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Slow increase of homovanillic acid in cerebrospinal fluid after levodopa administration.

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Raftopoulos, Christian [UCL] Dethy, S Laute , M A Goldman , S Naini, A B Hildebrand, J

Concentrations of major catabolites of dopamine were followed in the ventricular cerebrospinal fluid (CSF) in five patients undergoing intracranial pressure monitoring for chronic hydrocephalus. Determinations were made every 2 h following the administration of carbidopa/levodopa 25/250 mg (one Sinemet capsule) given 8 h apart. The rise of homovanillic acid (HVA) concentrations was slow and progressive, reaching the level of statistical significance (p < or = 0.01) only 8 h after the second administration of Sinemet. The rise in 3,4-dihydroxyphenylacetic acid (DOPAC) was faster than the rise in HVA, with the peak value detected 4 h after the first administration of Sinemet. These data are interpreted as a confirmation, in humans, of a slow pool of exogenous levodopa, previously demonstrated in animal studies.

Document type Article de périodique (Journal article) – Article de recherche
Access type Accès restreint
Publication date 1996
Language Anglais
Journal information "Movement Disorders" - Vol. 11, no.1, p. 59-62 (1996)
Peer reviewed yes
Publisher JohnWiley & Sons, Inc. ((United States) Hoboken)
issn 0885-3185
e-issn 1531-8257
Affiliations UCL - (SLuc) Service de neurochirurgie
UCL - MD/CHIR - Département de chirurgie
MESH Subject 3,4-Dihydroxyphenylacetic Acid ; Hydrocephalus ; Levodopa ; Male ; Middle Aged ; Aged ; Antiparkinson Agents ; Carbidopa ; Drug Administration Schedule ; Drug Combinations ; Female ; Homovanillic Acid ; Humans
Links
  1. Olanow, Ann Neurol, 29, 556 (1991)
  2. Moussa, Ann Neurol, 31, 113 (1992)
  3. Duret, Acta Neurol Scan, 80, 64 (1989)
  4. Monoamine metabolites and neuropeptides in patients with Parkinson's disease, Huntington's chorea, Shy-Drager syndrome, and torsion dystonia. In: eds. Advances in neurology, vol. 53. New York: Raven Press, 1990: 117-122.
  5. Hildebrand, Acta Neurol Scand, 81, 427 (1990)
  6. Przedborski, Mov Disord, 10, 28 (1995)
  7. LeWitt P. A., Galloway M. P., Matson W., Milbury P., McDermott M., Srivastava D. K., Oakes D., , Markers of dopamine metabolism in Parkinson's disease, 10.1212/wnl.42.11.2111
  8. Neurochemical markers of Parkinson's disease. In: eds. Therapy of Parkinson's disease. New York: Marcel Dekker, 1990; 63-93.
  9. Effect of pergolide on endogenous and exogenous l-dopa metabolism in the rat striatum: a microdialysis study. J Neurol Transm Gen Sect (in press).
  10. Melega, Biochem Pharmacol, 39, 1853 (1990)
  11. Pauwels, Eur J Pharmacol, 257, 53 (1994)
  12. Hammerstad, Ann Neurol, 34, 603 (1993)
  13. Hammerstad, Ann Neurol, 27, 495 (1990)
  14. Westerink B.H.C., Justice J.B., Microdialysis compared with other in vivo release models, Microdialysis in the Neurosciences (1991) ISBN:9780444811943 p.23-43, 10.1016/b978-0-444-81194-3.50007-1
  15. Touchet, Neuropharmacology, 28, 1217 (1989)
Bibliographic reference Raftopoulos, Christian ; Dethy, S ; Laute , M A ; Goldman , S ; Naini, A B ; et. al. Slow increase of homovanillic acid in cerebrospinal fluid after levodopa administration.. In: Movement Disorders, Vol. 11, no.1, p. 59-62 (1996)
Permanent URL http://hdl.handle.net/2078.1/123391