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So You Want to Go to Mars: Bones and Matters of the HeartThere is evidence that weightlessness and radiation, two elements of the spaceflight environment, can lead to detrimental changes in human musculoskeletal tissue, including bone loss and muscle atrophy. This bone loss is thought to be brought about by the increased activity of bone-resorbing osteoclasts and functional changes in bone-forming osteoblasts, cells that give rise to mature osteocytes. Collectively, our research team aims to understand the molecular mechanisms underlying the responses of mammalian tissue to the spaceflight environment using earth-based animal and cellular models. The overarching goal is to identify molecular targets to prevent tissue decrements induced by spaceflight and earth-based scenarios of radiotherapy, accidental radiation exposure and reduced mobility. In this talk, I will provide an overview of skeletal and cardiovascular responses to spaceflight and will highlight our research progress on understanding the role of reactive oxygen species (ROS) signaling in skeletal responses to radiation and simulated weightlessness.
Document ID
20180001567
Acquisition Source
Ames Research Center
Document Type
Presentation
Authors
Tahimic, Candice (Wyle Labs., Inc. Moffett Field, CA, United States)
Globus, Ruth (NASA Ames Research Center Moffett Field, CA, United States)
Torres, Samantha (Blue Marble Space Seattle, WA, United States)
Steczina, Sonette (Blue Marble Space Seattle, WA, United States)
Date Acquired
March 2, 2018
Publication Date
March 8, 2017
Subject Category
Aerospace Medicine
Life Sciences (General)
Report/Patent Number
ARC-E-DAA-TN39947
Meeting Information
Meeting: Biology Graduate Seminar Series
Location: San Jose, CA
Country: United States
Start Date: March 8, 2017
Sponsors: San Jose State Univ.
Funding Number(s)
CONTRACT_GRANT: NNA14AB82C
CONTRACT_GRANT: NNX15AG98A
Distribution Limits
Public
Copyright
Public Use Permitted.
Keywords
heart
bone
radiation
simulated weightlessness

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