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Differential expression of the TEF family of transcription factors in the murine placenta and during differentiation of primary human trophoblasts in vitro.

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Jacquemin, Patrick [UCL] Sapin, V Alsat, E Evain-Brion, D Dollé, P Davidson, I

We describe the molecular cloning of murine (m) Transcriptional Enhancer Factor (TEF)-5 belonging to the TEF family of transcription factors. We show that mTEF-5 is specifically expressed in trophoblast giant cells and other extra-embryonic structures at early stages of development. At later stages, mTEF-5 is specifically expressed in the labyrinthine region of the placenta and in several embryonic tissues. We further show that the other mTEFs are differentially expressed in extraembryonic structures and in the mature placenta. Interestingly, human (h)TEF-5 is specifically expressed in the differentiated syncytiotrophoblast of the human term placenta and its expression is upregulated during the differentiation of cytotrophoblasts to syncytiotrophoblast in vitro, whereas that of hTEF-1 is down-regulated. Together with previous results describing hTEF-binding sites in the human placental lactogen-B gene enhancer, these novel observations support a role for hTEF-5 in the regulation of this gene. We further propose that the hTEF factors may play a more general role in placental gene regulation and development.

Document type Article de périodique (Journal article)
Publication date 1998
Language Anglais
Journal information "Developmental Dynamics" - Vol. 212, no.3, p. 423-36 (1998)
Peer reviewed yes
Publisher JohnWiley & Sons, Inc. ((United States) Hoboken)
issn 1058-8388
e-issn 1097-0177
Publication status Publié
Affiliation UCL - SSS/DDUV - Institut de Duve
MESH Subject Amino Acid Sequence ; Mice ; Molecular Sequence Data ; Placenta ; Transcription Factors ; Trophoblasts ; Up-Regulation ; Animals ; Base Sequence ; Cell Differentiation ; Cells, Cultured ; Cloning, Molecular ; DNA-Binding Proteins ; Gene Expression Regulation, Developmental ; Humans
Links
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Bibliographic reference Jacquemin, Patrick ; Sapin, V ; Alsat, E ; Evain-Brion, D ; Dollé, P ; et. al. Differential expression of the TEF family of transcription factors in the murine placenta and during differentiation of primary human trophoblasts in vitro.. In: Developmental Dynamics, Vol. 212, no.3, p. 423-36 (1998)
Permanent URL http://hdl.handle.net/2078.1/132099