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Metastatic signet-ring cell carcinoma of unknown primary origin

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Grégoire, Corinne [UCL] Müller, Gebhard Machiels, Jean-Pascal [UCL] Goeminne, Jean-Charles

About 3-5% of metastatic cancers originate from an unknown primary origin. Some have a signet-ring cell (SRC) component. We report the medical history of three patients with SRC carcinoma expressing both the oestrogen (ER) and progesterone receptors (PR). Although no primary breast cancer could be identified, we considered these three patients as having metastatic breast cancer. All of them were therefore treated with standard breast anti-hormonal therapies and all demonstrated benefit. The pitfalls of clinical presentation, diagnostic work-up, and treatment are discussed.

Document type Article de périodique (Journal article) – Article de recherche
Publication date 2014
Language Anglais
Journal information "Acta Clinica Belgica" - Vol. 69, no.2, p. 135-138 (2014)
Peer reviewed yes
Publisher Maney ((United Kingdom) London)
issn 1784-3286
e-issn 2295-3337
Publication status Publié
Affiliations UCL - SSS/IREC/MIRO - Pôle d'imagerie moléculaire, radiothérapie et oncologie
UCL - (SLuc) Unité d'oncologie médicale
UCL - (SLuc) Centre du cancer
MESH Subject Aged ; Receptors, Progesterone ; Stomach Neoplasms ; Antineoplastic Agents ; Breast Neoplasms ; Carcinoma, Signet Ring Cell ; Female ; Heart Neoplasms ; Humans ; Pleural Neoplasms ; Receptors, Estrogen
Links
  1. DeVita V, Hellman S, Rosenberg S, editors. Cancer: principles and practice of oncology. 5th ed. Philadelphia, PA: Lippincott-Raven; 1997. p. 2423–26.
  2. Boutis Anastasios L, Gastric signet-ring adenocarcinoma presenting with breast metastasis, 10.3748/wjg.v12.i18.2958
  3. Orvieto Enrico, Maiorano Eugenio, Bottiglieri Luca, Maisonneuve Patrick, Rotmensz Nicole, Galimberti Viviana, Luini Alberto, Brenelli Fabricio, Gatti Giovanna, Viale Giuseppe, Clinicopathologic characteristics of invasive lobular carcinoma of the breast : Results of an Analysis of 530 Cases From a Single Institution, 10.1002/cncr.23811
  4. Makino T, Hepatogastroenterology, 53, 845 (2006)
  5. Chu Peiguo G., Weiss Lawrence M., Immunohistochemical Characterization of Signet-Ring Cell Carcinomas of the Stomach, Breast, and Colon, 10.1309/a09erymfr64nerdw
  6. O’Connell FP, Arch Pathol Lab Med, 129, 338 (2005)
  7. Wei Shi, Said-Al-Naief Nasser, Hameed Omar, Estrogen and Progesterone Receptor Expression is not Always Specific for Mammary and Gynecologic Carcinomas : A Tissue Microarray and Pooled Literature Review Study, 10.1097/pai.0b013e31819faa07
  8. Shidham Vinod B, Komorowski Richard A, Machhi Jinobya K, 10.1186/1746-1596-1-34
  9. Mimata Ayako, Fukamachi Hiroshi, Eishi Yoshinobu, Yuasa Yasuhito, Loss of E-cadherin in mouse gastric epithelial cells induces signet ring-like cells, a possible precursor lesion of diffuse gastric cancer, 10.1111/j.1349-7006.2011.01890.x
  10. Schrader K. A., Masciari S., Boyd N., Salamanca C., Senz J., Saunders D. N., Yorida E., Maines-Bandiera S., Kaurah P., Tung N., Robson M. E., Ryan P. D., Olopade O. I., Domchek S. M., Ford J., Isaacs C., Brown P., Balmana J., Razzak A. R., Miron P., Coffey K., Terry M. B., John E. M., Andrulis I. L., Knight J. A., O'Malley F. P., Daly M., Bender P., Moore R., Southey M. C., Hopper J. L., Garber J. E., Huntsman D. G., , Germline mutations in CDH1 are infrequent in women with early-onset or familial lobular breast cancers, 10.1136/jmg.2010.079814
Bibliographic reference Grégoire, Corinne ; Müller, Gebhard ; Machiels, Jean-Pascal ; Goeminne, Jean-Charles. Metastatic signet-ring cell carcinoma of unknown primary origin. In: Acta Clinica Belgica, Vol. 69, no.2, p. 135-138 (2014)
Permanent URL http://hdl.handle.net/2078.1/147202