Identificador para citar o enlazar este ítem: http://hdl.handle.net/20.500.13003/17053
A nomogram for predicting complications in patients with solid tumours and seemingly stable febrile neutropenia
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DOI: 10.1038/bjc.2016.118
ISSN: 0007-0920
eISSN: 1532-1827
WOS ID: 000376431200009
Scopus EID: 2-s2.0-84969219595
PMID: 27187687
Embase PUI: L610435574
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Jimenez Fonseca, Paula; Carmona-Bayonas, Alberto; Matos Garcia, Ignacio; Marcos, Rosana; Castanon, Eduardo; Antonio, Maite; Font, Carme; Biosca, Merce; Blasco, Ana; Lozano, Rebeca; Ramchandani, Avinash; Beato, Carmen; Martinez de Castro, Eva; Espinosa, Javier; Martinez-Garcia, Jeronimo; Ghanem, Ismael; Hernando Cubero, Jorge; Aragon Manrique, Isabel; Garcia Navalon, Francisco; Sevillano, Elena; Manzano, Aranzazu; Virizuela, Juan; Garrido, Marcelo; Mondejar, Rebeca; Angeles Arcusa, Maria; Bonilla, Yaiza; Perez, Quionia; Gallardo, Elena; Soriano, M. C.; Cardona, Merce; Sanchez Lasheras, Fernando; Jesus Cruz, Juan; Ayala, Francisco; Spanish Soc Med Oncology SEOM; FINITE InvestigatorsFecha de publicación
2016-05-24Tipo de documento
research articleCitación
Jimenez Fonseca P, Carmona-Bayonas A, Matos Garcia I, Marcos R, Castanon E, Antonio M, et al. A nomogram for predicting complications in patients with solid tumours and seemingly stable febrile neutropenia. Br J Cancer. 2016 May 24;114(11):1191-8. Epub 2016 May 17.Resumen
Background: We sought to develop and externally validate a nomogram and web-based calculator to individually predict the development of serious complications in seemingly stable adult patients with solid tumours and episodes of febrile neutropenia (FN). Patients and methods: The data from the FINITE study (n = 1133) and University of Salamanca Hospital (USH) FN registry (n = 296) were used to develop and validate this tool. The main eligibility criterion was the presence of apparent clinical stability, defined as events without acute organ dysfunction, abnormal vital signs, or major infections. Discriminatory ability was measured as the concordance index and stratification into risk groups. Results: The rate of infection-related complications in the FINITE and USH series was 13.4% and 18.6%, respectively. The nomogram used the following covariates: Eastern Cooperative Group (ECOG) Performance Status >= 2, chronic obstructive pulmonary disease, chronic cardiovascular disease, mucositis of grade >= 2 (National Cancer Institute Common Toxicity Criteria), monocytes <200/mm(3), and stress-induced hyperglycaemia. The nomogram predictions appeared to be well calibrated in both data sets (Hosmer-Lemeshow test, P>0.1). The concordance index was 0.855 and 0.831 in each series. Risk group stratification revealed a significant distinction in the proportion of complications. With a >= 116-point cutoff, the nomogram yielded the following prognostic indices in the USH registry validation series: 66% sensitivity, 83% specificity, 3.88 positive likelihood ratio, 48% positive predictive value, and 91% negative predictive value. Conclusions: We have developed and externally validated a nomogram and web calculator to predict serious complications that can potentially impact decision-making in patients with seemingly stable FN.
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https://dx.doi.org/10.1038/bjc.2016.118Palabras clave
Clinical Index of Stable Febrile NeutropeniaCISNE
nomogram
seemingly stable patients
risk prediction
complications
MeSH
Cardiovascular DiseasesAdult
Risk Assessment
Hyperglycemia
Pulmonary Disease, Chronic Obstructive
Humans
Febrile Neutropenia
Middle Aged
Neoplasms
Prognosis
Male
Predictive Value of Tests
Female
Nomograms
Registries
Sensitivity and Specificity
Multicenter Studies as Topic
Comorbidity
Likelihood Functions
Mucositis
DeCS
Funciones de VerosimilitudComorbilidad
Estudios Multicéntricos como Asunto
Femenino
Neutropenia Febril
Masculino
Mucositis
Nomogramas
Enfermedad Pulmonar Obstructiva Crónica
Humanos
Persona de Mediana Edad
Neoplasias
Hiperglucemia
Valor Predictivo de las Pruebas
Pronóstico
Medición de Riesgo
Enfermedades Cardiovasculares
Adulto
Sistema de Registros
Sensibilidad y Especificidad