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Effect of three-drug delivery modalities on Olfactory function in chronic sinusitis

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Reychler, Gregory [UCL] Colbrant, Coralie [UCL] Huart, Caroline [UCL] Le Guellec, Sandrine [Université François Rabelais de Tours] Vecellio, Laurent [Université François Rabelais de Tours] Liistro, Giuseppe [UCL] Rombaux, Philippe [UCL]

Background: Olfactory dysfunction is deemed to be a significant contributor to poor quality of life in chronic rhinosinu-sitis (CRS). Objective: To assess and to compare the effectiveness of three modalities of corticosteroids administration in patients with CRS. Study Design: A prospective randomized controlled study Methods: Thirty patients with CRS were randomized in three groups depending on the route of corticosteroids administration: 16 days by oral route (Medrol (Pfizer, Belgique), 32 mg/8 days-16 mg/4 days-8 mg/4 days); nasal spray (Rhinocort (AstraZeneca, Belgique), 2 × 2 × 64 μg/nostril); or sonic nebulization (Pulmicort (AstraZeneca, Belgique), 2 × 1 mg/4 mL) (Sonic nebulizer, AOHBOX-NL11SN, DTF, France). Olfactory function was assessed using orthonasal threshold discrimination identification and retronasal psychophysical olfactory tests (RNT) before and after the treatment. Same intranasal modalities were previously tested for in vitro airways scintigraphic deposition. Results: In vitro differences in drug deposition pattern between both intranasal modalities were demonstrated. Threshold discrimination identification and RNT were similar between three groups at baseline. Threshold discrimination identification improved by 5.5, 5.8, and -1.1 for sonic nebulization, oral, and nasal spray groups, respectively (P =0.010). This improvement was clinically relevant for oral and nebulized administration. It was similar between oral and nebulized administration but significantly higher than nasal spray administration. Retronasal psychophysical olfactory tests improved similarly for the three groups (P =0.231) Conclusion: Effectiveness of sonic nebulized and oral administration is demonstrated on orthonasal olfactory. The clinical benefit is better than with nasal spray.

Document type Article de périodique (Journal article) – Article de recherche
Access type Accès interdit
Publication date 2015
Language Anglais
Journal information "The Laryngoscope" - Vol. 125, no. 3, p. 549-555 (2014)
Peer reviewed yes
Publisher Wiley-Blackwell ((United States) Philadelphia, PA)
issn 0023-852X
e-issn 1531-4995
Publication status Publié
Affiliations UCL - SSS/IONS/NEUR - Clinical Neuroscience
UCL - SSS/IREC/LUNS - Pôle pneumologie, ORL (airways) et dermatologie (skin)
UCL - (SLuc) Service de pneumologie
UCL - (SLuc) Service d'oto-rhino-laryngologie
Keywords Nebulizer ; Deposition ; Sinus ; Sinusitis
Links
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Bibliographic reference Reychler, Gregory ; Colbrant, Coralie ; Huart, Caroline ; Le Guellec, Sandrine ; Vecellio, Laurent ; et. al. Effect of three-drug delivery modalities on Olfactory function in chronic sinusitis. In: The Laryngoscope, Vol. 125, no. 3, p. 549-555 (2014)
Permanent URL http://hdl.handle.net/2078.1/159825