User menu

Accès à distance ? S'identifier sur le proxy UCLouvain

Antiviral Type I and Type III Interferon Responses in the Central Nervous System.

Primary tabs

download
  • Open access
  • PDF
  • 0.98 M
Sorgeloos, Frédéric [UCL] Kreit, Marguerite [UCL] Hermant, Pascale [UCL] Lardinois, Cécile [UCL] Michiels, Thomas [UCL]

The central nervous system (CNS) harbors highly differentiated cells, such as neurons that are essential to coordinate the functions of complex organisms. This organ is partly protected by the blood-brain barrier (BBB) from toxic substances and pathogens carried in the bloodstream. Yet, neurotropic viruses can reach the CNS either by crossing the BBB after viremia, or by exploiting motile infected cells as Trojan horses, or by using axonal transport. Type I and type III interferons (IFNs) are cytokines that are critical to control early steps of viral infections. Deficiencies in the IFN pathway have been associated with fatal viral encephalitis both in humans and mice. Therefore, the IFN system provides an essential protection of the CNS against viral infections. Yet, basal activity of the IFN system appears to be low within the CNS, likely owing to the toxicity of IFN to this organ. Moreover, after viral infection, neurons and oligodendrocytes were reported to be relatively poor IFN producers and appear to keep some susceptibility to neurotropic viruses, even in the presence of IFN. This review addresses some trends and recent developments concerning the role of type I and type III IFNs in: i) preventing neuroinvasion and infection of CNS cells; ii) the identity of IFN-producing cells in the CNS; iii) the antiviral activity of ISGs; and iv) the activity of viral proteins of neurotropic viruses that target the IFN pathway.

Document type Article de périodique (Journal article) – Article de recherche
Access type Accès libre
Publication date 2013
Language Anglais
Journal information "Viruses" - Vol. 5, no. 3, p. 834-857 (2013)
Peer reviewed yes
Publisher Molecular Diversity Preservation International (M D P I) ((Switzerland) Basel)
issn 1999-4915
e-issn 1999-4915
Publication status Publié
Affiliation UCL - SSS/DDUV - Institut de Duve
Links
  1. Binder G. K., Interferon-gamma -Mediated Site-Specific Clearance of Alphavirus from CNS Neurons, 10.1126/science.1059742
  2. Thompson Mikayla R., Kaminski John J., Kurt-Jones Evelyn A., Fitzgerald Katherine A., Pattern Recognition Receptors and the Innate Immune Response to Viral Infection, 10.3390/v3060920
  3. Paul Sophie, Ricour Céline, Sommereyns Caroline, Sorgeloos Frédéric, Michiels Thomas, Type I interferon response in the central nervous system, 10.1016/j.biochi.2007.02.009
  4. Muller U, Steinhoff U, Reis L., Hemmi S, Pavlovic J, Zinkernagel R., Aguet M, Functional role of type I and type II interferons in antiviral defense, 10.1126/science.8009221
  5. Ryman K. D., Klimstra W. B., Nguyen K. B., Biron C. A., Johnston R. E., Alpha/Beta Interferon Protects Adult Mice from Fatal Sindbis Virus Infection and Is an Important Determinant of Cell and Tissue Tropism, 10.1128/jvi.74.7.3366-3378.2000
  6. Leib David A., Harrison Travis E., Laslo Kathleen M., Machalek Michael A., Moorman Nathaniel J., Virgin Herbert W., Interferons Regulate the Phenotype of  Wild-type and Mutant Herpes Simplex Viruses In Vivo, 10.1084/jem.189.4.663
  7. Casrouge A., Zhang S.-Y., Eidenschenk C., Jouanguy E., Puel A., Yang K., Alcais A., Picard C., Mahfoufi N., Nicolas N., Lorenzo L., Plancoulaine S., Senechal B., Geissmann F., Tabeta K., Hoebe K., Du X., Miller R. L., Heron B., Mignot C., de Villemeur T. B., Lebon P., Dulac O., Rozenberg F., Beutler B., Tardieu M., Abel L., Casanova J.-L., Herpes Simplex Virus Encephalitis in Human UNC-93B Deficiency, 10.1126/science.1128346
  8. Herman Melina, Ciancanelli Michael, Ou Yi-Hung, Lorenzo Lazaro, Klaudel-Dreszler Maja, Pauwels Elodie, Sancho-Shimizu Vanessa, Pérez de Diego Rebeca, Abhyankar Avinash, Israelsson Elisabeth, Guo Yiqi, Cardon Annabelle, Rozenberg Flore, Lebon Pierre, Tardieu Marc, Heropolitańska-Pliszka Edyta, Chaussabel Damien, White Michael A., Abel Laurent, Zhang Shen-Ying, Casanova Jean-Laurent, HeterozygousTBK1mutations impair TLR3 immunity and underlie herpes simplex encephalitis of childhood, 10.1084/jem.20111316
  9. Pérez de Diego Rebeca, Sancho-Shimizu Vanessa, Lorenzo Lazaro, Puel Anne, Plancoulaine Sabine, Picard Capucine, Herman Melina, Cardon Annabelle, Durandy Anne, Bustamante Jacinta, Vallabhapurapu Sivakumar, Bravo Jerónimo, Warnatz Klaus, Chaix Yves, Cascarrigny Françoise, Lebon Pierre, Rozenberg Flore, Karin Michael, Tardieu Marc, Al-Muhsen Saleh, Jouanguy Emmanuelle, Zhang Shen-Ying, Abel Laurent, Casanova Jean-Laurent, Human TRAF3 Adaptor Molecule Deficiency Leads to Impaired Toll-like Receptor 3 Response and Susceptibility to Herpes Simplex Encephalitis, 10.1016/j.immuni.2010.08.014
  10. Sancho-Shimizu Vanessa, Pérez de Diego Rebeca, Lorenzo Lazaro, Halwani Rabih, Alangari Abdullah, Israelsson Elisabeth, Fabrega, Sylvie, Cardon Annabelle, Maluenda Jerome, Tatematsu Megumi, Mahvelati Farhad, Herman Melina, Ciancanelli Michael, Guo Yiqi, AlSum Zobaida, Alkhamis Nouf, Al-Makadma Abdulkarim S., Ghadiri Ata, Boucherit Soraya, Plancoulaine Sabine, Picard Capucine, Rozenberg Flore, Tardieu Marc, Lebon Pierre, Jouanguy Emmanuelle, Rezaei Nima, Seya Tsukasa, Matsumoto Misako, Chaussabel Damien, Puel Anne, Zhang Shen-Ying, Abel Laurent, Al-Muhsen Saleh, Casanova Jean-Laurent, Herpes simplex encephalitis in children with autosomal recessive and dominant TRIF deficiency, 10.1172/jci59259
  11. Zhang S.-Y., Jouanguy E., Ugolini S., Smahi A., Elain G., Romero P., Segal D., Sancho-Shimizu V., Lorenzo L., Puel A., Picard C., Chapgier A., Plancoulaine S., Titeux M., Cognet C., von Bernuth H., Ku C.-L., Casrouge A., Zhang X.-X., Barreiro L., Leonard J., Hamilton C., Lebon P., Heron B., Vallee L., Quintana-Murci L., Hovnanian A., Rozenberg F., Vivier E., Geissmann F., Tardieu M., Abel L., Casanova J.-L., TLR3 Deficiency in Patients with Herpes Simplex Encephalitis, 10.1126/science.1139522
  12. Sancho-Shimizu Vanessa, Perez de Diego Rebeca, Jouanguy Emmanuelle, Zhang Shen-Ying, Casanova Jean-Laurent, Inborn errors of anti-viral interferon immunity in humans, 10.1016/j.coviro.2011.10.016
  13. Yun N. E., Poussard A. L., Seregin A. V., Walker A. G., Smith J. K., Aronson J. F., Smith J. N., Soong L., Paessler S., Functional Interferon System Is Required for Clearance of Lassa Virus, 10.1128/jvi.06284-11
  14. Staeheli P., Sentandreu M., Pagenstecher A., Hausmann J., Alpha/Beta Interferon Promotes Transcription and Inhibits Replication of Borna Disease Virus in Persistently Infected Cells, 10.1128/jvi.75.17.8216-8223.2001
  15. Wichmann D., Grone H.-J., Frese M., Pavlovic J., Anheier B., Haller O., Klenk H.-D., Feldmann H., Hantaan Virus Infection Causes an Acute Neurological Disease That Is Fatal in Adult Laboratory Mice, 10.1128/jvi.76.17.8890-8899.2002
  16. Boyd A., Pathogenesis of Dugbe virus infection in wild-type and interferon-deficient mice, 10.1099/vir.0.81767-0
  17. Bereczky S., Lindegren G., Karlberg H., Akerstrom S., Klingstrom J., Mirazimi A., Crimean-Congo hemorrhagic fever virus infection is lethal for adult type I interferon receptor-knockout mice, 10.1099/vir.0.019034-0
  18. Blakqori G., Delhaye S., Habjan M., Blair C. D., Sanchez-Vargas I., Olson K. E., Attarzadeh-Yazdi G., Fragkoudis R., Kohl A., Kalinke U., Weiss S., Michiels T., Staeheli P., Weber F., La Crosse Bunyavirus Nonstructural Protein NSs Serves To Suppress the Type I Interferon System of Mammalian Hosts, 10.1128/jvi.01933-06
  19. Wernike Kerstin, Breithaupt Angele, Keller Markus, Hoffmann Bernd, Beer Martin, Eschbaumer Michael, Schmallenberg Virus Infection of Adult Type I Interferon Receptor Knock-Out Mice, 10.1371/journal.pone.0040380
  20. Ireland D. D. C., Stohlman S. A., Hinton D. R., Atkinson R., Bergmann C. C., Type I Interferons Are Essential in Controlling Neurotropic Coronavirus Infection Irrespective of Functional CD8 T Cells, 10.1128/jvi.01794-07
  21. Samuel M. A., Diamond M. S., Alpha/Beta Interferon Protects against Lethal West Nile Virus Infection by Restricting Cellular Tropism and Enhancing Neuronal Survival, 10.1128/jvi.79.21.13350-13361.2005
  22. Lobigs M., Role of type I and type II interferon responses in recovery from infection with an encephalitic flavivirus, 10.1099/vir.0.18654-0
  23. Shresta S., Kyle J. L., Snider H. M., Basavapatna M., Beatty P. R., Harris E., Interferon-Dependent Immunity Is Essential for Resistance to Primary Dengue Virus Infection in Mice, Whereas T- and B-Cell-Dependent Immunity Are Less Critical, 10.1128/jvi.78.6.2701-2710.2004
  24. Garcia-Sastre, J. Virol., 72, 8550 (1998)
  25. Kochs G., Bauer S., Vogt C., Frenz T., Tschopp J., Kalinke U., Waibler Z., Thogoto Virus Infection Induces Sustained Type I Interferon Responses That Depend on RIG-I-Like Helicase Signaling of Conventional Dendritic Cells, 10.1128/jvi.00931-10
  26. Mrkic, J. Virol., 72, 7420 (1998)
  27. Dhondt, J. Infect. Dis., 1, 142 (2012)
  28. Ida-Hosonuma M., Iwasaki T., Yoshikawa T., Nagata N., Sato Y., Sata T., Yoneyama M., Fujita T., Taya C., Yonekawa H., Koike S., The Alpha/Beta Interferon Response Controls Tissue Tropism and Pathogenicity of Poliovirus, 10.1128/jvi.79.7.4460-4469.2005
  29. Fiette L., Theiler's virus infection of 129Sv mice that lack the interferon alpha/beta or interferon gamma receptors, 10.1084/jem.181.6.2069
  30. Ricour C., Delhaye S., Hato S. V., Olenyik T. D., Michel B., van Kuppeveld F. J. M., Gustin K. E., Michiels T., Inhibition of mRNA export and dimerization of interferon regulatory factor 3 by Theiler's virus leader protein, 10.1099/vir.0.005678-0
  31. Dionne Kalen R., Galvin John M., Schittone Stephanie A., Clarke Penny, Tyler Kenneth L., Type I interferon signaling limits reoviral tropism within the brain and prevents lethal systemic infection, 10.1007/s13365-011-0038-1
  32. Detje C. N., Meyer T., Schmidt H., Kreuz D., Rose J. K., Bechmann I., Prinz M., Kalinke U., Local Type I IFN Receptor Signaling Protects against Virus Spread within the Central Nervous System, 10.4049/jimmunol.0800596
  33. Marschalek A., Finke S., Schwemmle M., Mayer D., Heimrich B., Stitz L., Conzelmann K.-K., Attenuation of Rabies Virus Replication and Virulence by Picornavirus Internal Ribosome Entry Site Elements, 10.1128/jvi.02055-08
  34. White L. J., Wang J.-g., Davis N. L., Johnston R. E., Role of Alpha/Beta Interferon in Venezuelan Equine Encephalitis Virus Pathogenesis: Effect of an Attenuating Mutation in the 5' Untranslated Region, 10.1128/jvi.75.8.3706-3718.2001
  35. Couderc Thérèse, Chrétien Fabrice, Schilte Clémentine, Disson Olivier, Brigitte Madly, Guivel-Benhassine Florence, Touret Yasmina, Barau Georges, Cayet Nadège, Schuffenecker Isabelle, Desprès Philippe, Arenzana-Seisdedos Fernando, Michault Alain, Albert Matthew L., Lecuit Marc, A Mouse Model for Chikungunya: Young Age and Inefficient Type-I Interferon Signaling Are Risk Factors for Severe Disease, 10.1371/journal.ppat.0040029
  36. Aguilar P. V., Paessler S., Carrara A.-S., Baron S., Poast J., Wang E., Moncayo A. C., Anishchenko M., Watts D., Tesh R. B., Weaver S. C., Variation in Interferon Sensitivity and Induction among Strains of Eastern Equine Encephalitis Virus, 10.1128/jvi.79.17.11300-11310.2005
  37. Hwang S. Y., Hertzog P. J., Holland K. A., Sumarsono S. H., Tymms M. J., Hamilton J. A., Whitty G., Bertoncello I., Kola I., A null mutation in the gene encoding a type I interferon receptor component eliminates antiproliferative and antiviral responses to interferons alpha and beta and alters macrophage responses., 10.1073/pnas.92.24.11284
  38. Fragkoudis R., Breakwell L., McKimmie C., Boyd A., Barry G., Kohl A., Merits A., Fazakerley J. K., The type I interferon system protects mice from Semliki Forest virus by preventing widespread virus dissemination in extraneural tissues, but does not mediate the restricted replication of avirulent virus in central nervous system neurons, 10.1099/vir.0.83191-0
  39. Haller O., Genetically determined, interferon-dependent resistance to influenza virus in mice, 10.1084/jem.149.3.601
  40. Tovey M. G., Streuli M., Gresser I., Gugenheim J., Blanchard B., Guymarho J., Vignaux F., Gigou M., Interferon messenger RNA is produced constitutively in the organs of normal individuals., 10.1073/pnas.84.14.5038
  41. Taniguchi Tadatsugu, Takaoka Akinori, A weak signal for strong responses: interferon-alpha/beta revisited, 10.1038/35073080
  42. Fritz-French Cari, Tyor William, Interferon-α (IFNα) neurotoxicity, 10.1016/j.cytogfr.2012.01.001
  43. Lebon Pierre, Badoual Jean, Ponsot Gérard, Goutières Françoise, Hémeury-Cukier Françoise, Aicardi Jean, Intrathecal synthesis of interferon-alpha in infants with progressive familial encephalopathy, 10.1016/0022-510x(88)90125-6
  44. Crow Yanick J, Hayward Bruce E, Parmar Rekha, Robins Peter, Leitch Andrea, Ali Manir, Black Deborah N, van Bokhoven Hans, Brunner Han G, Hamel Ben C, Corry Peter C, Cowan Frances M, Frints Suzanne G, Klepper Joerg, Livingston John H, Lynch Sally Ann, Massey Roger F, Meritet Jean François, Michaud Jacques L, Ponsot Gerard, Voit Thomas, Lebon Pierre, Bonthron David T, Jackson Andrew P, Barnes Deborah E, Lindahl Tomas, Mutations in the gene encoding the 3′-5′ DNA exonuclease TREX1 cause Aicardi-Goutières syndrome at the AGS1 locus, 10.1038/ng1845
  45. Crow Yanick J, Leitch Andrea, Hayward Bruce E, Garner Anna, Parmar Rekha, Griffith Elen, Ali Manir, Semple Colin, Aicardi Jean, Babul-Hirji Riyana, Baumann Clarisse, Baxter Peter, Bertini Enrico, Chandler Kate E, Chitayat David, Cau Daniel, Déry Catherine, Fazzi Elisa, Goizet Cyril, King Mary D, Klepper Joerg, Lacombe Didier, Lanzi Giovanni, Lyall Hermione, Martínez-Frías María Luisa, Mathieu Michèle, McKeown Carole, Monier Anne, Oade Yvette, Quarrell Oliver W, Rittey Christopher D, Rogers R Curtis, Sanchis Amparo, Stephenson John B P, Tacke Uta, Till Marianne, Tolmie John L, Tomlin Pam, Voit Thomas, Weschke Bernhard, Woods C Geoffrey, Lebon Pierre, Bonthron David T, Ponting Chris P, Jackson Andrew P, Mutations in genes encoding ribonuclease H2 subunits cause Aicardi-Goutières syndrome and mimic congenital viral brain infection, 10.1038/ng1842
  46. Rice Gillian I, Kasher Paul R, Forte Gabriella M A, Mannion Niamh M, Greenwood Sam M, Szynkiewicz Marcin, Dickerson Jonathan E, Bhaskar Sanjeev S, Zampini Massimiliano, Briggs Tracy A, Jenkinson Emma M, Bacino Carlos A, Battini Roberta, Bertini Enrico, Brogan Paul A, Brueton Louise A, Carpanelli Marialuisa, De Laet Corinne, de Lonlay Pascale, del Toro Mireia, Desguerre Isabelle, Fazzi Elisa, Garcia-Cazorla Àngels, Heiberg Arvid, Kawaguchi Masakazu, Kumar Ram, Lin Jean-Pierre S-M, Lourenco Charles M, Male Alison M, Marques Wilson, Mignot Cyril, Olivieri Ivana, Orcesi Simona, Prabhakar Prab, Rasmussen Magnhild, Robinson Robert A, Rozenberg Flore, Schmidt Johanna L, Steindl Katharina, Tan Tiong Y, van der Merwe William G, Vanderver Adeline, Vassallo Grace, Wakeling Emma L, Wassmer Evangeline, Whittaker Elizabeth, Livingston John H, Lebon Pierre, Suzuki Tamio, McLaughlin Paul J, Keegan Liam P, O'Connell Mary A, Lovell Simon C, Crow Yanick J, Mutations in ADAR1 cause Aicardi-Goutières syndrome associated with a type I interferon signature, 10.1038/ng.2414
  47. Kotenko Sergei V., Gallagher Grant, Baurin Vitaliy V., Lewis-Antes Anita, Shen Meiling, Shah Nital K., Langer Jerome A., Sheikh Faruk, Dickensheets Harold, Donnelly Raymond P., IFN-λs mediate antiviral protection through a distinct class II cytokine receptor complex, 10.1038/ni875
  48. Sheppard Paul, Kindsvogel Wayne, Xu Wenfeng, Henderson Katherine, Schlutsmeyer Stacy, Whitmore Theodore E., Kuestner Rolf, Garrigues Ursula, Birks Carl, Roraback Jenny, Ostrander Craig, Dong Dennis, Shin Jinu, Presnell Scott, Fox Brian, Haldeman Betty, Cooper Emily, Taft David, Gilbert Teresa, Grant Francis J., Tackett Monica, Krivan William, McKnight Gary, Clegg Chris, Foster Don, Klucher Kevin M., IL-28, IL-29 and their class II cytokine receptor IL-28R, 10.1038/ni873
  49. Lasfar Ahmed, Lewis-Antes Anita, Smirnov Sergey V., Anantha Shubha, Abushahba Walid, Tian Bin, Reuhl Kenneth, Dickensheets Harold, Sheikh Faruk, Donnelly Raymond P., Raveche Elizabeth, Kotenko Sergei V., Characterization of the Mouse IFN-λ Ligand-Receptor System: IFN-λs Exhibit Antitumor Activity against B16 Melanoma, 10.1158/0008-5472.can-05-3653
  50. DUMOUTIER Laure, LEJEUNE Diane, HOR Simon, FICKENSCHER Helmut, RENAULD Jean-Christophe, Cloning of a new type II cytokine receptor activating signal transducer and activator of transcription (STAT)1, STAT2 and STAT3, 10.1042/bj20021935
  51. Ank N., West H., Bartholdy C., Eriksson K., Thomsen A. R., Paludan S. R., Lambda Interferon (IFN- ), a Type III IFN, Is Induced by Viruses and IFNs and Displays Potent Antiviral Activity against Select Virus Infections In Vivo, 10.1128/jvi.80.9.4501-4509.2006
  52. Dumoutier Laure, Tounsi Amel, Michiels Thomas, Sommereyns Caroline, Kotenko Sergei V., Renauld Jean-Christophe, Role of the Interleukin (IL)-28 Receptor Tyrosine Residues for Antiviral and Antiproliferative Activity of IL-29/Interferon-λ1 : SIMILARITIES WITH TYPE I INTERFERON SIGNALING, 10.1074/jbc.m404789200
  53. Li Jieliang, Hu Shuxian, Zhou Lin, Ye Li, Wang Xu, Ho Jie, Ho Wenzhe, Interferon lambda inhibits herpes simplex virus type I infection of human astrocytes and neurons, 10.1002/glia.21076
  54. Sommereyns Caroline, Paul Sophie, Staeheli Peter, Michiels Thomas, IFN-Lambda (IFN-λ) Is Expressed in a Tissue-Dependent Fashion and Primarily Acts on Epithelial Cells In Vivo, 10.1371/journal.ppat.1000017
  55. Zhou L., Wang X., Wang Y.J., Zhou Y., Hu S., Ye L., Hou W., Li H., Ho W.Z., Activation of Toll-like receptor-3 induces interferon-λ expression in human neuronal cells, 10.1016/j.neuroscience.2008.12.036
  56. Mordstein Markus, Michiels Thomas, Staeheli Peter, What Have We Learned from the IL28 Receptor Knockout Mouse?, 10.1089/jir.2010.0061
  57. Asselin-Paturel Carine, Boonstra Andre, Dalod Marc, Durand Isabelle, Yessaad Nadia, Dezutter-Dambuyant Colette, Vicari Alain, O'Garra Anne, Biron Christine, Brière Francine, Trinchieri Giorgio, Mouse type I IFN-producing cells are immature APCs with plasmacytoid morphology, 10.1038/ni736
  58. Cervantes-Barragan L., Zust R., Weber F., Spiegel M., Lang K. S., Akira S., Thiel V., Ludewig B., Control of coronavirus infection through plasmacytoid dendritic-cell-derived type I interferon, 10.1182/blood-2006-05-023770
  59. Daffis S., Samuel M. A., Suthar M. S., Gale M., Diamond M. S., Toll-Like Receptor 3 Has a Protective Role against West Nile Virus Infection, 10.1128/jvi.00935-08
  60. Prehaud C., Megret F., Lafage M., Lafon M., Virus Infection Switches TLR-3-Positive Human Neurons To Become Strong Producers of Beta Interferon, 10.1128/jvi.79.20.12893-12904.2005
  61. Delhaye S., Paul S., Blakqori G., Minet M., Weber F., Staeheli P., Michiels T., Neurons produce type I interferon during viral encephalitis, 10.1073/pnas.0602460103
  62. Kallfass C., Ackerman A., Lienenklaus S., Weiss S., Heimrich B., Staeheli P., Visualizing Production of Beta Interferon by Astrocytes and Microglia in Brain of La Crosse Virus-Infected Mice, 10.1128/jvi.01093-12
  63. Lienenklaus S., Cornitescu M., Zietara N., Lyszkiewicz M., Gekara N., Jablonska J., Edenhofer F., Rajewsky K., Bruder D., Hafner M., Staeheli P., Weiss S., Novel Reporter Mouse Reveals Constitutive and Inflammatory Expression of IFN-  In Vivo, 10.4049/jimmunol.0804277
  64. Roth-Cross J. K., Bender S. J., Weiss S. R., Murine Coronavirus Mouse Hepatitis Virus Is Recognized by MDA5 and Induces Type I Interferon in Brain Macrophages/Microglia, 10.1128/jvi.01199-08
  65. Kapil Parul, Butchi Niranjan B., Stohlman Stephen A., Bergmann Cornelia C., Oligodendroglia are limited in type I interferon induction and responsiveness in vivo, 10.1002/glia.22375
  66. Kalinke Ulrich, Bechmann Ingo, Detje Claudia N., Host strategies against virus entry via the olfactory system, 10.4161/viru.2.4.16138
  67. Ohka S., Igarashi H., Nagata N., Sakai M., Koike S., Nochi T., Kiyono H., Nomoto A., Establishment of a Poliovirus Oral Infection System in Human Poliovirus Receptor-Expressing Transgenic Mice That Are Deficient in Alpha/Beta Interferon Receptor, 10.1128/jvi.02675-06
  68. Chopy Damien, Detje Claudia N., Lafage Mireille, Kalinke Ulrich, Lafon Monique, The type I interferon response bridles rabies virus infection and reduces pathogenicity, 10.1007/s13365-011-0041-6
  69. Vignuzzi Marco, Stone Jeffrey K., Arnold Jamie J., Cameron Craig E., Andino Raul, Quasispecies diversity determines pathogenesis through cooperative interactions in a viral population, 10.1038/nature04388
  70. Lancaster Karen Z., Pfeiffer Julie K., Limited Trafficking of a Neurotropic Virus Through Inefficient Retrograde Axonal Transport and the Type I Interferon Response, 10.1371/journal.ppat.1000791
  71. Njenga, J. Tech. Meth. Pathol., 77, 71 (1997)
  72. Ousman S. S., Wang J., Campbell I. L., Differential Regulation of Interferon Regulatory Factor (IRF)-7 and IRF-9 Gene Expression in the Central Nervous System during Viral Infection, 10.1128/jvi.79.12.7514-7527.2005
  73. Chevalier Grégoire, Suberbielle Elsa, Monnet Céline, Duplan Valérie, Martin-Blondel Guillaume, Farrugia Fanny, Le Masson Gwendal, Liblau Roland, Gonzalez-Dunia Daniel, Neurons are MHC Class I-Dependent Targets for CD8 T Cells upon Neurotropic Viral Infection, 10.1371/journal.ppat.1002393
  74. Neumann H, Cavalie A, Jenne D., Wekerle H, Induction of MHC class I genes in neurons, 10.1126/science.7624779
  75. Griffin Diane E, Metcalf Talibah, Clearance of virus infection from the CNS, 10.1016/j.coviro.2011.05.021
  76. Yordy Brian, Iijima Norifumi, Huttner Anita, Leib David, Iwasaki Akiko, A Neuron-Specific Role for Autophagy in Antiviral Defense against Herpes Simplex Virus, 10.1016/j.chom.2012.07.013
  77. Zhao Pingsen, Zhao Lili, Zhang Tao, Qi Yinglin, Wang Tiecheng, Liu Kejian, Wang Hualei, Feng Hao, Jin Hongli, Qin Chuan, Yang Songtao, Xia Xianzhu, Innate immune response gene expression profiles in central nervous system of mice infected with rabies virus, 10.1016/j.cimid.2011.09.003
  78. de Veer, J. Leukoc. Biol., 69, 912 (2001)
  79. Der S. D., Zhou A., Williams B. R. G., Silverman R. H., Identification of genes differentially regulated by interferon  ,  , or   using oligonucleotide arrays, 10.1073/pnas.95.26.15623
  80. Zhou Z., Hamming O. J., Ank N., Paludan S. R., Nielsen A. L., Hartmann R., Type III Interferon (IFN) Induces a Type I IFN-Like Response in a Restricted Subset of Cells through Signaling Pathways Involving both the Jak-STAT Pathway and the Mitogen-Activated Protein Kinases, 10.1128/jvi.02438-06
  81. Sadler Anthony J., Williams Bryan R. G., Interferon-inducible antiviral effectors, 10.1038/nri2314
  82. Liu Su-Yang, Sanchez David Jesse, Cheng Genhong, New developments in the induction and antiviral effectors of type I interferon, 10.1016/j.coi.2010.11.003
  83. Hug, Mol. Cell. Biol., 8, 3065 (1988)
  84. Sheehy Ann M., Gaddis Nathan C., Choi Jonathan D., Malim Michael H., Isolation of a human gene that inhibits HIV-1 infection and is suppressed by the viral Vif protein, 10.1038/nature00939
  85. Geoffroy Marie-Claude, Chelbi-Alix Mounira K., Role of Promyelocytic Leukemia Protein in Host Antiviral Defense, 10.1089/jir.2010.0111
  86. Liu S.-Y., Sanchez D. J., Aliyari R., Lu S., Cheng G., Systematic identification of type I and type II interferon-induced antiviral factors, 10.1073/pnas.1114981109
  87. Schoggins John W., Wilson Sam J., Panis Maryline, Murphy Mary Y., Jones Christopher T., Bieniasz Paul, Rice Charles M., A diverse range of gene products are effectors of the type I interferon antiviral response, 10.1038/nature09907
  88. Fensterl Volker, Wetzel Jaime L., Ramachandran Srividya, Ogino Tomoaki, Stohlman Stephen A., Bergmann Cornelia C., Diamond Michael S., Virgin Herbert W., Sen Ganes C., Interferon-Induced Ifit2/ISG54 Protects Mice from Lethal VSV Neuropathogenesis, 10.1371/journal.ppat.1002712
  89. Brzozka K., Finke S., Conzelmann K.-K., Identification of the Rabies Virus Alpha/Beta Interferon Antagonist: Phosphoprotein P Interferes with Phosphorylation of Interferon Regulatory Factor 3, 10.1128/jvi.79.12.7673-7681.2005
  90. Brzozka K., Finke S., Conzelmann K.-K., Inhibition of Interferon Signaling by Rabies Virus Phosphoprotein P: Activation-Dependent Binding of STAT1 and STAT2, 10.1128/jvi.80.6.2675-2683.2006
  91. Vidy A., Chelbi-Alix M., Blondel D., Rabies Virus P Protein Interacts with STAT1 and Inhibits Interferon Signal Transduction Pathways, 10.1128/jvi.79.22.14411-14420.2005
  92. Vidy A., El Bougrini J., Chelbi-Alix M. K., Blondel D., The Nucleocytoplasmic Rabies Virus P Protein Counteracts Interferon Signaling by Inhibiting both Nuclear Accumulation and DNA Binding of STAT1, 10.1128/jvi.01930-06
  93. Ito N., Moseley G. W., Blondel D., Shimizu K., Rowe C. L., Ito Y., Masatani T., Nakagawa K., Jans D. A., Sugiyama M., Role of Interferon Antagonist Activity of Rabies Virus Phosphoprotein in Viral Pathogenicity, 10.1128/jvi.00011-10
  94. Rieder M., Brzozka K., Pfaller C. K., Cox J. H., Stitz L., Conzelmann K.-K., Genetic Dissection of Interferon-Antagonistic Functions of Rabies Virus Phosphoprotein: Inhibition of Interferon Regulatory Factor 3 Activation Is Important for Pathogenicity, 10.1128/jvi.01427-10
  95. Blondel Danielle, Kheddache Sabrina, Lahaye Xavier, Dianoux Laurent, Chelbi-Alix Mounira K., Resistance to Rabies Virus Infection Conferred by the PMLIV Isoform, 10.1128/jvi.01286-10
  96. Blondel Danielle, Regad Tarick, Poisson Nicolas, Pavie Benjamen, Harper Francis, Pandolfi Pier Paolo, de Thé Hugues, Chelbi-Alix Mounira K, Rabies virus P and small P products interact directly with PML and reorganize PML nuclear bodies, 10.1038/sj.onc.1205931
  97. Chelbi-Alix, J. Virol., 72, 1043 (1998)
  98. Andrejeva J., Childs K. S., Young D. F., Carlos T. S., Stock N., Goodbourn S., Randall R. E., The V proteins of paramyxoviruses bind the IFN-inducible RNA helicase, mda-5, and inhibit its activation of the IFN-  promoter, 10.1073/pnas.0407639101
  99. Childs Kay, Stock Nicola, Ross Craig, Andrejeva Jelena, Hilton Louise, Skinner Michael, Randall Richard, Goodbourn Stephen, mda-5, but not RIG-I, is a common target for paramyxovirus V proteins, 10.1016/j.virol.2006.09.023
  100. Parisien J.-P., Bamming D., Komuro A., Ramachandran A., Rodriguez J. J., Barber G., Wojahn R. D., Horvath C. M., A Shared Interface Mediates Paramyxovirus Interference with Antiviral RNA Helicases MDA5 and LGP2, 10.1128/jvi.00153-09
  101. Shaw M. L., Garcia-Sastre A., Palese P., Basler C. F., Nipah Virus V and W Proteins Have a Common STAT1-Binding Domain yet Inhibit STAT1 Activation from the Cytoplasmic and Nuclear Compartments, Respectively, 10.1128/jvi.78.11.5633-5641.2004
  102. Rodriguez J. J., Parisien J.-P., Horvath C. M., Nipah Virus V Protein Evades Alpha and Gamma Interferons by Preventing STAT1 and STAT2 Activation and Nuclear Accumulation, 10.1128/jvi.76.22.11476-11483.2002
  103. Rodriguez J. J., Wang L.-F., Horvath C. M., Hendra Virus V Protein Inhibits Interferon Signaling by Preventing STAT1 and STAT2 Nuclear Accumulation, 10.1128/jvi.77.21.11842-11845.2003
  104. Park M.-S., Shaw M. L., Munoz-Jordan J., Cros J. F., Nakaya T., Bouvier N., Palese P., Garcia-Sastre A., Basler C. F., Newcastle Disease Virus (NDV)-Based Assay Demonstrates Interferon-Antagonist Activity for the NDV V Protein and the Nipah Virus V, W, and C Proteins, 10.1128/jvi.77.2.1501-1511.2003
  105. Shaw M. L., Cardenas W. B., Zamarin D., Palese P., Basler C. F., Nuclear Localization of the Nipah Virus W Protein Allows for Inhibition of both Virus- and Toll-Like Receptor 3-Triggered Signaling Pathways, 10.1128/jvi.79.10.6078-6088.2005
  106. van Pesch V., van Eyll O., Michiels T., The Leader Protein of Theiler's Virus Inhibits Immediate-Early Alpha/Beta Interferon Production, 10.1128/jvi.75.17.7811-7817.2001
  107. Hato Stanleyson V., Ricour Celine, Schulte Barbara M., Lanke Kjerstin H. W., de Bruijni Mike, Zoll Jan, Melchers Willem J. G., Michiels Thomas, van Kuppeveld Frank J. M., The mengovirus leader protein blocks interferon-α/β gene transcription and inhibits activation of interferon regulatory factor 3 : Mengovirus L blocks IFN transcription and IRF-3 activation, 10.1111/j.1462-5822.2007.01006.x
  108. Paul S., Cardiovirus leader proteins are functionally interchangeable and have evolved to adapt to virus replication fitness, 10.1099/vir.0.81642-0
  109. Papon Laura, Oteiza Alexandra, Imaizumi Tadaatsu, Kato Hiroki, Brocchi Emiliana, Lawson T. Glen, Akira Shizuo, Mechti Nadir, The viral RNA recognition sensor RIG-I is degraded during encephalomyocarditis virus (EMCV) infection, 10.1016/j.virol.2009.08.009
  110. Mukherjee Amitava, Morosky Stefanie A., Delorme-Axford Elizabeth, Dybdahl-Sissoko Naomi, Oberste M. Steven, Wang Tianyi, Coyne Carolyn B., The Coxsackievirus B 3Cpro Protease Cleaves MAVS and TRIF to Attenuate Host Type I Interferon and Apoptotic Signaling, 10.1371/journal.ppat.1001311
  111. Morrison J. M., Racaniello V. R., Proteinase 2Apro Is Essential for Enterovirus Replication in Type I Interferon-Treated Cells, 10.1128/jvi.02177-08
  112. Etchison, J. Biol. Chem., 257, 14806 (1982)
  113. Barral Paola M., Sarkar Devanand, Fisher Paul B., Racaniello Vincent R., RIG-I is cleaved during picornavirus infection, 10.1016/j.virol.2009.06.045
  114. de Breyne Sylvain, Bonderoff Jennifer M., Chumakov Konstantin M., Lloyd Richard E., Hellen Christopher U.T., Cleavage of eukaryotic initiation factor eIF5B by enterovirus 3C proteases, 10.1016/j.virol.2008.05.019
  115. Neznanov Nickolay, Chumakov Konstantin M., Neznanova Lubov, Almasan Alexandru, Banerjee Amiya K., Gudkov Andrei V., Proteolytic Cleavage of the p65-RelA Subunit of NF-κB during Poliovirus Infection, 10.1074/jbc.m502303200
  116. Lu J., Yi L., Zhao J., Yu J., Chen Y., Lin M. C., Kung H.-F., He M.-L., Enterovirus 71 Disrupts Interferon Signaling by Reducing the Level of Interferon Receptor 1, 10.1128/jvi.06687-11
  117. Lei X., Liu X., Ma Y., Sun Z., Yang Y., Jin Q., He B., Wang J., The 3C Protein of Enterovirus 71 Inhibits Retinoid Acid-Inducible Gene I-Mediated Interferon Regulatory Factor 3 Activation and Type I Interferon Responses, 10.1128/jvi.02491-09
  118. Lei X., Sun Z., Liu X., Jin Q., He B., Wang J., Cleavage of the Adaptor Protein TRIF by Enterovirus 71 3C Inhibits Antiviral Responses Mediated by Toll-Like Receptor 3, 10.1128/jvi.00447-11
  119. Aguirre Sebastian, Maestre Ana M., Pagni Sarah, Patel Jenish R., Savage Timothy, Gutman Delia, Maringer Kevin, Bernal-Rubio Dabeiba, Shabman Reed S., Simon Viviana, Rodriguez-Madoz Juan R., Mulder Lubbertus C. F., Barber Glen N., Fernandez-Sesma Ana, DENV Inhibits Type I IFN Production in Infected Cells by Cleaving Human STING, 10.1371/journal.ppat.1002934
  120. Yu Chia-Yi, Chang Tsung-Hsien, Liang Jian-Jong, Chiang Ruei-Lin, Lee Yi-Ling, Liao Ching-Len, Lin Yi-Ling, Dengue Virus Targets the Adaptor Protein MITA to Subvert Host Innate Immunity, 10.1371/journal.ppat.1002780
  121. Ventoso I., Blanco R., Perales C., Carrasco L., HIV-1 protease cleaves eukaryotic initiation factor 4G and inhibits cap-dependent translation, 10.1073/pnas.231343498
  122. Solis M., Nakhaei P., Jalalirad M., Lacoste J., Douville R., Arguello M., Zhao T., Laughrea M., Wainberg M. A., Hiscott J., RIG-I-Mediated Antiviral Signaling Is Inhibited in HIV-1 Infection by a Protease-Mediated Sequestration of RIG-I, 10.1128/jvi.01635-10
  123. Wang Gang, Chen Gang, Zheng Dahai, Cheng Genhong, Tang Hong, PLP2 of Mouse Hepatitis Virus A59 (MHV-A59) Targets TBK1 to Negatively Regulate Cellular Type I Interferon Signaling Pathway, 10.1371/journal.pone.0017192
  124. Sun Li, Xing Yaling, Chen Xiaojuan, Zheng Yang, Yang Yudong, Nichols Daniel B., Clementz Mark A., Banach Bridget S., Li Kui, Baker Susan C., Chen Zhongbin, Coronavirus Papain-like Proteases Negatively Regulate Antiviral Innate Immune Response through Disruption of STING-Mediated Signaling, 10.1371/journal.pone.0030802
Bibliographic reference Sorgeloos, Frédéric ; Kreit, Marguerite ; Hermant, Pascale ; Lardinois, Cécile ; Michiels, Thomas. Antiviral Type I and Type III Interferon Responses in the Central Nervous System.. In: Viruses, Vol. 5, no. 3, p. 834-857 (2013)
Permanent URL http://hdl.handle.net/2078.1/127334