User menu

Accès à distance ? S'identifier sur le proxy UCLouvain

Prevalence of alexithymia in patients with psoriasis and its association with disease burden: a multicentre observational study.

Primary tabs

Sampogna, F Puig, L Spuls, P Girolomoni, G Radtke, M A Ghislain, Pierre-Dominique [UCL]

Single-centre studies show that alexithymia, defined as difficulty in recognizing and describing emotions, is more prevalent among patients with psoriasis than in the general population. However, its prevalence and the consequences of the association between alexithymia and psoriasis are unclear. The primary objective of this study was to determine the prevalence of alexithymia, as defined by a score ≥ 61 in the 20-item Toronto Alexithymia Scale, in a large sample of patients who had plaque psoriasis for ≤ 10 years and were eligible for phototherapy or systemic treatment. The secondary objectives were to investigate the relationship between alexithymia and the clinical and psychological aspects of psoriasis. Data were collected in the framework of an observational, multicentre, international study, the EPidemiological Study In Patients With Recently DiagnosEd PSOriasis (EPIDEPSO), aiming at investigating the prevalence of alexithymia and other psychosocial comorbidities in patients with psoriasis of ≤ 10 years' disease duration. The prevalence of alexithymia within a cohort of 670 patients was 24·8% (95% confidence interval 21·7-28·2). Patients with alexithymia had a higher burden of psoriasis, including significant impairment of quality of life, higher levels of anxiety and depression, a higher risk of alcohol dependency and impairment of work productivity, compared with patients without alexithymia. It is important to identify alexithymic patients with psoriasis in clinical practice as they experience a higher disease burden and have a lower ability to express their feelings.

Document type Article de périodique (Journal article) – Article de recherche
Access type Accès restreint
Publication date 2017
Language Anglais
Journal information "British Journal of Dermatology" - Vol. 176, p. 1195-1203 (2017)
Peer reviewed yes
Publisher Wiley-Blackwell Publishing Ltd. (Chichester)
issn 0007-0963
e-issn 1365-2133
Publication status Publié
Affiliation UCL - (SLuc) Service de dermatologie
Links
  1. Gupta Madhulika A, Gupta Aditya K, Psychiatric and Psychological Co-Morbidity in Patients with Dermatologic Disorders : Epidemiology and Management, 10.2165/00128071-200304120-00003
  2. Kurd, Arch Dermatol, 146, 891 (2010)
  3. Sifneos P.E., The Prevalence of ‘Alexithymic’ Characteristics in Psychosomatic Patients, 10.1159/000286529
  4. Nemiah J.C., Sifneos P.E., Psychosomatic Illness: A Problem in Communication, 10.1159/000286074
  5. Taylor, Psychological Mindedness: a Contemporary Understanding, 28 (1997)
  6. Kooiman Cornelis G., van Rees Vellinga Sonja, Spinhoven Philip, Draijer Nel, Trijsburg Rutger W., Rooijmans Harry G.M., Childhood Adversities as Risk Factors for Alexithymia and Other Aspects of Affect Dysregulation in Adulthood, 10.1159/000075542
  7. Picardi Angelo, Pasquini Paolo, Cattaruzza Maria Sofia, Gaetano Paola, Baliva Giannandrea, Melchi Carmelo Franco, Tiago Albertina, Camaioni Diana, Abeni Damiano, Biondi Massimo, Only limited support for a role of psychosomatic factors in psoriasis, 10.1016/s0022-3999(02)00574-3
  8. Cameron Kristjana, Ogrodniczuk John, Hadjipavlou George, Changes in Alexithymia Following Psychological Intervention : A Review, 10.1097/hrp.0000000000000036
  9. Taylor Graeme J., Bagby R. Michael, Parker James D. A., Grotstein James, Disorders of affect regulation : Alexithymia in medical and psychiatric illness, ISBN:9780511526831, 10.1017/cbo9780511526831
  10. Sunay, Psychiatry, 8, 327 (2011)
  11. Cömert Asuman, Akbaş Berfu, Kılıç Emine Zinnur, Akın Özlem, Gökçe Elif, Göktuna Zeynep, Taşkapan Oktay, Psychiatric Comorbidities and Alexithymia in Patients with Seborrheic Dermatitis: A Questionnaire Study in Turkey, 10.1007/s40257-013-0019-7
  12. Sellami Rim, Masmoudi J, Ouali U, Mnif L, Amouri M, Turki H, Jaoua A, The relationship between alopecia areata and alexithymia, anxiety and depression: A case-control study, 10.4103/0019-5154.135525
  13. Willemsen R, Haentjens P, Roseeuw D, Vanderlinden J, Alexithymia in patients with alopecia areata: educational background much more important than traumatic events, 10.1111/j.1468-3083.2009.03255.x
  14. Picardi A., Pasquini P., Cattaruzza M.S., Gaetano P., Baliva G., Melchi C.F., Papi M., Camaioni D., Tiago A., Gobello T., Biondi M., Psychosomatic Factors in First-Onset Alopecia Areata, 10.1176/appi.psy.44.5.374
  15. Masmoudi J., Maalej I., Masmoudi A., Rached H., Rebai A., Turki H., Jaoua A., Alexithymie et psoriasis : étude cas–témoin à propos de 53 patients, 10.1016/j.encep.2007.11.009
  16. Korkoliakou Panagiota, Christodoulou Christos, Kouris Anargyros, Porichi Evgenia, Efstathiou Vasiliki, Kaloudi Eythymia, Kokkevi Anna, Stavrianeas Nikolaos, Papageorgiou Charalabos, Douzenis Athanasios, Alexithymia, anxiety and depression in patients with psoriasis: a case–control study, 10.1186/s12991-014-0038-7
  17. Picardi A., Mazzotti E., Gaetano P., Cattaruzza M.S., Baliva G., Melchi C.F., Biondi M., Pasquini P., Stress, Social Support, Emotional Regulation, and Exacerbation of Diffuse Plaque Psoriasis, 10.1176/appi.psy.46.6.556
  18. Allegranti, Acta Derm Venereol Suppl (Stockh), 186, 146 (1994)
  19. Consoli Silla M., Rolhion Sophie, Martin Caroline, Ruel Karine, Cambazard Frédéric, Pellet Jacques, Misery Laurent, Low Levels of Emotional Awareness Predict a Better Response to Dermatological Treatment in Patients with Psoriasis, 10.1159/000090653
  20. Elise Kleyn C., McKie Shane, Ross Andrew R., Montaldi Daniela, Gregory Lloyd J., Elliott Rebecca, Isaacs Clare L., Anderson Ian M., Richards Helen L., William Deakin J.F., Fortune Donal G., Griffiths Christopher E.M., Diminished Neural and Cognitive Responses to Facial Expressions of Disgust in Patients with Psoriasis: A Functional Magnetic Resonance Imaging Study, 10.1038/jid.2009.152
  21. Leonardi Craig L, Kimball Alexa B, Papp Kim A, Yeilding Newman, Guzzo Cynthia, Wang Yuhua, Li Shu, Dooley Lisa T, Gordon Kenneth B, Efficacy and safety of ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with psoriasis: 76-week results from a randomised, double-blind, placebo-controlled trial (PHOENIX 1), 10.1016/s0140-6736(08)60725-4
  22. Fredriksson T., Pettersson U., Severe Psoriasis – Oral Therapy with a New Retinoid, 10.1159/000250839
  23. Bagby R.Michael, Parker James D.A., Taylor Graeme J., The twenty-item Toronto Alexithymia scale—I. Item selection and cross-validation of the factor structure, 10.1016/0022-3999(94)90005-1
  24. Bagby R.Michael, Taylor Graeme J., Parker James D.A., The twenty-item Toronto Alexithymia scale—II. Convergent, discriminant, and concurrent validity, 10.1016/0022-3999(94)90006-x
  25. FINLAY A.Y., KHAN G.K., Dermatology Life Quality Index (DLQI)-a simple practical measure for routine clinical use, 10.1111/j.1365-2230.1994.tb01167.x
  26. Bjelland Ingvar, Dahl Alv A, Haug Tone Tangen, Neckelmann Dag, The validity of the Hospital Anxiety and Depression Scale, 10.1016/s0022-3999(01)00296-3
  27. Zigmond A. S., Snaith R. P., The Hospital Anxiety and Depression Scale, 10.1111/j.1600-0447.1983.tb09716.x
  28. SAUNDERS JOHN B, AASLAND OLAF G., BABOR THOMAS F., DE LA FUENTE JUAN R., GRANT MARCUS, Development of the Alcohol Use Disorders Identification Test (AUDIT): WHO Collaborative Project on Early Detection of Persons with Harmful Alcohol Consumption-II, 10.1111/j.1360-0443.1993.tb02093.x
  29. Reilly Associates Work Productivity and Activity Impairment Questionnaire: Specific Health Problem 2.0 (WPAI:SHP) http://www.reillyassociates.net/WPAI_SHP.html
  30. Reilly Margaret C., Zbrozek Arthur S., Dukes Ellen M., The Validity and Reproducibility of a Work Productivity and Activity Impairment Instrument : , 10.2165/00019053-199304050-00006
  31. Richards Helen L., Fortune Dónal G., Griffiths Christopher E.M., Main Chris J., Alexithymia in patients with psoriasis, 10.1016/j.jpsychores.2004.03.009
  32. Rubino, Acta Derm Venereol Suppl (Stockh), 146, 87 (1989)
  33. Kokkonen Pirkko, Karvonen Juha T., Veijola Juha, Läksy Kristian, Jokelainen Jari, Järvelin Marjo-Riitta, Joukamaa Matti, Prevalence and sociodemographic correlates of alexithymia in a population sample of young adults, 10.1053/comp.2001.27892
  34. Mattila Aino K., Salminen Jouko K., Nummi Tapio, Joukamaa Matti, Age is strongly associated with alexithymia in the general population, 10.1016/j.jpsychores.2006.04.013
  35. Franz Matthias, Popp Kerstin, Schaefer Ralf, Sitte Wolfgang, Schneider Christine, Hardt Jochen, Decker Oliver, Braehler Elmar, Alexithymia in the German general population, 10.1007/s00127-007-0265-1
  36. Alexithymia: past and present, 10.1176/ajp.153.7.137
  37. Alexithymia: concept, measurement, and implications for treatment, 10.1176/ajp.141.6.725
  38. Martin John B., Pihl R.O., The Stress-Alexithymia Hypothesis: Theoretical and Empirical Considerations, 10.1159/000287876
  39. Tolmunen Tommi, Heliste Maria, Lehto Soili M., Hintikka Jukka, Honkalampi Kirsi, Kauhanen Jussi, Stability of alexithymia in the general population: an 11-year follow-up, 10.1016/j.comppsych.2010.09.007
  40. Salminen J.K., Saarijärvi S., Toikka T., Kauhanen J., Äärelä E., Alexithymia behaves as a personality trait over a 5-year period in Finnish general population, 10.1016/j.jpsychores.2006.01.014
  41. de Haan Hein, Joosten Evelien, Wijdeveld Toon, Boswinkel Peter, van der Palen Job, De Jong Cor, Alexithymia is not a stable personality trait in patients with substance use disorders, 10.1016/j.psychres.2011.09.027
  42. Kimball, J Eur Acad Dermatol Venereol, 24, 989 (2010)
  43. Lebwohl Mark G., Bachelez Hervé, Barker Jonathan, Girolomoni Giampiero, Kavanaugh Arthur, Langley Richard G., Paul Carle F., Puig Lluís, Reich Kristian, van de Kerkhof Peter C.M., Patient perspectives in the management of psoriasis: Results from the population-based Multinational Assessment of Psoriasis and Psoriatic Arthritis Survey, 10.1016/j.jaad.2013.12.018
  44. Maza A., Richard M.A., Aubin F., Ortonne J.P., Prey S., Bachelez H., Beylot-Barry M., Bulai-Livideanu C., Lahfa M., Nougué J., Mengual X., Le Moigne M., Lauwers-Cances V., Paul C., Significant delay in the introduction of systemic treatment of moderate to severe psoriasis: a prospective multicentre observational study in outpatients from hospital dermatology departments in France : Delays in the systemic treatment of moderate to severe psoriasis, 10.1111/j.1365-2133.2012.10991.x
  45. Marchesi C, Brusamonti E, Maggini C, Are alexithymia, depression, and anxiety distinct constructs in affective disorders?, 10.1016/s0022-3999(00)00084-2
  46. Thorberg Fred Arne, Young Ross McD., Sullivan Karen A., Lyvers Michael, Alexithymia and alcohol use disorders: A critical review, 10.1016/j.addbeh.2008.10.016
  47. Naldi Luigi, Scoring and monitoring the severity of psoriasis. What is the preferred method? What is the ideal method? Is PASI passé? facts and controversies, 10.1016/j.clindermatol.2009.03.001
  48. Sampogna Francesca, Sera Francesco, Abeni Damiano, Measures of Clinical Severity, Quality of Life, and Psychological Distress in Patients with Psoriasis: A Cluster Analysis, 10.1046/j.0022-202x.2003.09101.x
  49. Ayala F., Sampogna F., Romano G.V., Merolla R., Guida G., Gualberti G., Paparatti U.d.L., Amerio P., Balato N., Potenza C., , The impact of psoriasis on work-related problems: a multicenter cross-sectional survey, 10.1111/jdv.12233
Bibliographic reference Sampogna, F ; Puig, L ; Spuls, P ; Girolomoni, G ; Radtke, M A ; et. al. Prevalence of alexithymia in patients with psoriasis and its association with disease burden: a multicentre observational study.. In: British Journal of Dermatology, Vol. 176, p. 1195-1203 (2017)
Permanent URL http://hdl.handle.net/2078.1/192826