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Improved Cell Culture Method for Growing Contracting Skeletal Muscle ModelsAn improved method for culturing immature muscle cells (myoblasts) into a mature skeletal muscle overcomes some of the notable limitations of prior culture methods. The development of the method is a major advance in tissue engineering in that, for the first time, a cell-based model spontaneously fuses and differentiates into masses of highly aligned, contracting myotubes. This method enables (1) the construction of improved two-dimensional (monolayer) skeletal muscle test beds; (2) development of contracting three-dimensional tissue models; and (3) improved transplantable tissues for biomedical and regenerative medicine applications. With adaptation, this method also offers potential application for production of other tissue types (i.e., bone and cardiac) from corresponding precursor cells.
Document ID
20130011232
Acquisition Source
Johnson Space Center
Document Type
Other - NASA Tech Brief
Authors
Marquette, Michele L.
(Texas Univ. Medical Branch Houston, TX, United States)
Sognier, Marguerite A.
(Universities Space Research Association Houston, TX, United States)
Date Acquired
August 27, 2013
Publication Date
March 1, 2013
Publication Information
Publication: NASA Tech Briefs, March 2013
Subject Category
Life Sciences (General)
Report/Patent Number
MSC-24314-1
Distribution Limits
Public
Copyright
Public Use Permitted.
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