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Refinement of 1p36 alterations not involving PRDM16 in myeloid and lymphoid malignancies.

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Duhoux, François [UCL] Ameye, Geneviève Lambot, Virginie Herens, Christian Lambert, Frédéric Poirel, Hélène [UCL]

Fluorescence in situ hybridization was performed to characterize 81 cases of myeloid and lymphoid malignancies with cytogenetic 1p36 alterations not affecting the PRDM16 locus. In total, three subgroups were identified: balanced translocations (N = 27) and telomeric rearrangements (N = 15), both mainly observed in myeloid disorders; and unbalanced non-telomeric rearrangements (N = 39), mainly observed in lymphoid proliferations and frequently associated with a highly complex karyotype. The 1p36 rearrangement was isolated in 12 cases, mainly myeloid disorders. The breakpoints on 1p36 were more widely distributed than previously reported, but with identifiable rare breakpoint cluster regions, such as the TP73 locus. We also found novel partner loci on 1p36 for the known multi-partner genes HMGA2 and RUNX1. We precised the common terminal 1p36 deletion, which has been suggested to have an adverse prognosis, in B-cell lymphomas [follicular lymphomas and diffuse large B-cell lymphomas with t(14;18)(q32;q21) as well as follicular lymphomas without t(14;18)]. Intrachromosomal telomeric repetitive sequences were detected in at least half the cases of telomeric rearrangements. It is unclear how the latter rearrangements occurred and whether they represent oncogenic events or result from chromosomal instability during oncogenesis.

Document type Article de périodique (Journal article) – Article de recherche
Access type Accès libre
Publication date 2011
Language Anglais
Journal information "PloS one" - Vol. 6, no.10, p. e26311 (2011)
Peer reviewed yes
issn 1932-6203
e-issn 1932-6203
Affiliation UCL - SSS/DDUV - Institut de Duve
MESH Subject Cell Line ; Transcription Factors ; Chromosome Aberrations ; Chromosomes, Human, Pair 1 ; DNA-Binding Proteins ; Hematologic Neoplasms ; Humans ; In Situ Hybridization, Fluorescence ; Polymorphism, Single Nucleotide ; Telomere
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Bibliographic reference Duhoux, François ; Ameye, Geneviève ; Lambot, Virginie ; Herens, Christian ; Lambert, Frédéric ; et. al. Refinement of 1p36 alterations not involving PRDM16 in myeloid and lymphoid malignancies.. In: PloS one, Vol. 6, no.10, p. e26311 (2011)
Permanent URL http://hdl.handle.net/2078.1/136679