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Growth of Streptomyces Hygroscopicus in Rotating-Wall Bioreactor Under Simulated Microgravity Inhibits Rapamycin ProductionGrowth of Streptomyces hygroscopicus under conditions of simulated microgravity in a rotating-wall bioreactor resulted in a pellet form of growth, lowered dry cell weight, and inhibition of rapamycin production. With the addition of Teflon beads to the bioreactor, growth became much less pelleted, dry cell weight increased but rapamycin production was still markedly inhibited. Growth under simulated microgravity favored extracellular production of rapamycin in contrast to a greater percentage of cell-bound rapamycin observed under normal gravity conditions.
Document ID
20000084156
Acquisition Source
Johnson Space Center
Document Type
Preprint (Draft being sent to journal)
Authors
Fang, A.
(Massachusetts Inst. of Tech. Cambridge, MA United States)
Pierson, D. L.
(NASA Johnson Space Center Houston, TX United States)
Mishra, S. K.
(Universities Space Research Association Houston, TX United States)
Demain, A. L.
(Massachusetts Inst. of Tech. Cambridge, MA United States)
Date Acquired
September 7, 2013
Publication Date
January 1, 2000
Subject Category
Life Sciences (General)
Funding Number(s)
CONTRACT_GRANT: NAG9-602
Distribution Limits
Public
Copyright
Work of the US Gov. Public Use Permitted.
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