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CD66a (CEACAM1) expression by mouse natural killer cells.

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Thirion, Gaëtan [UCL] Feliu, Ana Agusti Coutelier, Jean-Paul [UCL]

CD66a (CEACAM1), an adhesion molecule that has regulatory function on T lymphocytes, was found to be expressed on a minority of mouse natural killer (NK) cells, especially in the liver. CD66a expression on NK cells depended on their differentiation stage, with highest levels on immature CD49b(-)NK cells. Expression of CD66a on NK cells was strongly enhanced by in vitro activation with interleukin-12 (IL-12) and IL-18. However, in vivo NK cell stimulation by infection with lactate dehydrogenase-elevating virus did not lead to strong CD66a expression, even on activated interferon--gamma-producing NK cells. These results indicate that CD66a expression is differently regulated, depending on the NK cell activation pathway, which may lead to distinct regulatory mechanisms of the functional subpopulations of these cells.

Document type Article de périodique (Journal article) – Journal Article, Research Support, Non-U.S. Gov't
Access type Accès restreint
Publication date 2008
Journal information "Immunology" - Vol. 125, no. 4, p. 535-40 (2008)
Peer reviewed yes
e-issn 1365-2567
issn 0019-2805
Publication status Publié
Affiliation UCL - MD/MIGE - Département de microbiologie, d'immunologie et de génétique
MESH Subject Species Specificity ; NK Cell Lectin-Like Receptor Subfamily B - analysis ; Mice, Inbred C57BL ; Mice, Inbred BALB C ; Mice ; Lymphocyte Activation - immunology ; Liver - immunology - virology ; Lactate dehydrogenase-elevating virus ; Killer Cells, Natural - immunology ; Interferon-gamma - analysis ; Integrin alpha2 - analysis ; Flow Cytometry ; Female ; Cell Adhesion Molecules - analysis ; Arterivirus Infections - immunology ; Antigens, Ly - analysis ; Antigens, CD - analysis ; Animals
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Bibliographic reference Thirion, Gaëtan ; Feliu, Ana Agusti ; Coutelier, Jean-Paul. CD66a (CEACAM1) expression by mouse natural killer cells.. In: Immunology, Vol. 125, no. 4, p. 535-40 (2008)
Permanent URL http://hdl.handle.net/2078.1/12578