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Characterization of surfacesLow gravity biotechnology experiments indicate a need to better understand and control a host of liquid-solid interfacial phenomena which reduce the efficiency of bioseparations methods on earth as well as in space. We have improved and utilized polymeric and silane derivatives, developed in association with MSFC, in order to control such phenomena. The objectives of the proposed research have been obtained. They were to improve NASA-patented coatings capable of controlling macromolecular adsorption, electroosmosis, and particle electrophoresis over a wide range of pH, and to further characterize the ability of polymeric coatings to control wall wetting interactions. To date this research has resulted in six publications and four abstracts. It has also aided researchers at MSFC with studies on the electrophoresis of large DNA molecules in free solution. It will continue to enhance NASA's efforts to exploit the space environment to enhance knowledge of phenomena relevant to biotechnology, and obtain bioseparations currently unobtainable on Earth. Abstracts from the 1994 ACS Meeting in Birmingham are attached.
Document ID
19950009650
Acquisition Source
Legacy CDMS
Document Type
Contractor Report (CR)
Authors
Vanalstine, James M. (Alabama Univ. Huntsville, AL, United States)
Date Acquired
September 6, 2013
Publication Date
September 15, 1992
Subject Category
Materials Processing
Report/Patent Number
NAS 1.26:196995
NASA-CR-196995
Accession Number
95N16065
Funding Number(s)
CONTRACT_GRANT: NAG8-955
Distribution Limits
Public
Copyright
Work of the US Gov. Public Use Permitted.

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