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Abstract:

Background: Previously, we have shown there is clinal variation for egg-to-adult developmental time along geographic gradients in Drosophila melanogaster. Further, we also have identified mutations in genes involved in metabolic and neurogenic pathways that affect development time (heterochronic genes). However, we do not know whether these loci affect variation in developmental time in natural populations. Methodology/Principal Findings: Here, we constructed second chromosome substitution lines from natural populations of Drosophila melanogaster from an altitudinal cline, and measured egg-adult development time for each line. We found not only a large amount of genetic variation for developmental time, but also positive associations of the development time with thermal amplitude and altitude. We performed genetic complementation tests using substitution lines with the longest and shortest developmental times and heterochronic mutations. We identified segregating variation for neurogenic and metabolic genes that largely affected the duration of the larval stages but had no impact on the timing of metamorphosis. Conclusions/Significance: Altitudinal clinal variation in developmental time for natural chromosome substitution lines provides a unique opportunity to dissect the response of heterochronic genes to environmental gradients. Ontogenetic stage-specific variation in invected, mastermind, cricklet and CG14591 may affect natural variation in development time and thermal evolution. © 2010 Mensch et al.

Registro:

Documento: Artículo
Título:Stage-specific effects of candidate heterochronic genes on variation in developmental time along an altitudinal cline of Drosophila melanogaster
Autor:Mensch, J.; Carreira, V.; Lavagnino, N.; Goenaga, J.; Folguera, G.; Hasson, E.; Fanara, J.J.
Filiación:Laboratorio de Evolución, Departamento de Ecología, Genética y Evolucien, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina
Palabras clave:cricklet protein; gene product; invected protein; mastermind protein; protein CG14591; unclassified drug; altitude acclimatization; animal cell; article; chromosome substitution; controlled study; developmental stage; Drosophila melanogaster; female; genetic complementation; genetic variability; larval stage; metamorphosis; nonhuman; oocyte development; thermal stimulation
Año:2010
Volumen:5
Número:6
Página de inicio:1
Página de fin:10
DOI: http://dx.doi.org/10.1371/journal.pone.0011229
Título revista:PLoS ONE
Título revista abreviado:PLoS ONE
ISSN:19326203
CODEN:POLNC
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_19326203_v5_n6_p1_Mensch

Referencias:

  • Stearns, S.C., (1992) The Evolution of Life Histories, p. 264. , New York: Oxford University Press
  • Chippindale, A.K., Alipaz, J.A., Chen, H., Rose, M., Experimental evolution of accelerated development in Drosophila. 1. Developmental speed and larval survival (1997) Evolution, 51, pp. 1536-1551
  • Prasad, N.G., Shakarad, M., Anitha, D., Rajamani, M., Joshi, A., Correlated responses to selection for faster development and early reproduction in Drosophila: The evolution of larval traits (2001) Evolution, 55, pp. 1363-1372
  • Nunney, L., The response to selection for fast larval development in Drosophila melanogaster and its effect on adult weight: An example of a fitness trade-off (1996) Evolution, 50, pp. 1193-1204
  • Chippindale, A.K., Alipaz, J.A., Rose, M.R., Experimental evolution of accelerated development in Drosophila. 2. Adult fitness and the fast development syndrome (2004) Methuselah Flies: A Case Study In the Evolution of Aging, pp. 413-435. , In: Rose MR, Passananti HB, Matos M, eds., Singapore: World Scientific Publishing
  • Harshman, L.G., Hoffmann, A.A., Clark, A.G., Selection for starvation resistance in Drosophila melanogaster: Physiological correlates, enzyme activities and multiple stress responses (1999) J Evol Biol, 12, pp. 370-379
  • James, A.C., Partridge, L., Thermal evolution of the rate of larval development in Drosophila melanogaster in laboratory and fields populations (1995) J Evol Biol, 8, pp. 315-330
  • Folguera, G., Ceballos, S., Spezzi, L., Fanara, J.J., Hasson, E., Clinal variation in developmental time and viability, and the response to thermal treatments in two species of Drosophila (2008) Biol J Linn Soc, 95, pp. 233-245
  • Van't Land, J., van Putten, P., Zwaan, B., Kamping, A., van Delden, W., Latitudinal variation in wild populations of Drosophila melanogaster: Heritabilities and reaction norms (1999) J Evol Biol, 12, pp. 222-232
  • Mensch, J., Lavagnino, N., Carreira, V.P., Massaldi, A., Hasson, E., Identifying candidate genes affecting developmental time in Drosophila melanogaster: Pervasive pleiotropy and gene-by-environment interaction (2008) BMC Dev Biol, 8, p. 78
  • de Jong, G., Bochdanovits, Z., Latitudinal clines in Drosophila melanogaster: Body size, allozyme frequencies, inversion frequencies, and the insulin-signalling pathway (2003) J Genet, 82, pp. 207-223
  • van Delden, W., Kamping, A., Changes in relative fitness with temperature among second chromosome arrangements in Drosophila melanogaster (1991) Genetics, 127, pp. 507-514
  • Gustavson, E., Goldsborough, A.S., Ali, Z., Kornberg, T.B., The Drosophila engrailed and invected genes: Partners in regulation, expression and function (1996) Genetics, 142, pp. 893-906
  • Bettler, D., Pearson, S., Yedvobnick, B., The nuclear protein encoded by the Drosophila neurogenic gene mastermind is widely expressed and associates with specific chromosomal regions (1996) Genetics, 143, pp. 859-875
  • Campbell, P.M., Harcourt, R.L., Crone, E.J., Claudianos, C., Hammock, B.D., Identification of a juvenile hormone esterase gene by matching its peptide mass fingerprint with a sequence from the Drosophila genome project (2001) Insect Biochem Mol Biol, 31, pp. 513-520
  • Mackay, T.F., Complementing complexity (2004) Nat Genet, 36, pp. 1145-1147
  • Paaby, A.B., Schmidt, P.S., Functional significance of allelic variation at methuselah, an aging gene in Drosophila (2008) PLoS One, 3, pp. e1987
  • Edwards, A.C., Mackay, T.F., Quantitative trait loci for aggressive behavior in Drosophila melanogaster (2009) Genetics, 182, pp. 889-897
  • Geiger-Thornsberry, G.L., Mackay, T.F., Quantitative trait loci affecting natural variation in Drosophila longevity (2004) Mech Ageing Dev, 125, pp. 179-189
  • Soto, E.M., Soto, I.M., Carreira, V.P., Fanara, J.J., Hasson, E., Host-related life history traits in interspecific hybrids of cactophilic Drosophila (2008) Entomologia Experimentalis Et Applicata, 126, pp. 18-27
  • Fanara, J.J., Folguera, G., Iriarte, P.F., Mensch, J., Hasson, E., Genotype by environment interactions in viability and developmental time in populations of cactophilic Drosophila (2006) J Evol Biol, 19, pp. 900-908
  • Mackay, T.F., Quantitative trait loci in Drosophila (2001) Nat Rev Genet, 2, pp. 11-20
  • Anholt, R.R., Mackay, T.F., Quantitative genetic analyses of complex behaviours in Drosophila (2004) Nat Rev Genet, 5, pp. 838-849
  • Fanara, J.J., Robinson, K.O., Rollmann, S.M., Anholt, R.R., Mackay, T.F., Vanaso is a candidate quantitative trait gene for Drosophila olfactory behaviour (2002) Genetics, 162, pp. 1321-1328
  • Harbison, S.T., Chang, S., Kamdar, K.P., Mackay, T.F., Quantitative genomics of starvation stress resistance in Drosophila (2005) Genome Biol, 6, pp. R36
  • Jordan, K.W., Carbone, M.A., Yamamoto, A., Morgan, T.J., Mackay, T.F., Quantitative genomics of locomotor behavior in Drosophila melanogaster (2007) Genome Biol, 8, pp. R172
  • Wang, P., Lyman, R.F., Shabalina, S.A., Mackay, T.F., Anholt, R.R., Association of polymorphisms in odorant-binding protein genes with variation in olfactory response to benzaldehyde in Drosophila (2007) Genetics, 177, pp. 1655-1665
  • Schmid, A.T., Tinley, T.L., Yedvobnick, B., Transcription of the neurogenic gene mastermind during Drosophila development (1996) J Exp Zool, 274, pp. 207-220
  • Crone, E.J., Sutherland, T.D., Campbell, P.M., Coppin, C.W., Russell, R.J., Only one esterase of Drosophila melanogaster is likely to degrade juvenile hormone in vivo (2007) Insect Biochem Mol Biol, 37, pp. 540-549
  • Gotthard, K., Growth strategies of ectothermic animals in temperate environments (2001) Environmental and Animal Development, pp. 287-304. , In: Atkinson D, Thorndyke M, eds., Oxford: BIOS Scientific Publishers
  • Davidowitz, G., Nijhout, H.F., The physiological basis of reaction norms: The interaction between growth rate, the duration of growth and body size (2004) Integrative and Comparative Biology, 44, pp. 443-449
  • Nunney, L., Pupal period and adult size in Drosophila melanogaster: A cautionary tale of contrasting correlations between two sexually dimorphic traits (2007) J Evol Biol, 20, pp. 141-151
  • Edgar, B., How flies get their size: Genetics meets physiology (2006) Nat Rev Genet, 7, pp. 907-916
  • Carreira, V., Mensch, J., Fanara, J.J., Body size in Drosophila: Genetic architecture, allometries and sexual dimorphism (2009) Heredity, 102, pp. 246-256
  • Mackay, T.F., Richards, S., Gibbs, R., (2008) Proposal to Sequence a Drosophila Genetic Reference Panel: A Community Resource For the Study of Genotypic and Phenotypic Variation, , http://flybase.org/static_pages/news/whitepapers/Drosophila_Genetic_Reference_Panel_Whitepaper.pdf, Available, Accessed 2010 April 9
  • Evolution of genes and genomes on the Drosophila phylogeny (2007) Nature, 450, pp. 203-218. , Drosophila 12 Genomes Consortium

Citas:

---------- APA ----------
Mensch, J., Carreira, V., Lavagnino, N., Goenaga, J., Folguera, G., Hasson, E. & Fanara, J.J. (2010) . Stage-specific effects of candidate heterochronic genes on variation in developmental time along an altitudinal cline of Drosophila melanogaster. PLoS ONE, 5(6), 1-10.
http://dx.doi.org/10.1371/journal.pone.0011229
---------- CHICAGO ----------
Mensch, J., Carreira, V., Lavagnino, N., Goenaga, J., Folguera, G., Hasson, E., et al. "Stage-specific effects of candidate heterochronic genes on variation in developmental time along an altitudinal cline of Drosophila melanogaster" . PLoS ONE 5, no. 6 (2010) : 1-10.
http://dx.doi.org/10.1371/journal.pone.0011229
---------- MLA ----------
Mensch, J., Carreira, V., Lavagnino, N., Goenaga, J., Folguera, G., Hasson, E., et al. "Stage-specific effects of candidate heterochronic genes on variation in developmental time along an altitudinal cline of Drosophila melanogaster" . PLoS ONE, vol. 5, no. 6, 2010, pp. 1-10.
http://dx.doi.org/10.1371/journal.pone.0011229
---------- VANCOUVER ----------
Mensch, J., Carreira, V., Lavagnino, N., Goenaga, J., Folguera, G., Hasson, E., et al. Stage-specific effects of candidate heterochronic genes on variation in developmental time along an altitudinal cline of Drosophila melanogaster. PLoS ONE. 2010;5(6):1-10.
http://dx.doi.org/10.1371/journal.pone.0011229