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Use of fibroblast growth factor 2 for expansion of chondrocytes and tissue engineeringThe present invention provides an improved method for expanding cells for use in tissue engineering. In particular the method provides specific biochemical factors to supplement cell culture medium during the expansion process in order to reproduce events occurring during embryonic development with the goal of regenerating tissue equivalents that resemble natural tissues both structurally and functionally. These specific biochemical factors improve proliferation of the cells and are capable of de-differentiation mature cells isolated from tissue so that the differentiation potential of the cells is preserved. The bioactive molecules also maintain the responsiveness of the cells to other bioactive molecules. Specifically, the invention provides methods for expanding chondrocytes in the presence of fibroblast growth factor 2 for use in regeneration of cartilage tissue.
Document ID
20080006018
Acquisition Source
Johnson Space Center
Document Type
Other - Patent
Authors
Martin, Ivan
Freed, Lisa E.
Langer, Robert
Vunjak-Novakovic, Gordana
Date Acquired
August 24, 2013
Publication Date
June 24, 2003
Subject Category
Life Sciences (General)
Funding Number(s)
CONTRACT_GRANT: NAG9-836
Distribution Limits
Public
Copyright
Work of the US Gov. Public Use Permitted.
Patent
US-PATENT-6,582,960
Patent Application
US-PATENT-APPL-SN-397417
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