Artículo

Zago, M.P.; Mackenzie, G.G.; Adamo, A.M.; Keen, C.L.; Oteiza, P.I. "Differential modulation of MAP kinases by zinc deficiency in IMR-32 cells: Role of H2O2" (2005) Antioxidants and Redox Signaling. 7(11-12):1773-1782
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Abstract:

The influence of zinc deficiency on the modulation of the mitogen-activated protein kinases (MAPKs) extracellular signal-regulated kinase (ERK1/2), p38, and c-Jun N-terminal kinase (JNK) was studied. Using human IMR-32 cells as a model of neuronal cells, the role of oxidants on MAPKs and activator protein-1 (AP-1) activation in zinc deficiency was investigated, characterizing the participation of these events in the triggering of apoptosis. Relative to controls, cells incubated in media with low zinc concentrations showed increased cell oxidants and hydrogen peroxide (H2O2) release, increased JNK and p38 activation, high nuclear AP-1-DNA binding activity, and AP-1-dependent gene expression. Catalase addition to the media prevented the increase of cellular oxidants and inhibited JNK, p38, and AP-1 activation. Low levels of ERK1/2 phosphorylation were observed in the zinc-deficient cells in association with a reduction in cell proliferation. Catalase treatment did not prevent the above events nor the increased rate of apoptosis in the zinc-deficient cells. It is first demonstrated that a decrease in cellular zinc triggers H2O2-independent, as well as H2O 2-dependent effects on MAPKs. Zinc deficiency-induced increases in cellular H2O2 can trigger the activation of JNK and p38, leading to AP-1 activation, events that are not involved in zinc deficiency-induced apoptosis. © Mary Ann Liebert, Inc.

Registro:

Documento: Artículo
Título:Differential modulation of MAP kinases by zinc deficiency in IMR-32 cells: Role of H2O2
Autor:Zago, M.P.; Mackenzie, G.G.; Adamo, A.M.; Keen, C.L.; Oteiza, P.I.
Filiación:Departamento de Química Biológica, Instituto de Química y Fisicoquímica Biológicas (UBA-CONICET), Universidad de Buenos Aires, Buenos Aires, Argentina
Department of Nutrition, University of California Davis, Davis, CA 95616, United States
Department of Environmental Toxicology, University of California Davis, Davis, CA, United States
Department of Internal Medicine, University of California Davis, Davis, CA, United States
Palabras clave:2 (2 amino 3 methoxyphenyl)chromone; 4 (4 fluorophenyl) 2 (4 methylsulfinylphenyl) 5 (4 pyridyl)imidazole; anthra[1,9 cd]pyrazol 6(2h) one; catalase; DNA; hydrogen peroxide; mitogen activated protein kinase; mitogen activated protein kinase 1; mitogen activated protein kinase 3; oxidizing agent; stress activated protein kinase; synaptophysin; transcription factor AP 1; zinc; apoptosis; article; binding affinity; cell proliferation; concentration response; controlled study; enzyme regulation; gene expression regulation; human; human cell; incubation time; nerve cell; priority journal; zinc deficiency; Apoptosis; Catalase; Cell Line; Enzyme Activation; Humans; Hydrogen Peroxide; Mitogen-Activated Protein Kinases; Oxidants; Phosphorylation; Transcription Factor AP-1; Zinc
Año:2005
Volumen:7
Número:11-12
Página de inicio:1773
Página de fin:1782
DOI: http://dx.doi.org/10.1089/ars.2005.7.1773
Título revista:Antioxidants and Redox Signaling
Título revista abreviado:Antioxid. Redox Signal.
ISSN:15230864
CODEN:ARSIF
CAS:2 (2 amino 3 methoxyphenyl)chromone, 167869-21-8; 4 (4 fluorophenyl) 2 (4 methylsulfinylphenyl) 5 (4 pyridyl)imidazole, 152121-47-6; anthra[1,9 cd]pyrazol 6(2h) one, 129-56-6; catalase, 9001-05-2; DNA, 9007-49-2; hydrogen peroxide, 7722-84-1; mitogen activated protein kinase 1, 137632-08-7; mitogen activated protein kinase 3, 137632-07-6; mitogen activated protein kinase, 142243-02-5; stress activated protein kinase, 155215-87-5; zinc, 7440-66-6; Catalase, EC 1.11.1.6; Hydrogen Peroxide, 7722-84-1; Mitogen-Activated Protein Kinases, EC 2.7.1.37; Oxidants; Transcription Factor AP-1; Zinc, 7440-66-6
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_15230864_v7_n11-12_p1773_Zago

Referencias:

  • Beyersmann, D., Haase, H., Functions of zinc in signaling, proliferation and differentiation of mammalian cells (2001) Biometals, 14, pp. 331-341
  • Blanc, A., Pandey, N.R., Srivastava, A.K., Distinct roles of Ca2+, calmodulin, and protein kinase C in H2O2-induced activation of ERK1/2, p38 MAPK, and protein kinase B signaling in vascular smooth muscle cells (2004) Antioxid Redox Signal, 6, pp. 353-366
  • Cao, Q., Mak, K.M., Ren, C., Lieber, C.S., Leptin stimulates tissue inhibitor of metalloproteinase-1 in human hepatic stellate cells: Respective roles of the JAK/STAT and JAK-mediated H 2O2-dependant MAPK pathways (2004) J Biol Chem, 279, pp. 4292-4304
  • Chaturvedi, R., Cheng, Y., Asim, M., Bussiere, F.I., Xu, H., Gobert, A.P., Hacker, A., Wilson, K.T., Induction of polyamine oxidase 1 by Helicobacter pylori causes macrophage apoptosis by hydrogen peroxide release and mitochondrial membrane depolarization (2004) J Biol Chem, 279, pp. 40161-40173
  • Chomczynski, P., Sacchi, N., Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction (1987) Anal Biochem, 162, pp. 156-159
  • Dignam, J.D., Lebovitz, R.M., Roeder, R.G., Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei (1983) Nucleic Acids Res, 11, pp. 1475-1489
  • Ding, M., Shi, X., Lu, Y., Huang, C., Leonard, S., Roberts, J., Antonini, J., Vallyathan, V., Induction of activator protein-1 through reactive oxygen species by crystalline silica in JB6 cells (2001) J Biol Chem, 276, pp. 9108-9114
  • Duffy, J.Y., Miller, C.M., Rutschilling, G.L., Ridder, G.M., Clegg, M.S., Keen, C.L., Daston, G.P., A decrease in intracellular zinc level precedes the detection of early indicators of apoptosis in HL-60 cells (2001) Apoptosis, 6, pp. 161-172
  • Finkel, T., Oxygen radicals and signaling (1998) Curr Opin Cell Biol, 10, pp. 248-253
  • Fraker, P.J., Telford, W.G., A reappraisal of the role of zinc in life and death decisions of cells (1997) Proc Soc Exp Biol Med, 215, pp. 229-236
  • Guyton, K.Z., Liu, Y., Gorospe, M., Xu, Q., Holbrook, N.J., Activation of mitogen-activated protein kinase by H2O 2. Role in cell survival following oxidant injury (1996) J Biol Chem, 271, pp. 4138-4142
  • Hecht, D., Zick, Y., Selective inhibition of protein tyrosine phosphatase activities by H 2O2 and vanadate in vitro (1992) Biochem Biophys Res Commun, 188, pp. 773-779
  • Ho, E., Ames, B.N., Low intracellular zinc induces oxidative DNA damage, disrupts p53, NFkappa B, and AP1 DNA binding, and affects DNA repair in a rat glioma cell line (2002) Proc Natl Acad Sci U S A, 99, pp. 16770-16775
  • Jankowski-Hennig, M.A., Clegg, M.S., Daston, G.P., Rogers, J.M., Keen, C.L., Zinc-deficient rat embryos have increased caspase 3-like activity and apoptosis (2000) Biochem Biophys Res Commun, 271, pp. 250-256
  • Karin, M., Shaulian, E., AP-1: Linking hydrogen peroxide and oxidative stress to the control of cell proliferation and death (2001) IUBMB Life, 52, pp. 17-24
  • Karin, M., Takahashi, T., Kapahi, P., Delhase, M., Chen, Y., Makris, C., Rothwarf, D., Li, N., Oxidative stress and gene expression: The AP-1 and NF-kappaB connections (2001) Biofactors, 15, pp. 87-89
  • Keen, C.L., Clegg, M.S., Hanna, L.A., Lanoue, L., Rogers, J.M., Daston, G.P., Oteiza, P., Uriu-Adams, J.Y., The plausibility of micronutrient deficiencies being a significant contributing factor to the occurrence of pregnancy complications (2003) J Nutr, 133, pp. 15978-16058
  • Mackenzie, G.G., Keen, C.L., Oteiza, P.I., Zinc status of human IMR-32 neuroblastoma cells influences their susceptibility to iron-induced oxidative stress (2002) Dev Neurosci, 24, pp. 125-133
  • Mackenzie, G.G., Zago, M.P., Keen, C.L., Oteiza, P.I., Low intracellular zinc impairs the translocation of activated NF-kappa B to the nuclei in human neuroblastoma IMR-32 cells (2002) J Biol Chem, 277, pp. 34610-34617
  • Osborn, L., Kunkel, S., Nabel, G.J., Tumor necrosis factor alpha and interleukin 1 stimulate the human immunodeficiency virus enhancer by activation of the nuclear factor kappa B (1989) Proc Natl Acad Sci U S A, 86, pp. 2336-2340
  • Oteiza, P.I., Olin, K.L., Fraga, C.G., Keen, C.L., Zinc deficiency causes oxidative damage to proteins, lipids and DNA in rat testes (1995) J Nutr, 125, pp. 823-829
  • Oteiza, P.I., Clegg, M.S., Zago, M.P., Keen, C.L., Zinc deficiency induces oxidative stress and AP-1 activation in 3T3 cells (2000) Free Radic Biol Med, 28, pp. 1091-1099
  • Rincon, M., Flavell, R.A., Davis, R.J., Signal transduction by MAP kinases in T lymphocytes (2001) Oncogene, 20, pp. 2490-2497
  • Rodriguez-Puyol, M., Griera-Merino, M., Perez-Rivero, G., Diez-Marques, M.L., Ruiz-Torres, M.P., Rodriguez-Puyol, D., Angiotensin II induces a rapid and transient increase of reactive oxygen species (2002) Antioxid Redox Signal, 4, pp. 869-875
  • Saitoh, M., Nishitoh, H., Fujii, M., Takeda, K., Tobiume, K., Sawada, Y., Kawabata, M., Ichijo, H., Mammalian thioredoxin is a direct inhibitor of apoptosis signal-regulating kinase (ASK) 1 (1998) EMBO J, 17, pp. 2596-2606
  • Shaulian, E., Karin, M., AP-1 as a regulator of cell life and death (2002) Nat Cell Biol, 4, pp. E131-E136
  • Steelman, L.S., Pohnert, S.C., Shelton, J.G., Franklin, R.A., Bertrand, F.E., McCubrey, J.A., JAK/STAT, Raf/MEK/ ERK, PI3K/Akt and BCR-ABL in cell cycle progression and leukemogenesis (2004) Leukemia, 18, pp. 189-218
  • Szatrowski, T.P., Nathan, C.F., Production of large amounts of hydrogen peroxide by human tumor cells (1991) Cancer Res, 51, pp. 794-798
  • Toone, W.M., Morgan, B.A., Jones, N., Redox control of AP-1-like factors in yeast and beyond (2001) Oncogene, 20, pp. 2336-2346
  • Truong-Tran, A.Q., Grosser, D., Ruffin, R.E., Murgia, C., Zalewski, P.D., Apoptosis in the normal and inflamed airway epithelium: Role of zinc in epithelial protection and procaspase-3 regulation (2003) Biochem Pharmacol, 66, pp. 1459-1468
  • Verstraeten, S.V., Zago, M.P., Mackenzie, G.G., Keen, C.L., Oteiza, P.I., Influence of zinc deficiency on cell-membrane fluidity in Jurkat, 3T3 and IMR-32 cells (2004) Biochem J, 378, pp. 579-587
  • (2002) The World Health Report: Reducing Risks, Promoting Healthy Life, , World Health Organization; Geneva, Switzerland

Citas:

---------- APA ----------
Zago, M.P., Mackenzie, G.G., Adamo, A.M., Keen, C.L. & Oteiza, P.I. (2005) . Differential modulation of MAP kinases by zinc deficiency in IMR-32 cells: Role of H2O2. Antioxidants and Redox Signaling, 7(11-12), 1773-1782.
http://dx.doi.org/10.1089/ars.2005.7.1773
---------- CHICAGO ----------
Zago, M.P., Mackenzie, G.G., Adamo, A.M., Keen, C.L., Oteiza, P.I. "Differential modulation of MAP kinases by zinc deficiency in IMR-32 cells: Role of H2O2" . Antioxidants and Redox Signaling 7, no. 11-12 (2005) : 1773-1782.
http://dx.doi.org/10.1089/ars.2005.7.1773
---------- MLA ----------
Zago, M.P., Mackenzie, G.G., Adamo, A.M., Keen, C.L., Oteiza, P.I. "Differential modulation of MAP kinases by zinc deficiency in IMR-32 cells: Role of H2O2" . Antioxidants and Redox Signaling, vol. 7, no. 11-12, 2005, pp. 1773-1782.
http://dx.doi.org/10.1089/ars.2005.7.1773
---------- VANCOUVER ----------
Zago, M.P., Mackenzie, G.G., Adamo, A.M., Keen, C.L., Oteiza, P.I. Differential modulation of MAP kinases by zinc deficiency in IMR-32 cells: Role of H2O2. Antioxid. Redox Signal. 2005;7(11-12):1773-1782.
http://dx.doi.org/10.1089/ars.2005.7.1773