNE), a minimally invasive device that can deliver an appropriate electric field with a simple procedure. Twenty-one canine patients with spontaneous tumors were selected, eleven were treated using the SiNE with ECT, and ten with surgery plus adjuvant chemotherapy as a control group. In the SiNE group, 27% achieved a complete response, 64% had a partial response, and 9% had a stable disease. This means that 91% of objective responses were obtained. The mean overall survival was 16.86 months (4-32 months, median 16.5 months), with a survival rate significantly higher (p = 0.0008) when compared with control group. The only side effect observed was the inflammation of the treated nasal passage, which was controlled with corticosteroid therapy for one week. One year after the treatment, 60% of the canine of the SiNE group vs. 10% of the control group remained alive, and after the 32 months follow-up, the survival rate were 30% and 0%, respectively. ECT with the SiNE can be safely used in canine to treat nasal tumors with encouraging results. © 2017 2017 Felipe Maglietti, Matías Tellado, Nahuel Olaiz, Sebastian Michinski, Guillermo Marshall.

Registro:

Documento: Artículo
Título:Minimally invasive electrochemotherapy procedure for treating nasal duct tumors in dogs using a single needle electrode
Autor:Maglietti, F.; Tellado, M.; Olaiz, N.; Michinski, S.; Marshall, G.
Filiación:Universidad de Buenos Aires, Facultad de Ciencias Exactas y Naturales, Departamento de Física, Buenos Aires, Argentina
CONICET-Universidad de Buenos Aires, Instituto de Física Del Plasma (INFIP), Buenos Aires, Argentina
Universidad de Buenos Aires, Facultad de Ciencias Veterinarias, Buenos Aires, Argentina
CONICET-Universidad de Buenos Aires, Facultad de Ciencias Exactas y Naturales, Departamento de Computación, Laboratorio de Sistemas Complejos, Buenos Aires, Argentina
Palabras clave:cancer; canine; electrochemotherapy; electrochemotherapy; nasal cavity; antineoplastic agent; bleomycin; carboplatin; carboplatino delta farma; corticosteroid; adjuvant therapy; Article; controlled study; dog disease; electric field; electrochemotherapy; equipment design; female; follow up; intermethod comparison; male; nonhuman; nose cancer; nose surgery; overall survival; single needle electrode; treatment response
Año:2017
Volumen:51
Número:4
Página de inicio:422
Página de fin:430
DOI: http://dx.doi.org/10.1515/raon-2017-0043
Título revista:Radiology and Oncology
Título revista abreviado:Radiol. Oncol.
ISSN:13182099
CODEN:RONCE
CAS:bleomycin, 11056-06-7, 9041-93-4; carboplatin, 41575-94-4
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_13182099_v51_n4_p422_Maglietti

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Citas:

---------- APA ----------
Maglietti, F., Tellado, M., Olaiz, N., Michinski, S. & Marshall, G. (2017) . Minimally invasive electrochemotherapy procedure for treating nasal duct tumors in dogs using a single needle electrode. Radiology and Oncology, 51(4), 422-430.
http://dx.doi.org/10.1515/raon-2017-0043
---------- CHICAGO ----------
Maglietti, F., Tellado, M., Olaiz, N., Michinski, S., Marshall, G. "Minimally invasive electrochemotherapy procedure for treating nasal duct tumors in dogs using a single needle electrode" . Radiology and Oncology 51, no. 4 (2017) : 422-430.
http://dx.doi.org/10.1515/raon-2017-0043
---------- MLA ----------
Maglietti, F., Tellado, M., Olaiz, N., Michinski, S., Marshall, G. "Minimally invasive electrochemotherapy procedure for treating nasal duct tumors in dogs using a single needle electrode" . Radiology and Oncology, vol. 51, no. 4, 2017, pp. 422-430.
http://dx.doi.org/10.1515/raon-2017-0043
---------- VANCOUVER ----------
Maglietti, F., Tellado, M., Olaiz, N., Michinski, S., Marshall, G. Minimally invasive electrochemotherapy procedure for treating nasal duct tumors in dogs using a single needle electrode. Radiol. Oncol. 2017;51(4):422-430.
http://dx.doi.org/10.1515/raon-2017-0043