Inhibitors of hydroxymethylglutaryl-coenzyme A reductase and risk of fracture among older women
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Authors
Chan, K. ArnoldAndrade, Susan E.
Boles, Myde
Buist, Diana S. M.
Chase, Gary A.
Donahue, James G.
Goodman, Michael J.
Gurwitz, Jerry H.
LaCroix, Andrea Z.
Platt, Richard
UMass Chan Affiliations
Department of Medicine, Division of Geriatric MedicineMeyers Primary Care Institute
Document Type
Journal ArticlePublication Date
2000-07-06Keywords
Age FactorsAged
Aged, 80 and over
Bone Density
Case-Control Studies
Chronic Disease
Confidence Intervals
Confounding Factors (Epidemiology)
Female
Fractures, Bone
Hip Fractures
Humans
Humeral Fractures
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Hypolipidemic Agents
Massachusetts
Middle Aged
Odds Ratio
Osteogenesis
Patient Admission
Population Surveillance
Protective Agents
Risk Factors
Spinal Fractures
Tibial Fractures
Wrist Injuries
Health Services Research
Primary Care
Metadata
Show full item recordAbstract
BACKGROUND: Inhibitors of hydroxymethylglutaryl-coenzyme A reductase (statins) increase new bone formation in rodents and in human cells in vitro. Statin use is associated with increased bone mineral density of the femoral neck. We undertook a population-based case-control study at six health-maintenance organisations in the USA to investigate further the relation between statin use and fracture risk among older women. METHODS: We investigated women aged 60 years or older. Exposure, outcome, and confounder information was obtained from automated claims and pharmacy data from October, 1994, to September, 1997. Cases had an incident diagnosis of non-pathological fracture of the hip, humerus, distal tibia, wrist, or vertebrae between October, 1996, and September, 1997. Controls had no fracture during this period. We excluded women with records of dispensing of drugs to treat osteoporosis. FINDINGS: There were 928 cases and 2747 controls. Compared with women who had no record of statin dispensing during the previous 2 years, women with 13 or more statin dispensings during this period had a decreased risk of non-pathological fracture (odds ratio 0.48 [95% CI 0.27-0.83]) after adjustment for age, number of hospital admissions during the previous year, chronic disease score, and use of non-statin lipid-lowering drugs. No association was found between fracture risk and fewer than 13 dispensings of statins or between fracture risk and use of non-statin lipid-lowering drugs. INTERPRETATION: Statins seem to be protective against non-pathological fracture among older women. These findings are compatible with the hypothesis that statins increase bone mineral density in human beings and thereby decrease the risk of osteoporotic fractures.Source
Lancet. 2000 Jun 24;355(9222):2185-8. Link to article on publisher's siteDOI
10.1016/S0140-6736(00)02400-4Permanent Link to this Item
http://hdl.handle.net/20.500.14038/36874PubMed ID
10881890Related Resources
Link to Article in PubMedae974a485f413a2113503eed53cd6c53
10.1016/S0140-6736(00)02400-4
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