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Fluid models and simulations of biological cell phenomenaThe dynamics of coated droplets are examined within the context of biofluids. Of specific interest is the manner in which the shape of a droplet, the motion within it as well as that of aggregates of droplets can be controlled by the modulation of surface properties and the extent to which such fluid phenomena are an intrinsic part of cellular processes. From the standpoint of biology, an objective is to elucidate some of the general dynamical features that affect the disposition of an entire cell, cell colonies and tissues. Conventionally averaged field variables of continuum mechanics are used to describe the overall global effects which result from the myriad of small scale molecular interactions. An attempt is made to establish cause and effect relationships from correct dynamical laws of motion rather than by what may have been unnecessary invocation of metabolic or life processes. Several topics are discussed where there are strong analogies droplets and cells including: encapsulated droplets/cell membranes; droplet shape/cell shape; adhesion and spread of a droplet/cell motility and adhesion; and oams and multiphase flows/cell aggregates and tissues. Evidence is presented to show that certain concepts of continuum theory such as suface tension, surface free energy, contact angle, bending moments, etc. are relevant and applicable to the study of cell biology.
Document ID
19820015584
Acquisition Source
Legacy CDMS
Document Type
Conference Paper
Authors
Greenspan, H. P.
(Massachusetts Inst. of Tech. Cambridge, MA, United States)
Date Acquired
August 10, 2013
Publication Date
March 1, 1982
Publication Information
Publication: JPL Proc. of the 2d Intern. Colloq. on Drops and Bubbles
Subject Category
Fluid Mechanics And Heat Transfer
Accession Number
82N23458
Distribution Limits
Public
Copyright
Work of the US Gov. Public Use Permitted.
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