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Abstract:

Splicing is a predominantly co-transcriptional process that has been shown to be tightly coupled to transcription. Chromatin structure is a key factor that mediates this functional coupling. In light of recent evidence that shows the importance of higher order chromatin organization in the coordination and regulation of gene expression, we discuss here the possible roles of long-range chromatin organization in splicing and alternative splicing regulation. © 2014 Landes Bioscience.

Registro:

Documento: Artículo
Título:Long range chromatin organization: A new layer in splicing regulation?
Autor:Gómez Acuña, L.I.; Kornblihtt, A.R.
Filiación:Laboratorio de Fisiología y Biología Molecular, Departamento de Fisiología, Biología Molecular y Celular, IFIBYNE-CONICET, Universidad de Buenos Aires, Buenos Aires, Argentina
Palabras clave:Alternative splicing; Chromatin; Coupling between transcription and splicing; Long-range chromatin interactions; cohesin; estradiol receptor; heterogeneous nuclear ribonucleoprotein L; histone; polycomb group protein; RNA polymerase II; transcription factor CTCF; chromatin; alternative RNA splicing; article; chromatin structure; DNA methylation; DNA template; embryonic stem cell; enhancer region; fibroblast; gene activation; genetic association; globin gene; human; promoter region; regulator gene; transcription initiation; animal; chromatin; genetic transcription; metabolism; RNA splicing; Animals; Chromatin; Humans; RNA Splicing; Transcription, Genetic
Año:2014
Volumen:5
Número:APR
Página de inicio:e28726
Página de fin:1-e28726-5
DOI: http://dx.doi.org/10.4161/trns.28726
Título revista:Transcription
Título revista abreviado:Transcription
ISSN:21541264
CAS:histone, 9062-68-4; Chromatin
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_21541264_v5_nAPR_pe28726_GomezAcuna

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Citas:

---------- APA ----------
Gómez Acuña, L.I. & Kornblihtt, A.R. (2014) . Long range chromatin organization: A new layer in splicing regulation?. Transcription, 5(APR), e28726-1-e28726-5.
http://dx.doi.org/10.4161/trns.28726
---------- CHICAGO ----------
Gómez Acuña, L.I., Kornblihtt, A.R. "Long range chromatin organization: A new layer in splicing regulation?" . Transcription 5, no. APR (2014) : e28726-1-e28726-5.
http://dx.doi.org/10.4161/trns.28726
---------- MLA ----------
Gómez Acuña, L.I., Kornblihtt, A.R. "Long range chromatin organization: A new layer in splicing regulation?" . Transcription, vol. 5, no. APR, 2014, pp. e28726-1-e28726-5.
http://dx.doi.org/10.4161/trns.28726
---------- VANCOUVER ----------
Gómez Acuña, L.I., Kornblihtt, A.R. Long range chromatin organization: A new layer in splicing regulation?. Transcription. 2014;5(APR):e28726-1-e28726-5.
http://dx.doi.org/10.4161/trns.28726