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Fed-batch control based upon the measurement of intracellular NADHA series of experiments demonstrating that on-line measurements of intracellular NADH by culture fluorescence can be used to monitor and control the fermentation process are described. A distinct advantage of intercellular NADH measurements over other monitoring techniques such as pH and dissolved oxygen is that it directly measures real time events occurring within the cell rather than changes in the environment. When coupled with other measurement parameters, it can provide a finer degree of sophistication in process control.
Document ID
19880007791
Acquisition Source
Legacy CDMS
Document Type
Conference Paper
Authors
Armiger, W. B. (BioChem Technology, Inc. Malvern, PA, United States)
Lee, J. F. (BioChem Technology, Inc. Malvern, PA, United States)
Montalvo, L. M. (BioChem Technology, Inc. Malvern, PA, United States)
Forro, J. R. (BioChem Technology, Inc. Malvern, PA, United States)
Date Acquired
September 5, 2013
Publication Date
December 1, 1987
Publication Information
Publication: NASA. Lyndon B. Johnson Space Center, Space Bioreactor Science Workshop
Subject Category
Life Sciences (General)
Accession Number
88N17175
Distribution Limits
Public
Copyright
Work of the US Gov. Public Use Permitted.

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