User menu

Accès à distance ? S'identifier sur le proxy UCLouvain

Acute occlusive ischemia of the rat intestine: early detection by MR imaging with polylysine-Gd-DTPA enhancement.

Primary tabs

Van Beers, Bernard [UCL] Mottet, I. [UCL] Delos, Monique [UCL] Goudemant, Jean-François [UCL] Demeure, R. [UCL] Pringot, Jacques [UCL]

The purpose of this study was to assess the potential role of MR imaging with polylysine-Gd-DTPA enhancement in the early detection of acute occlusive intestinal ischemia in a rat model. After devascularization of the distal ileum in 12 rats, T2-weighted fast spin-echo MR images were acquired, followed by T1-weighted images before and after IV administration of 0.1 mmol/kg polylysine-Gd-DTPA. The signal intensity of the ischemic intestine did not differ significantly from that of the normal intestine before the administration of the contrast material. No mucosal or submucosal edema or hemorrhage was found in the ischemic intestine at histologic examination. After the administration of polylysine-Gd-DTPA, the ischemic intestine lacked enhancement and its signal intensity was significantly lower than that of the normal intestine. MR imaging with polylysine-Gd-DTPA enhancement can detect acute occlusive ischemia of the rat intestine at an early stage.

  1. Stoney, Surgery, 114, 489 (1993)
  2. Alpern M B, Glazer G M, Francis I R, Ischemic or infarcted bowel: CT findings., 10.1148/radiology.166.1.3336673
  3. Smerud M J, Johnson C D, Stephens D H, Diagnosis of bowel infarction: a comparison of plain films and CT scans in 23 cases., 10.2214/ajr.154.1.2104734
  4. Zarins, Surg Gynecol Obstet, 138, 576 (1974)
  5. Oster Z H, Som P, Zamora P O, Mesenteric vascular occlusion: a new diagnostic method using a radiolabeled monoclonal antibody reactive with platelets., 10.1148/radiology.171.3.2717735
  6. Lynch Thomas G., Doppler Ultrasound, Laser Doppler, and Perfusion Fluorometry in Bowel Ischemia, 10.1001/archsurg.1988.01400280093017
  7. Kaufman, Invest Radio1, 23, 93 (1988)
  8. Wilkerson, J Vasc Surg, 11, 567 (1990)
  9. Pate1, SurgClin North Am, 72, 3141 (1992)
  10. Mitsudo Sumi, Brandt Lawrence J., Pathology of Intestinal Ischemia, 10.1016/s0039-6109(16)45627-6
  11. Otamlri, Acta Chir Scand, 153, 51 (1987)
  12. Van Hecke, Magn Reson Imaghg, 9, 313 (1991)
  13. Green, J Lab Clin Med, 111, 173 (1988)
  14. Park, Surgery, 107, 574 (1990)
  15. SPSS for Windows. Base system user's guide, release 6.0. Chicago: SPSS Inc. 1993; 828.
  16. Williamson David F., The Box Plot: A Simple Visual Method to Interpret Data, 10.7326/0003-4819-110-11-916
  17. Brown Rea A., Ultrastructural Changes in the Canine Ileal Mucosal Cell After Mesenteric Arterial Occlusion : A Sequential Study, 10.1001/archsurg.1970.01340260194029
  18. Johnston D. L., Brady T. J., Ratner A. V., Rosen B. R., Newell J. B., Pohost G. M., Okada R. D., Assessment of myocardial ischemia with proton magnetic resonance: effects of a three hour coronary occlusion with and without reperfusion, 10.1161/01.cir.71.3.595
  19. Yu, Invest Radio1, 28, 1015 (1993)
  20. Kim, J Comput Assist Tomogr, 17, 382 (1993)
  21. Saeed M, Wendland M F, Masui T, Connolly A J, Derugin N, Brasch R C, Higgins C B, Myocardial infarction: assessment with an intravascular MR contrast medium. Work in progress., 10.1148/radiology.180.1.2052685
  22. Vexler, J Magn Reson Imaging, 2, 311 (1992)
  23. Schmiedl U, Ogan MD, Moseley ME, Brasch RC, Comparison of the contrast-enhancing properties of albumin-(Gd-DTPA) and Gd-DTPA at 2.0 T: and experimental study in rats, 10.2214/ajr.147.6.1263
  24. Lauffer, Chem Rev, 87, 901 (1987)
Bibliographic reference Van Beers, Bernard ; Mottet, I. ; Delos, Monique ; Goudemant, Jean-François ; Demeure, R. ; et. al. Acute occlusive ischemia of the rat intestine: early detection by MR imaging with polylysine-Gd-DTPA enhancement.. In: Journal of magnetic resonance imaging : JMRI, Vol. 5, no. 5, p. 509-13 (1995)
Permanent URL http://hdl.handle.net/2078.1/13326