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Abstract:

Conjugation with polyethylene glycol (PEG), known as PEGylation, has been widely used to improve the bioavailability of proteins and low molecular weight drugs. The covalent conjugation of PEG to the carbohydrate moiety of a protein has been mainly used to enhance the pharmacokinetic properties of the attached protein while yielding a more defined product. Thus, glycoPEGylation was successfully applied to the introduction of a PEGylated sialic acid to a preexisting or enzymatically linked glycan in a protein. Carbohydrates are now recognized as playing an important role in host-pathogen interactions in protozoal, bacterial and viral infections and are consequently candidates for chemotherapy. The short in vivo half-life of low molecular weight glycans hampered their use but methods for the covalent attachment of PEG have been less exploited. In this review, information on the preparation and application of PEG-carbohydrates, in particular multiarm PEGylation, is presented. © 2014 Giorgi et al.

Registro:

Documento: Artículo
Título:Carbohydrate PEGylation, an approach to improve pharmacological potency
Autor:Giorgi, M.E.; Agusti, R.; De Lederkremer, R.M.
Filiación:CIHIDECAR-CONICET, Departamento de Química Orgánica, Universidad de Buenos Aires, Pabellón II, Ciudad Universitaria, 1428 Buenos Aires, Argentina
Palabras clave:Bioavailability; Carbohydrates; Conjugates; Glycopegylation; Multivalent glycosystems; Multivalent PEGylation
Año:2014
Volumen:10
Página de inicio:1433
Página de fin:1444
DOI: http://dx.doi.org/10.3762/bjoc.10.147
Título revista:Beilstein Journal of Organic Chemistry
Título revista abreviado:Beilstein J. Org. Chem.
ISSN:18605397
CODEN:BJOCB
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_18605397_v10_n_p1433_Giorgi

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Citas:

---------- APA ----------
Giorgi, M.E., Agusti, R. & De Lederkremer, R.M. (2014) . Carbohydrate PEGylation, an approach to improve pharmacological potency. Beilstein Journal of Organic Chemistry, 10, 1433-1444.
http://dx.doi.org/10.3762/bjoc.10.147
---------- CHICAGO ----------
Giorgi, M.E., Agusti, R., De Lederkremer, R.M. "Carbohydrate PEGylation, an approach to improve pharmacological potency" . Beilstein Journal of Organic Chemistry 10 (2014) : 1433-1444.
http://dx.doi.org/10.3762/bjoc.10.147
---------- MLA ----------
Giorgi, M.E., Agusti, R., De Lederkremer, R.M. "Carbohydrate PEGylation, an approach to improve pharmacological potency" . Beilstein Journal of Organic Chemistry, vol. 10, 2014, pp. 1433-1444.
http://dx.doi.org/10.3762/bjoc.10.147
---------- VANCOUVER ----------
Giorgi, M.E., Agusti, R., De Lederkremer, R.M. Carbohydrate PEGylation, an approach to improve pharmacological potency. Beilstein J. Org. Chem. 2014;10:1433-1444.
http://dx.doi.org/10.3762/bjoc.10.147