Identificador para citar o enlazar este ítem: http://hdl.handle.net/20.500.13003/15915
Differential Proinflammatory Signature in Vestibular Migraine and Meniere Disease
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ISSN: 1664-3224
WOS ID: 000470196500002
Scopus EID: 2-s2.0-85069213887
PMID: 31214186
Embase PUI: L628505044
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Flook, Marisa; Frejo, Lidia; Gallego-Martinez, Alvaro; Martin-Sanz, Eduardo; Rossi-Izquierdo, Marcos; Amor-Dorado, Juan Carlos ; Soto-Varela, Andres; Santos-Perez, Sofia; Batuecas-Caletrio, Angel; Manuel Espinosa-Sanchez, Juan; Perez-Carpena, Patricia; Martinez-Martinez, Marta; Aran, Ismael; Antonio Lopez-Escamez, JoseFecha de publicación
2019-06-04Tipo de documento
research articleCitación
Flook M, Frejo L, Gallego-Martinez A, Martin-Sanz E, Rossi-Izquierdo M, Amor-Dorado JC, et al. Differential Proinflammatory Signature in Vestibular Migraine and Meniere Disease. Front Immunol. 2019 Jun 04;10:1229.Resumen
Vestibular Migraine (VM) and Meniere's Disease (MD) are episodic vestibular syndromes defined by a set of associated symptoms such as tinnitus, hearing loss or migraine features during the attacks. Both conditions may show symptom overlap and there is no biological marker to distinguish them. Two subgroups of MD patients have been reported, according to their IL-1 beta profile. Therefore, considering the clinical similarity between VM and MD, we aimed to investigate the cytokine profile of MD and VM as a means to distinguish these patients. We have also carried out gene expression microarrays and measured the levels of 14 cytokines and 11 chemokines in 129 MD patients, 82 VM patients, and 66 healthy controls. Gene expression profile in peripheral blood mononuclear cells (PBMC) showed significant differences in MD patients with high and low basal levels of IL-1 beta and VM patients. MD patients with high basal levels of IL- 1 beta (MDH) had overall higher levels of cytokines/chemokines when compared to the other subsets. CCL4 levels were significantly different between MDH, MD with low basal levels of IL- 1 beta (MDL), VM and controls. Logistic regression identified IL- 1 beta, CCL3, CCL22, and CXCL1 levels as capable of differentiating VM patients from MD patients (area under the curve = 0.995), suggesting a high diagnostic value in patients with symptoms overlap.
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https://dx.doi.org/10.3389/fimmu.2019.01229Palabras clave
Vestibular MigraineMeniere Disease
differential diagnosis
IL-1 beta
CXCL1
CCL3
CCL22
MeSH
Area Under CurveAged
Diagnosis, Differential
Case-Control Studies
Adult
Computational Biology
Symptom Assessment
Humans
Disease Susceptibility
Leukocytes, Mononuclear
Middle Aged
Meniere Disease
Male
Migraine Disorders
Biomarkers
Cytokines
Inflammation Mediators
Female
Gene Expression Profiling
Gene Regulatory Networks
Age of Onset
DeCS
Mediadores de InflamaciónBiomarcadores
Citocinas
Edad de Inicio
Trastornos Migrañosos
Femenino
Enfermedad de Meniere
Susceptibilidad a Enfermedades
Evaluación de Síntomas
Masculino
Humanos
Persona de Mediana Edad
Leucocitos Mononucleares
Anciano
Biología Computacional
Adulto
Redes Reguladoras de Genes
Perfilación de la Expresión Génica
Área Bajo la Curva
Estudios de Casos y Controles
Diagnóstico Diferencial