Identificador para citar o enlazar este ítem: http://hdl.handle.net/20.500.13003/13676
DBP rs16846876 and rs12512631 polymorphisms are associated with progression to AIDS naive HIV-infected patients: a retrospective study
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ISSN: 1021-7770
eISSN: 1423-0127
WOS ID: 000491993500001
Scopus EID: 2-s2.0-85073735250
PMID: 31640710
Embase PUI: L629851003
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2019-10-23Tipo de documento
research articleCitación
Jimenez-Sousa MA, Jimenez JL, Fernandez-Rodriguez A, Bellon JM, Rodriguez C, Riera M, et al. DBP rs16846876 and rs12512631 polymorphisms are associated with progression to AIDS naive HIV-infected patients: a retrospective study. J Biomed Sci. 2019 Oct 23;26(1):83.Resumen
Background Most of the circulating Vitamin D (VitD) is transported bound to vitamin D-binding protein (DBP), and several DBP single nucleotide polymorphisms (SNPs) have been related to circulating VitD concentration and disease. In this study, we evaluated the association among DBP SNPs and AIDS progression in antiretroviral treatment (ART)-naive-HIV-infected patients. Methods We performed a retrospective study in 667 patients who were classified according to their pattern of AIDS progression (183 long-term non-progressors (LTNPs), 334 moderate progressors (MPs), and 150 rapid progressors (RPs)) and 113 healthy blood donors (HIV, HCV, and HBV negative subjects). We genotyped seven DBP SNPs (rs16846876, rs12512631, rs2070741, rs2282679, rs7041, rs1155563, rs2298849) using Agena Bioscience's MassARRAY platform. The genetic association was evaluated by Generalized Linear Models adjusted by age at the moment of HIV diagnosis, gender, risk group, and VDR rs2228570 SNP. Multiple testing correction was performed by the false discovery rate (Benjamini and Hochberg procedure; q-value). Results All SNPs were in HWE (p > 0.05) and had similar genotypic frequencies for DBP SNPs in healthy-controls and HIV-infected patients. In unadjusted GLMs, we only found significant association with AIDS progression in rs16846876 and rs12512631 SNPs. In adjusted GLMs, DBP rs16846876 SNP showed significant association under the recessive inheritance model [LTNPs vs. RPs (adjusted odds ratio (aOR) = 3.53; q-value = 0.044) and LTNPs vs. MPs (aOR = 3.28; q-value = 0.030)] and codominant [LTNPs vs. RPs (aOR = 4.92; q-value = 0.030) and LTNPs vs. MPs (aOR = 3.15; q-value = 0.030)]. Also, we found DBP rs12512631 SNP showed significant association in the inheritance model dominant [LTNPs vs. RPs (aOR = 0.49; q-value = 0.031) and LTNPs vs. MPs (aOR = 0.6; q-value = 0.047)], additive [LTNPs vs. RPs (aOR = 0.61; q-value = 0.031)], overdominant [LTNPs vs. MPs (aOR = 0.55; q-value = 0.032)], and codominant [LTNPs vs. RPs (aOR = 0.52; q-value = 0.036) and LTNPs vs. MPs (aOR = 0.55; q-value = 0.032)]. Additionally, we found a significant association between DBP haplotypes (composed by rs16846876 and rs12512631) and AIDS progression (LTNPs vs RPs): DBP haplotype AC (aOR = 0.63; q-value = 0.028) and the DBP haplotype TT (aOR = 1.64; q-value = 0.028). Conclusions DBP rs16846876 and rs12512631 SNPs are related to the patterns of clinical AIDS progression (LTNP, MP, and RP) in ART-naive HIV-infected patients. Our findings provide new knowledge about AIDS progression that may be relevant to understanding the pathogenesis of HIV infection.
Versión del editor
https://dx.doi.org/10.1186/s12929-019-0577-yPalabras clave
Single nucleotide polymorphismsDBP
LTNPs
AIDS
Non-progression
MeSH
Disease ProgressionSpain
Adult
Anti-Retroviral Agents
Acquired Immunodeficiency Syndrome
DNA-Binding Proteins
Humans
HIV
Middle Aged
Polymorphism, Single Nucleotide
Male
Female
Cohort Studies
Retrospective Studies
Transcription Factors
DeCS
Estudios de CohortesFactores de Transcripción
Polimorfismo de Nucleótido Simple
Antirretrovirales
Femenino
Masculino
Síndrome de Inmunodeficiencia Adquirida
Proteínas de Unión al ADN
Humanos
Persona de Mediana Edad
VIH
Progresión de la Enfermedad
Estudios Retrospectivos
Adulto
España
Colecciones de Docusalut en las que aparece este ítem
Hospital Universitario Son Espases - HUSE > Comunicación científicaInstituto de Investigación Sanitaria Islas Baleares - IDISBA > Comunicación científica