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Abstract:

Nothing is known about the possible effect of thymol or other compounds of essential oils against the adult worms of cestodes. The aim of the present work was to determine in vitro cestodicidal activity of thymol against Mesocestoides corti adult worms. Moreover, the in vitro effect on tetrathyridia was also demonstrated. Tetrathyridia exposed to different concentrations of thymol showed a concentration and time-dependent effect. At lower concentrations, the main change observed was mainly in morphology, with larvae exhibiting an elongation of the body. When tetrathyridia were exposed to higher concentrations, increased surface alterations and damage were detected. The body appeared elongated and flattened, and a complete loss of morphology and microtriches was observed. Thymol was able to kill M. corti tetrathyridia, since following inoculation of treated parasites in mice no parasites could be recovered. The effect on M. corti adult worms was dose and time-dependent. Changes in motility coincide with the tissue damage were observed at the structural and ultrastructural level. Thymol caused severe damages to both developmental stages analyzed. Damages were more significant in fully segmented worms. The data reported in this paper demonstrate a clear in vitro effect of thymol against M. corti tetrathyridia and adult worms. © 2014 M. Maggiore and M. C. Elissondo.

Registro:

Documento: Artículo
Título:In vitro cestocidal activity of thymol on Mesocestoides corti tetrathyridia and adult worms
Autor:Maggiore, M.; Elissondo, M.C.
Filiación:Laboratorio de Zoonosis Parasitarias, Departamento de Biología, Facultad de Ciencias Exactas y Naturales, Universidad Nacional de Mar Del Plata (UNMdP), 3350 Funes Street, Mar del Plata, Argentina
Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Buenos Aires, Argentina
Palabras clave:thymol; adult; animal experiment; animal model; animal tissue; antimicrobial activity; Article; cestocidal activity; cestodiasis; concentration response; controlled study; developmental stage; drug efficacy; female; in vitro study; larva; Mesocestoidea; Mesocestoides corti; morphology; mouse; nonhuman; priority journal; rat; tetrathyridium; tissue injury; ultrastructure
Año:2014
Volumen:2014
DOI: http://dx.doi.org/10.1155/2014/268135
Título revista:Interdisciplinary Perspectives on Infectious Diseases
Título revista abreviado:Interdiscip. Perspect. Infect. Dis.
ISSN:1687708X
CAS:thymol, 89-83-8
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_1687708X_v2014_n_p_Maggiore

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Citas:

---------- APA ----------
Maggiore, M. & Elissondo, M.C. (2014) . In vitro cestocidal activity of thymol on Mesocestoides corti tetrathyridia and adult worms. Interdisciplinary Perspectives on Infectious Diseases, 2014.
http://dx.doi.org/10.1155/2014/268135
---------- CHICAGO ----------
Maggiore, M., Elissondo, M.C. "In vitro cestocidal activity of thymol on Mesocestoides corti tetrathyridia and adult worms" . Interdisciplinary Perspectives on Infectious Diseases 2014 (2014).
http://dx.doi.org/10.1155/2014/268135
---------- MLA ----------
Maggiore, M., Elissondo, M.C. "In vitro cestocidal activity of thymol on Mesocestoides corti tetrathyridia and adult worms" . Interdisciplinary Perspectives on Infectious Diseases, vol. 2014, 2014.
http://dx.doi.org/10.1155/2014/268135
---------- VANCOUVER ----------
Maggiore, M., Elissondo, M.C. In vitro cestocidal activity of thymol on Mesocestoides corti tetrathyridia and adult worms. Interdiscip. Perspect. Infect. Dis. 2014;2014.
http://dx.doi.org/10.1155/2014/268135