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Microvascular Branching as a Determinant of Blood Flow by Intravital Particle Imaging VelocimetryThe effects of microvascular branching on blood flow were investigated in vivo by microscopic particle imaging velocimetry (micro-PIV). We use micro-PIV to measure blood flow by tracking red blood cells (RBC) as the moving particles. Velocity flow fields, including flow pulsatility, were analyzed for the first four branching orders of capillaries, postcapillary venules and small veins of the microvascular network within the developing avian yolksac at embryonic day 5 (E5). Increasing volumetric flowrates were obtained from parabolic laminar flow profiles as a function of increasing vessel diameter and branching order. Maximum flow velocities increased approximately twenty-fold as the function of increasing vessel diameter and branching order compared to flow velocities of 100 - 150 micron/sec in the capillaries. Results from our study will be useful for the increased understanding of blood flow within anastomotic, heterogeneous microvascular networks.
Document ID
20070022365
Acquisition Source
Glenn Research Center
Document Type
Conference Paper
Authors
Parsons-Wingerter, Patricia
(NASA Glenn Research Center Cleveland, OH, United States)
McKay, Terri L.
(NASA Glenn Research Center Cleveland, OH, United States)
Vickerman, Mary B.
(NASA Glenn Research Center Cleveland, OH, United States)
Wernet, Mark P.
(NASA Glenn Research Center Cleveland, OH, United States)
Myers, Jerry G.
(NASA Glenn Research Center Cleveland, OH, United States)
Radhakrishnan, Krishnan
(New Mexico Univ. Albuquerque, NM, United States)
Date Acquired
August 23, 2013
Publication Date
April 28, 2007
Subject Category
Life Sciences (General)
Meeting Information
Meeting: Microcirculatory Society 54th Annual Meeting
Location: Washington, DC
Country: United States
Start Date: April 28, 2007
End Date: May 2, 2007
Sponsors: The Microcirculatory Society
Funding Number(s)
WBS: WBS 667266.01.03.0543.01
Distribution Limits
Public
Copyright
Public Use Permitted.
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