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EEG frequency-tagging to dissociate the cortical responses to nociceptive and non-nociceptive stimuli.

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Colon, Elisabeth [UCL] Legrain, Valéry [UCL] Mouraux, André [UCL]

Whether the cortical processing of nociceptive input relies on the activity of nociceptive-specific neurons or whether it relies on the activity of neurons also involved in processing non-nociceptive sensory input remains a matter of debate. Here, we combined EEG “frequency-tagging” of steady-state evoked-potentials (SS-EPs) with an intermodal selective attention paradigm to test whether the cortical processing of nociceptive input relies on nociceptive-specific neuronal populations that can be selectively modulated by top-down attention. Trains of nociceptive and vibrotactile stimuli (experiment 1) and trains of nociceptive and visual stimuli (experiment 2) were applied concomitantly to the same hand, thus eliciting nociceptive, vibrotactile and visual SS-EPs. In each experiment, a target detection task was used to focus attention towards one of the two concurrent streams of sensory input. We found that selectively attending to nociceptive or vibrotactile somatosensory input indistinctly enhances the magnitude of nociceptive and vibrotactile SS-EPs, whereas selectively attending to nociceptive or visual input independently enhances the magnitude of the SS-EP elicited by the attended sensory input. This differential effect indicates that the processing of nociceptive input involves neuronal populations also involved in the processing of touch, but distinct from the neuronal populations involved in vision.

Document type Article de périodique (Journal article) – Article de recherche
Publication date 2014
Language Anglais
Journal information "Journal of Cognitive Neuroscience" - Vol. 26, no. 10, p. 2262-2274
Peer reviewed yes
Publisher M I T Press ((United States) Cambridge)
issn 0898-929X
e-issn 1530-8898
Publication status Publié
Affiliation UCL - SSS/IONS/COSY - Systems & cognitive Neuroscience
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Bibliographic reference Colon, Elisabeth ; Legrain, Valéry ; Mouraux, André. EEG frequency-tagging to dissociate the cortical responses to nociceptive and non-nociceptive stimuli.. In: Journal of Cognitive Neuroscience, Vol. 26, no. 10, p. 2262-2274
Permanent URL http://hdl.handle.net/2078.1/141756