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Effect of N-acetyl-cysteine and hyperoxia on erythropoietin production

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Momeni, Mona [UCL] De Kock, Marc [UCL] Devuyst, Olivier [UCL] Liistro, Giuseppe [UCL]

Previous studies in healthy subjects have shown an increase in erythropoietin (EPO) production after administration of N-acetyl-cysteine (NAC). These authors hypothesized that NAC increases intracellular reduced glutathione, decreasing reactive oxygen species and enabling EPO production. We investigated if EPO production could be stimulated with a single dose of NAC, after 90 min of pure oxygen breathing. Thirty-eight healthy volunteers were randomized into either the control (C) group or the NAC group, which received 600 mg NAC PO dissolved in a glass of orange juice, 60 min before breathing 15 L/min of 100% normobaric oxygen. Orange juice was administered to both groups. Blood samples for EPO measurement were taken at T0, before the orange juice administration, and T1, T2, T3 and T4, respectively, 8, 24, 32 and 48 h after the orange juice. The EPO concentrations of the NAC group decreased significantly at T1, followed by a significant increase compared to baseline, which was obvious until T4. The EPO concentrations of the C group did not show any significant variations. In this study, a significant increase of EPO production was observed after a short-term hyperoxic stimulus only when preceded with the administration of a single dose of NAC.

Document type Article de périodique (Journal article) – Article de recherche – Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't
Access type Accès restreint
Publication date 2011
Language Anglais
Journal information "European Journal of Applied Physiology" - Vol. 111, no. 11, p. 2681-2686 (2011)
Peer reviewed yes
Publisher Springer ((Germany) Heidelberg)
issn 1439-6319
e-issn 1439-6327
Publication status Publié
Affiliations UCL - SSS/IONS/CEMO - Pôle Cellulaire et moléculaire
UCL - SSS/IONS - Institute of NeuroScience
UCL - SSS/IREC/NEFR - Pôle de Néphrologie
UCL - SSS/IREC/LUNS - Pôle pneumologie, ORL (airways) et dermatologie (skin)
UCL - (SLuc) Service de pneumologie
UCL - (SLuc) Service de néphrologie
UCL - (SLuc) Service d'anesthésiologie
MESH Subject Acetylcysteine - pharmacology ; Adult ; Oxygen Consumption - physiology ; Respiratory Function Tests ; Time Factors ; Young Adult ; Erythropoietin - biosynthesis, blood ; Exercise Test ; Female ; Humans ; Hyperoxia - blood, metabolism ; Male ; Middle Aged ; Oxygen - metabolism
Links
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Bibliographic reference Momeni, Mona ; De Kock, Marc ; Devuyst, Olivier ; Liistro, Giuseppe. Effect of N-acetyl-cysteine and hyperoxia on erythropoietin production. In: European Journal of Applied Physiology, Vol. 111, no. 11, p. 2681-2686 (2011)
Permanent URL http://hdl.handle.net/2078.1/107375