Identificador para citar o enlazar este ítem: http://hdl.handle.net/20.500.13003/17131
Flavonoids and the Risk of Gastric Cancer: An Exploratory Case-Control Study in the MCC-Spain Study
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DOI: 10.3390/nu11050967
eISSN: 2072-6643
WOS ID: 000471021600027
Scopus EID: 2-s2.0-85065495437
PMID: 31035601
Embase PUI: L2001930355
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Vitelli Storelli, Facundo; Jose Molina, Antonio; Zamora-Ros, Raul; Fernandez-Villa, Tania; Roussou, Vasiliki; Romaguera, Dora ; Aragones, Nuria; Obon-Santacana, Mireia; Guevara, Marcela; Gomez-Acebo, Ines; Fernández-Tardón, Guillermo; Molina-Barcelo, Ana; Olmedo-Requena, Rocio; Capelo, Rocio; Chirlaque, Maria-Dolores; Perez-Gomez, Beatriz; Moreno, Victor; Castilla, Jesus; Rubin-Garcia, Maria; Pollan, Marina; Kogevinas, Manolis; Barrio Lera, Juan Pablo; Martin, VicenteFecha de publicación
2019-05Tipo de documento
research articleCitación
Vitelli Storelli F, Jose Molina A, Zamora-Ros R, Fernandez-Villa T, Roussou V, Romaguera D, et al. Flavonoids and the Risk of Gastric Cancer: An Exploratory Case-Control Study in the MCC-Spain Study. Nutrients. 2019 May;11(5):967.Resumen
Several epidemiological studies have investigated the association between the dietary flavonoid intake and gastric cancer (GC) risk; however, the results remain inconclusive. Investigating the relationship between the different classes of flavonoids and the histological types and origin of GC can be of interest to the research community. We used data from a population-based multi-case control study (MCC-Spain) obtained from 12 different regions of Spain. 2700 controls and 329 GC cases were included in this study. Odds ratios (ORs) were calculated using the mixed effects logistic regression considering quartiles of flavonoid intakes and log2. Flavonoid intake was associated with a lower GC risk (ORlog2 = 0.76; 95% CI = 0.65-0.89; ORq4vsq1 = 0.60; 95%CI = 0.40-0.89; ptrend = 0.007). Inverse and statistically significant associations were observed with anthocyanidins, chalcones, dihydroflavonols and flavan-3-ols. The isoflavanoid intake was positively associated with higher cancer risk, but without reaching a statistical significance. In general, no differences were observed in the GC risk according to the location and histological type. The flavonoid intake seems to be a protective factor against GC within the MCC-study. This effect may vary depending on the flavonoid class but not by the histological type and location of the tumor. Broader studies with larger sample size and greater geographical variability are necessary.
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https://dx.doi.org/10.3390/nu11050967Palabras clave
flavonoidsintake
gastric cancer
case-control study
MCC-Spain
MeSH
AgedCase-Control Studies
Food Analysis
Spain
Adult
Flavonoids
Humans
Middle Aged
Diet
Male
Female
Risk Factors
Odds Ratio
Stomach Neoplasms
DeCS
Neoplasias GástricasOportunidad Relativa
Femenino
Dieta
Masculino
Factores de Riesgo
Análisis de los Alimentos
Humanos
Persona de Mediana Edad
Anciano
Flavonoides
Adulto
España
Estudios de Casos y Controles