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Method for using magnetic particles in droplet microfluidicsMethods of utilizing magnetic particles or beads (MBs) in droplet-based (or digital) microfluidics are disclosed. The methods may be used in enrichment or separation processes. A first method employs the droplet meniscus to assist in the magnetic collection and positioning of MBs during droplet microfluidic operations. The sweeping movement of the meniscus lifts the MBs off the solid surface and frees them from various surface forces acting on the MBs. A second method uses chemical additives to reduce the adhesion of MBs to surfaces. Both methods allow the MBs on a solid surface to be effectively moved by magnetic force. Droplets may be driven by various methods or techniques including, for example, electrowetting, electrostatic, electromechanical, electrophoretic, dielectrophoretic, electroosmotic, thermocapillary, surface acoustic, and pressure.
Document ID
20120001627
Acquisition Source
Ames Research Center
Document Type
Other - Patent
Authors
Shah, Gaurav Jitendra
Kim, Chang-Jin
Date Acquired
August 25, 2013
Publication Date
January 10, 2012
Subject Category
Fluid Mechanics And Thermodynamics
Funding Number(s)
CONTRACT_GRANT: NCC2-1364
Distribution Limits
Public
Copyright
Work of the US Gov. Public Use Permitted.
Patent
US-Patent-8,093,064
Patent Application
US-Patent-Appl-SN-12/465,935

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