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Neurobiology of vascular dementia.

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Enciu, Ana-Maria Constantinescu, Stefan N. [UCL] Popescu, Laurenţiu M Mureşanu, Dafin F Popescu, Bogdan O

Vascular dementia is, in its current conceptual form, a distinct type of dementia with a spectrum of specific clinical and pathophysiological features. However, in a very large majority of cases, these alterations occur in an already aged brain, characterized by a milieu of cellular and molecular events common for different neurodegenerative diseases. The cell signaling defects and molecular dyshomeostasis might lead to neuronal malfunction prior to the death of neurons and the alteration of neuronal networks. In the present paper, we explore some of the molecular mechanisms underlying brain malfunction triggered by cerebrovascular disease and risk factors. We suggest that, in the age of genetic investigation and molecular diagnosis, the concept of vascular dementia needs a new approach.

Document type Article de périodique (Journal article)
Access type Accès libre
Publication date 2011
Language Anglais
Journal information "Journal of Aging Research" - Vol. 2011, no.., p. 1-11 (2011)
Peer reviewed yes
Publisher Hindawi Publishing Corporation (New York)
issn 2090-2204
e-issn 2090-2212
Publication status Publié
Affiliation UCL - SSS/DDUV - Institut de Duve
Links
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Bibliographic reference Enciu, Ana-Maria ; Constantinescu, Stefan N. ; Popescu, Laurenţiu M ; Mureşanu, Dafin F ; Popescu, Bogdan O. Neurobiology of vascular dementia.. In: Journal of Aging Research, Vol. 2011, no.., p. 1-11 (2011)
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