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Distribution of Chromosome Breakpoints in Human Epithelial Cells Exposed to Low- and High-LET RadiationLow-and high-LET radiations produced distinct breakpoint distributions. The difference of the breakpoint distributions between low-and high-LET only appeared in break ends involved in interchromosome exchanges. The breakpoint distributions for break ends participating in intrachromosome exchanges were similar. Gene-rich regions do not necessarily have more chromosome breaks. High-LET appeared to produce long live (data not shown) or longer live breaks that can migrate a longer distance before rejoining with other breaks. Domains occupied by different segments of the chromosomes may be responsible for the breakpoint distribution. The dose responses for interchromosomal exchanges were linear in all four exposures. However, the dose response for intrachromosomal exchanges were none linear. Increasing dose of high dose rate exposure (Fe-ions or -rays) increase the fraction of cells with intrachromosome aberrations, whereas increasing dose of low dose rate exposure (neutrons or -rays) does not affect the fraction of cells with intrachromosome aberrations.
Document ID
20100026034
Acquisition Source
Johnson Space Center
Document Type
Conference Paper
Authors
Hada, Megumi
(NASA Johnson Space Center Houston, TX, United States)
Zhang, Ye
(NASA Johnson Space Center Houston, TX, United States)
Cucinotta, Francis A.
(NASA Johnson Space Center Houston, TX, United States)
Feiveson, Alan
(NASA Johnson Space Center Houston, TX, United States)
Wu, Honglu
(NASA Johnson Space Center Houston, TX, United States)
Date Acquired
August 24, 2013
Publication Date
July 18, 2010
Subject Category
Life Sciences (General)
Report/Patent Number
JSC-CN-21126
Meeting Information
Meeting: COSPAR
Location: Bremen
Country: Germany
Start Date: July 18, 2010
End Date: July 25, 2010
Sponsors: Committee on Space Research
Distribution Limits
Public
Copyright
Work of the US Gov. Public Use Permitted.
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