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Quality of life after orthotopic liver transplantation in children. An overview of physical, psychological and social outcome.

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Sokal, Etienne [UCL]

Orthotopic liver transplantation is now routinely performed as a cure of numerous untreatable paediatric liver diseases. Evaluation of post-transplant quality of life is subjective and very difficult. It has to take into account the pre-transplant quality of life and the emotional stress to the family. Transplantation saves life in 65%-90% of the patients. Several diseases may, however, recur after transplantation, such as hepatitis B, C or NANB, or tumours. Some metabolic diseases may also progress in other organs. Extra-hepatic manifestations or sequelae may persist after transplantation. Complications of transplantation include renal function impairment, hypertension, viral and opportunistic diseases. Of particular concern is the post-transplant lymphoproliferative syndrome. Liver transplantation is able to restore growth. Children are less frequently admitted to hospital after transplantation, take fewer medications, return to school, are less dependent and interact more normally with their peers. Quality of life may not reach perfection, and depends also on the way our society accepts these imperfections.

Document type Article de périodique (Journal article) – Journal Article, Review
Access type Accès restreint
Publication date 1995
Journal information "European journal of pediatrics" - Vol. 154, no. 3, p. 171-5 (1995)
Peer reviewed yes
issn 0340-6199
Affiliation UCL - MD/GYPE - Département de gynécologie, d'obstétrique et de pédiatrie
MESH Subject Child ; Humans ; Immunosuppression - adverse effects ; Liver Transplantation - adverse effects - mortality - psychology ; Quality of Life ; Recurrence ; Social Adjustment
Links
  1. A-Kader HH, Ryckman FC, Balistreri WF (1991) Liver transplantation in the pediatric population: indications and monitoring. Clin Transplant 5: 161–167
  2. Busuttil RW, Seu P, Millis JM, OIthoff KM, Hiatt JR, Milewicz A, Nuesse B, Khoury G el Raybould D, Nyerges A, et al (1991) Liver transplantation in children. Ann Surg 213: 48–57
  3. Cames B, Rahier J, Burtomboy G, Ville de Goyet J de, Reding R, Lamy M, Otte JB, Sokal EM (1992) Acute adenovirus hepatitis in liver transplant recipients. J Pediatr 120: 33–37
  4. Cilio MR, Danhaive O, Gadisceux JF, Otte JB, Sokal EM (1993) Unusual cyclosporin related neurological complications in recipients of liver transplants. Arch Dis Child 68: 405–407
  5. Cockburn I, Krupp P, Monka C (1989) Present experience of Sandimmun in pregnancy. Transplant Proc 21: 3730–3732
  6. Codoner-Franch P, Bernard O, Alvarez F (1994) Long term follow up growth in height after successful liver transplantation. J Pediatr 124 (in press)
  7. Danhaive O, Ninane J, Sokal EM, Latinne D, Philippe M, Gosseye S, Clapuyt P, Otte JB (1992) Hepatic localization of a fibrosarcoma in a child with a liver transplant. J Pediatr 120: 434–437
  8. DeVictor D, Desplanques L, Debray D, Ozier Y, Dubousset AM, Valayer J, Houssin D, Bernard O, Huault G (1992) Emergency liver transplantation for fulminant liver failure in infants and children. Hepatology 16: 1156–1162
  9. Dussaix E, Paillette L de, Laurent-Puig P, Martres P, Lykavieris P, Bernard O, Alvarez F (1993) Hepatitis C virus infection in pediatric liver transplantation. Transplantation 55: 795–798
  10. Fagot-Largeault A (1989) Les causes de la mort. Histoire naturelle et facteurs de risque. Paris, Vrin
  11. Gartner JC, Zitelli BJ, Malatack J, Shaw BW, Iwatsuki S, Starzl TE (1987) Orthotopic liver transplantation in childre: two year experience with 47 patients. Pediatrics 74: 140–145
  12. Hughes WT, Rivera GK, Schell MJ, Thornton D, Lott L (1987) Successful intermitent chemoprophylaxis for pneumocystis carinii pneumonitis. N Engl J Med 316: 1627–1632
  13. Lantos JD (1993) Ethical assesment of innovative therapies: liver transplantation using living donors. In: Karen G (ed) Textbook of ethics in pediatric research. Krieger Publ Co, Malabar, Florida, pp 137–146
  14. Laskin OL, Cederberg DM, Mills J, Eron LJ, Mildvan D, Spector S (1993) Ganciclovir for the treatment and suppression of serious infections caused by cytomegalovirus. Am J Med 83: 201–207
  15. Lawless S, Ellis D, Thompson A, Cook DR, Esquivel C, Starzl T (1989) Mechanisms of hypertension during and after orthotopic liver transplantation in children. J Pediatr 115: 372–379
  16. Malatack J. Jeffrey, Gartner J. Carlton, Urbach Andrew H., Zitelli Basil J., Orthotopic liver transplantation, Epstein-Barr virus, cyclosporine, and lymphoproliferative disease: A growing concern, 10.1016/s0022-3476(05)80024-1
  17. Martin P., Friedman L.S., Recurrent Hepatitis B in liver transplant recipients—No easy answers, 10.1016/0016-5085(91)90747-9
  18. Martin P, Munoz SJ, Di Bisceglie AM, Rubin R, Waggoner JC, Armenti VT, Moritz MJ, Jarrell BE, Maddrey WC (1991) Recurrence of hepatitis C virus infection after orthotopic liver transplantation. Hepatology 13: 719–721
  19. McDiarmid S, Ettenger RB, Fine RN, Busuttil RW (1989) Serial decrease in glomerular filtration rate in long term pediatric liver transplantation survivors treated with Cyclosporine A. Transplantation 47: 314–318
  20. Muller R, Gubernatis G, Farle M, Niehoff G, Klein H, Wittekind C, Tusch G, Lautz HU, Boker K, Stangel W, et al (1991) Liver transplantation in HBs antigen (HBsAg) carriers. Prevention of hepatitis B virus (HBV) recurrence by passive immunization. J Hepatol 13: 90–96
  21. O'Grady JG, Polson RJ, Rolles K, Calne RY, Williams R (1988) Liver transplantation for malignant disease. Ann Surg 207: 373–379
  22. Ohtomo Y, Fukuda Y, Yabuta K, Miyano T, Tomino Y, Shirai T (1992) Glomerular alterations in children with biliary atresia. J Pediatr 120: 404–408
  23. Otte JB (1991) Recent developments in liver transplantation. J Hepatol 12: 386–393
  24. Otte JB, Ville de Goyet J de, Reding R, et al (1993) Liver transplantation in children. In: Buts JP, Sokal EM (eds) Management of digestive and liver disorders in infants and children. Elsevier, Amsterdam, pp 669–677
  25. Penn I, Burton ME (1988) Cancers after cyclosporine therapy. Transplant Proc 20: 885–892
  26. Pereira BJG, Milford EL, Kirkman RL, Quan S, Sayre KP, Johnson PJ, Wilber JC, Levey AS (1992) Prevalence of hepatitis C virus RNA in organ donors positive for hepatitis C antibody and in the recipients of their organs. N Engl J Med 327: 910–915
  27. Rakela Jorge, Hepatitis C viral infection in liver transplant patients: How bad is it really?, 10.1016/0016-5085(92)91134-p
  28. Ringe B, Wittekind C, Bechstein WO, Buzendhal H, Pichlmayr R (1989) The role of liver transplantation in hepatobiliary malignancy. A retrospective analysis of 95 patients with particular regard to tumor stage and recurrence. Ann Surg 209: 88–98
  29. Rizzetto M, Recchia S, Salizzoni M (1991) Liver transplantation in carriers of the HBsAg. J Hepatol 13: 5–7
  30. Schwartz George J., Brion Luc P., Spitzer Adrian, The Use of Plasma Creatinine Concentration for Estimating Glomerular Filtration Rate in Infants, Children, and Adolescents, 10.1016/s0031-3955(16)36251-4
  31. Shah Gunjan, Demetris A.Jake, Gavaler Judith S., Lewis Jessica H., Todo Saturo, Starzl Thomas E., Van Thiel David H., Incidence, prevalence, and clinical course of hepatitis C following liver transplantation, 10.1016/0016-5085(92)91130-v
  32. Sokal EM, Veyckemans, F, Ville de Goyet J de, Moulin D, Van Hoorebeeck N, Alberti D, Buts JP, Rahier J, Van Obbergh L, Clapuyt P, Carlier M, Claus D, Latinne D, Hemptinne B de, Otte JB (1990) Liver transplantation in children less than one year of age. J Pediatr 117: 205–210
  33. Sokal EM, Ulla L, Otte JB (1992) Hepatitis B vaccine response before and after transplantation in 55 extrahepatic biliary atresia children. Dig Dis Sc 37: 1250–1252
  34. Sokal EM, Alberti D, Van Hoof F, Ville de Goyet J de, Barsy T de, Otte JB (1992) Progressive cardiac failure following orthotopic liver transplantation for type IV glycogenosis. Eur J Pediatr 151: 200–203
  35. Sokal EM, Bustos R, Van Hoof F, Otte JB (1993) Liver transplantation for hereditary tyrosinemia. Early transplantation following patient's stabilization. Transplantation 54: 937–939
  36. Sokal EM, Cariagozoglou T, Lamy M, Reding R, Otte JB (1993) Epstein Barr virus serology and EBV associated lymphoproliferative disorders in pediatric liver transplant recipients. Transplantation 56: 1394–1398
  37. Sokal EM, Kodsi S, Otte JB, Maes M (1993) Croissance après transplantation hepatique pour atrésie des voies biliaires, Suivi à trois ans. (abstract) Arch Fr Pédiatr
  38. Sokal EM, Ulla L, Harvengt C, Otte JB (1993) Liver transplantation for homozygous familial hypercholesterolemia before onset of cardiovascular complications. Transplantation 55: 432–433
  39. Spolidero JV, Berquist WE, Pehlivanoglu E, Busuttil R, Saluski I, Vargas J, Ament ME (1988) Growth acceleration in children after orthotopic liver transplantation. J Pediatr 112: 41–44
  40. Stewart SM, Uauy R, Waller DA, Kennard BD, Benser M, Andrews WS (1989) Mental and motor development, social competence and growth one year after succesful pediatric liver transplantation. J Pediatr 114: 574–581
  41. Van Dop C, Jabs KL, Donohue A, Bock GH, Fivush BA, Harmon WE (1992) Accelerated growth rates in children treated with growth hormone after renal transplantation. J Pediatr 120: 244–250
  42. Whitington PF, Emond JC, Black DD, Whitington SH, Boone P, Smith C, Thistlethwaite JR, Broelsch CE (1991) Indications for liver transplantation in pediatric patients. Clin Transplant 5: 155–160
  43. Zitelli BJ, Miller JW, Gartner JC, Malatack JJ, Urbach AH, Belle SH, Williams L, Kirkpatrick B, Starzl TE (1988) Changes in life-style after liver transplantation. Pediatrics 82: 173–180
Bibliographic reference Sokal, Etienne. Quality of life after orthotopic liver transplantation in children. An overview of physical, psychological and social outcome.. In: European journal of pediatrics, Vol. 154, no. 3, p. 171-5 (1995)
Permanent URL http://hdl.handle.net/2078.1/11916