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Suspension cell culture in microgravity and development of a space bioreactorNASA has methodically developed unique suspension type cell and recovery apparatus culture systems for bioprocess technology experiments and production of biological products in microgravity. The first space bioreactor has been designed for microprocessor control, no gaseous headspace, circulation and resupply of culture medium, and slow mixing in very low shear regimes. Various ground based bioreactors are being used to test reactor vessel design, on-line sensors, effects of shear, nutrient supply, and waste removal from continuous culture of human cells attached to microcarriers. The small (500 ml) bioreactor is being constructed for flight experiments in the Shuttle middeck to verify systems operation under microgravity conditions and to measure the efficiencies of mass transport, gas transfer, oxygen consumption, and control of low shear stress on cells.
Document ID
19880007785
Acquisition Source
Legacy CDMS
Document Type
Conference Paper
Authors
Morrison, Dennis R. (NASA Lyndon B. Johnson Space Center Houston, TX, United States)
Date Acquired
September 5, 2013
Publication Date
December 1, 1987
Publication Information
Publication: Space Bioreactor Science Workshop
Subject Category
Life Sciences (General)
Accession Number
88N17169
Distribution Limits
Public
Copyright
Work of the US Gov. Public Use Permitted.

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