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NASA Bioculture System: From Experiment Definition to Flight PayloadStarting in 2015, the NASA Bioculture System will be available to the science community to conduct cell biology and microbiology experiments on ISS. The Bioculture System carries ten environmentally independent Cassettes, which house the experiments. The closed loop fluids flow path subsystem in each Cassette provides a perfusion-based method for maintain specimen cultures in a shear-free environment by using a biochamber based on porous hollow fiber bioreactor technology. Each Cassette contains an incubator and separate insulated refrigerator compartment for storage of media, samples, nutrients and additives. The hardware is capable of fully automated or manual specimen culturing and processing, including in-flight experiment initiation, sampling and fixation, up to BSL-2 specimen culturing, and the ability to up to 10 independent cultures in parallel for statistical analysis. The incubation and culturing of specimens in the Bioculture System is a departure from standard laboratory culturing methods. Therefore, it is critical that the PI has an understanding the pre-flight test required for successfully using the Bioculture System to conduct an on-orbit experiment. Overall, the PI will conduct a series of ground tests to define flight experiment and on-orbit implementation requirements, verify biocompatibility, and determine base bioreactor conditions. The ground test processes for the utilization of the Bioculture System, from experiment selection to flight, will be reviewed. Also, pre-flight test schedules and use of COTS ground test equipment (CellMax and FiberCell systems) and the Bioculture System will be discussed.
Document ID
20150000190
Acquisition Source
Ames Research Center
Document Type
Conference Paper
Authors
Sato, Kevin Y. (Lockheed Martin Space Operations Moffett Field, CA, United States)
Almeida, Eduardo (NASA Ames Research Center Moffett Field, CA United States)
Austin, Edward M. (NASA Ames Research Center Moffett Field, CA United States)
Date Acquired
January 6, 2015
Publication Date
October 22, 2014
Subject Category
Life Sciences (General)
Report/Patent Number
ARC-E-DAA-TN16080
Meeting Information
Meeting: Annual Meeting of the American Society for Gravitational And Space Research
Location: Pasadena, CA
Country: United States
Start Date: October 22, 2014
End Date: October 26, 2014
Sponsors: American Society for Gravitational and Space Research
Funding Number(s)
CONTRACT_GRANT: NAS2-02090
Distribution Limits
Public
Copyright
Public Use Permitted.
Keywords
Bioculture System
ASGSB

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