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Renal function alterations during skeletal muscle disuse in simulated microgravityThis project was to examine the alterations in renal functions during skeletal muscle disuse in simulated microgravity. Although this area could cover a wide range of investigative efforts, the limited funding resulted in the selection of two projects. These projects would result in data contributing to an area of research deemed high priority by NASA and would address issues of the alterations in renal response to vasoactive stimuli during conditions of skeletal muscle disuse as well as investigate the contribution of skeletal muscle disuse, conditions normally found in long term human exposure to microgravity, to the balance of fluid and macromolecules within the vasculature versus the interstitium. These two projects selected are as follows: investigate the role of angiotensin 2 on renal function during periods of simulated microgravity and skeletal muscle disuse to determine if the renal response is altered to changes in circulating concentrations of angiotensin 2 compared to appropriate controls; and determine if the shift of fluid balance from vasculature to the interstitium, the two components of extracellular fluid volume, that occur during prolonged exposure to microgravity and skeletal muscle disuse is a result, in part, to alterations in the fluid and macromolecular balance in the peripheral capillary beds, of which the skeletal muscle contains the majority of recruitment capillaries. A recruitment capillary bed would be most sensitive to alterations in Starling forces and fluid and macromolecular permeability.
Document ID
19940009351
Acquisition Source
Legacy CDMS
Document Type
Contractor Report (CR)
Authors
Tucker, Bryan J. (California Univ. San Diego, CA, United States)
Date Acquired
September 6, 2013
Publication Date
October 31, 1992
Subject Category
Aerospace Medicine
Report/Patent Number
NAS 1.26:194258
NASA-CR-194258
Accession Number
94N13824
Funding Number(s)
CONTRACT_GRANT: NCC2-556
Distribution Limits
Public
Copyright
Work of the US Gov. Public Use Permitted.

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