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Prevention of microvascular diabetic complications by fenofibrate: lessons from FIELD and ACCORD.

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Hermans, Michel [UCL]

Microvascular complications are common in type 2 diabetes in primary care. Intensified management of glycaemia or blood pressure had little effect on microvascular complication rates in recent large trials (ADVANCE, VADT, ACCORD). In 2005, the FIELD study demonstrated a significant reduction in the need for laser treatment for retinopathy, and of progression of renal dysfunction, with fenofibrate versus placebo. The FIELD ophthalmology sub-study showed that fenofibrate reduced the risk of new retinopathy and progression of retinopathy. Also, fenofibrate versus placebo significantly reduced the risk of non-traumatic, diabetes-related amputations in a post-hoc analysis from FIELD. Recently, the results of the ACCORD Lipid study were consistent with these findings, as fenofibrate significantly reduced progression of retinopathy and albuminuria, apparently independent of effects on lipids. These findings suggest a role for fenofibrate in the prevention of major diabetic microvascular complications.

Document type Article de périodique (Journal article) – Synthèse de littérature
Access type Accès restreint
Publication date 2011
Language Anglais
Journal information "Diabetes and Vascular Disease Research" - Vol. 8, no.3, p. 180-189 (2011)
Peer reviewed yes
Publisher Sage Publications Ltd. ((United Kingdom) London)
issn 1479-1641
e-issn 1752-8984
Publication status Publié
Affiliations UCL - SSS/IREC/CARD - Pôle de recherche cardiovasculaire
UCL - (SLuc) Service d'endocrinologie et de nutrition
MESH Subject Albuminuria ; Randomized Controlled Trials as Topic ; Treatment Outcome ; Diabetes Mellitus, Type 1 ; Diabetic Retinopathy ; Evidence-Based Medicine ; Fenofibrate ; Humans ; Lower Extremity ; Microvessels ; Peripheral Arterial Disease
Links
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Bibliographic reference Hermans, Michel. Prevention of microvascular diabetic complications by fenofibrate: lessons from FIELD and ACCORD.. In: Diabetes and Vascular Disease Research, Vol. 8, no.3, p. 180-189 (2011)
Permanent URL http://hdl.handle.net/2078.1/132380