Diman, Aurélie
Decottignies, Anabelle
Long noncoding RNAs, produced from distinct regions of the chromosomes, are emerging as new key players in several important biological processes. The long noncoding RNAs add a new layer of complexity to cellular regulatory pathways, from transcription to cellular trafficking or chromatin remodeling. More than 25 years ago, the discovery of a transcriptional activity at telomeres of protozoa ended the long-lasting belief that telomeres were transcriptionally silent. Since then, progressively accumulating evidences established that production of TElomeric Repeat-containing RNA (TERRA) was a general feature of eukaryotic cells. Whether TERRA molecules always originate from the telomeres or whether they can be transcribed from internal telomeric repeats as well is however still a matter of debate. Whether TERRA transcripts always localize to telomeres and play similar roles in all eukaryotic cells is also unclear. We review the studies on TERRA localization in the cell, its composition and some aspects of its transcriptional regulation to summarize the current knowledge and controversies about the genomic origin of TERRA, with a focus on human and mouse TERRA.
- Rudenko, EMBO J, 8, 2633 (1989)
- Solovei I., Gaginskaya E. R., Macgregor H. C., The arrangement and transcription of telomere DNA sequences at the ends of lampbrush chromosomes of birds, 10.1007/bf01552869
- Azzalin C. M., Reichenbach P., Khoriauli L., Giulotto E., Lingner J., Telomeric Repeat Containing RNA and RNA Surveillance Factors at Mammalian Chromosome Ends, 10.1126/science.1147182
- Schoeftner Stefan, Blasco Maria A., Developmentally regulated transcription of mammalian telomeres by DNA-dependent RNA polymerase II, 10.1038/ncb1685
- Luke Brian, Panza Andrea, Redon Sophie, Iglesias Nahid, Li Zhijian, Lingner Joachim, The Rat1p 5′ to 3′ Exonuclease Degrades Telomeric Repeat-Containing RNA and Promotes Telomere Elongation in Saccharomyces cerevisiae, 10.1016/j.molcel.2008.10.019
- Bah Amadou, Wischnewski Harry, Shchepachev Vadim, Azzalin Claus M., The telomeric transcriptome of Schizosaccharomyces pombe, 10.1093/nar/gkr1153
- Greenwood Jessica, Cooper Julia Promisel, Non-coding telomeric and subtelomeric transcripts are differentially regulated by telomeric and heterochromatin assembly factors in fission yeast, 10.1093/nar/gkr1155
- Vrbsky Jan, Akimcheva Svetlana, Watson J. Matthew, Turner Thomas L., Daxinger Lucia, Vyskot Boris, Aufsatz Werner, Riha Karel, siRNA–Mediated Methylation of Arabidopsis Telomeres, 10.1371/journal.pgen.1000986
- Cusanelli Emilio, Chartrand Pascal, Telomeric repeat-containing RNA TERRA: a noncoding RNA connecting telomere biology to genome integrity, 10.3389/fgene.2015.00143
- de Silanes Isabel López, Graña Osvaldo, De Bonis Maria Luigia, Dominguez Orlando, Pisano David G, Blasco Maria A, Identification of TERRA locus unveils a telomere protection role through association to nearly all chromosomes, 10.1038/ncomms5723
- Chu Hsueh-Ping, Froberg John E, Kesner Barry, Oh Hyun Jung, Ji Fei, Sadreyev Ruslan, Pinter Stefan F, Lee Jeannie T, PAR-TERRA directs homologous sex chromosome pairing, 10.1038/nsmb.3432
- Chu Hsueh-Ping, Cifuentes-Rojas Catherine, Kesner Barry, Aeby Eric, Lee Hun-goo, Wei Chunyao, Oh Hyun Jung, Boukhali Myriam, Haas Wilhelm, Lee Jeannie T., TERRA RNA Antagonizes ATRX and Protects Telomeres, 10.1016/j.cell.2017.06.017
- Diman A., Boros J., Poulain F., Rodriguez J., Purnelle M., Episkopou H., Bertrand L., Francaux M., Deldicque L., Decottignies A., Nuclear respiratory factor 1 and endurance exercise promote human telomere transcription, 10.1126/sciadv.1600031
- Nergadze S. G., Farnung B. O., Wischnewski H., Khoriauli L., Vitelli V., Chawla R., Giulotto E., Azzalin C. M., CpG-island promoters drive transcription of human telomeres, 10.1261/rna.1748309
- Porro Antonio, Feuerhahn Sascha, Delafontaine Julien, Riethman Harold, Rougemont Jacques, Lingner Joachim, Functional characterization of the TERRA transcriptome at damaged telomeres, 10.1038/ncomms6379
- Feretzaki Marianna, Lingner Joachim, A practical qPCR approach to detect TERRA, the elusive telomeric repeat-containing RNA, 10.1016/j.ymeth.2016.08.004
- Deng Zhong, Wang Zhuo, Stong Nick, Plasschaert Robert, Moczan Aliah, Chen Horng-Shen, Hu Sufeng, Wikramasinghe Priyankara, Davuluri Ramana V, Bartolomei Marisa S, Riethman Harold, Lieberman Paul M, A role for CTCF and cohesin in subtelomere chromatin organization, TERRA transcription, and telomere end protection : Chromatin organization of human subtelomeres, 10.1038/emboj.2012.266
- Brown William R.A., MacKinnon Philip J., Villasanté Alfredo, Spurr Nigel, Buckle Veronica J., Dobson Melanie J., Structure and polymorphism of human telomere-associated DNA, 10.1016/0092-8674(90)90293-n
- Montero Juan José, López de Silanes Isabel, Graña Osvaldo, Blasco Maria A., Telomeric RNAs are essential to maintain telomeres, 10.1038/ncomms12534
- Episkopou Harikleia, Draskovic Irena, Van Beneden Amandine, Tilman Gaëlle, Mattiussi Marina, Gobin Matthieu, Arnoult Nausica, Londoño-Vallejo Arturo, Decottignies Anabelle, Alternative Lengthening of Telomeres is characterized by reduced compaction of telomeric chromatin, 10.1093/nar/gku114
- Ng Laura J., Cropley Jennifer E., Pickett Hilda A., Reddel Roger R., Suter Catherine M., Telomerase activity is associated with an increase in DNA methylation at the proximal subtelomere and a reduction in telomeric transcription, 10.1093/nar/gkn1030
- Yehezkel Shiran, Segev Yardena, Viegas-Péquignot Evani, Skorecki Karl, Selig Sara, Hypomethylation of subtelomeric regions in ICF syndrome is associated with abnormally short telomeres and enhanced transcription from telomeric regions, 10.1093/hmg/ddn177
- Arnoult Nausica, Van Beneden Amandine, Decottignies Anabelle, Telomere length regulates TERRA levels through increased trimethylation of telomeric H3K9 and HP1α, 10.1038/nsmb.2364
- Beneden, Front Oncol, 3, 178 (2013)
- Porro A., Feuerhahn S., Reichenbach P., Lingner J., Molecular Dissection of Telomeric Repeat-Containing RNA Biogenesis Unveils the Presence of Distinct and Multiple Regulatory Pathways, 10.1128/mcb.00460-10
- Tutton S., Azzam G. A., Stong N., Vladimirova O., Wiedmer A., Monteith J. A., Beishline K., Wang Z., Deng Z., Riethman H., McMahon S. B., Murphy M., Lieberman P. M., Subtelomeric p53 binding prevents accumulation of DNA damage at human telomeres, 10.15252/embj.201490880
- Arora Rajika, Lee Yongwoo, Wischnewski Harry, Brun Catherine M., Schwarz Tobias, Azzalin Claus M., RNaseH1 regulates TERRA-telomeric DNA hybrids and telomere maintenance in ALT tumour cells, 10.1038/ncomms6220
- Sagie Shira, Toubiana Shir, Hartono Stella R., Katzir Hagar, Tzur-Gilat Aya, Havazelet Shany, Francastel Claire, Velasco Guillaume, Chédin Frédéric, Selig Sara, Telomeres in ICF syndrome cells are vulnerable to DNA damage due to elevated DNA:RNA hybrids, 10.1038/ncomms14015
- Clynes David, Jelinska Clare, Xella Barbara, Ayyub Helena, Scott Caroline, Mitson Matthew, Taylor Stephen, Higgs Douglas R., Gibbons Richard J., Suppression of the alternative lengthening of telomere pathway by the chromatin remodelling factor ATRX, 10.1038/ncomms8538
- Eid Rita, Demattei Marie-Véronique, Episkopou Harikleia, Augé-Gouillou Corinne, Decottignies Anabelle, Grandin Nathalie, Charbonneau Michel, Genetic Inactivation ofATRXLeads to a Decrease in the Amount of Telomeric Cohesin and Level of Telomere Transcription in Human Glioma Cells, 10.1128/mcb.01317-14
- Zhang L.-F., Ogawa Y., Ahn J. Y., Namekawa S. H., Silva S. S., Lee J. T., Telomeric RNAs Mark Sex Chromosomes in Stem Cells, 10.1534/genetics.109.103093
- Schoeftner S., Blanco R., de Silanes I. L., Munoz P., Gomez-Lopez G., Flores J. M., Blasco M. A., Telomere shortening relaxes X chromosome inactivation and forces global transcriptome alterations, 10.1073/pnas.0909265106
- Deng Z., Wang Z., Xiang C., Molczan A., Baubet V., Conejo-Garcia J., Xu X., Lieberman P. M., Dahmane N., Formation of telomeric repeat-containing RNA (TERRA) foci in highly proliferating mouse cerebellar neuronal progenitors and medulloblastoma, 10.1242/jcs.108118
- Goldberg Aaron D., Banaszynski Laura A., Noh Kyung-Min, Lewis Peter W., Elsaesser Simon J., Stadler Sonja, Dewell Scott, Law Martin, Guo Xingyi, Li Xuan, Wen Duancheng, Chapgier Ariane, DeKelver Russell C., Miller Jeffrey C., Lee Ya-Li, Boydston Elizabeth A., Holmes Michael C., Gregory Philip D., Greally John M., Rafii Shahin, Yang Chingwen, Scambler Peter J., Garrick David, Gibbons Richard J., Higgs Douglas R., Cristea Ileana M., Urnov Fyodor D., Zheng Deyou, Allis C. David, Distinct Factors Control Histone Variant H3.3 Localization at Specific Genomic Regions, 10.1016/j.cell.2010.01.003
- Pfeiffer Verena, Lingner Joachim, TERRA Promotes Telomere Shortening through Exonuclease 1–Mediated Resection of Chromosome Ends, 10.1371/journal.pgen.1002747
- Iglesias Nahid, Redon Sophie, Pfeiffer Verena, Dees Martina, Lingner Joachim, Luke Brian, Subtelomeric repetitive elements determine TERRA regulation by Rap1/Rif and Rap1/Sir complexes in yeast, 10.1038/embor.2011.73
- Balk Bettina, Maicher André, Dees Martina, Klermund Julia, Luke-Glaser Sarah, Bender Katharina, Luke Brian, Telomeric RNA-DNA hybrids affect telomere-length dynamics and senescence, 10.1038/nsmb.2662
- Pfeiffer Verena, Crittin Jérôme, Grolimund Larissa, Lingner Joachim, The THO complex component Thp2 counteracts telomeric R-loops and telomere shortening, 10.1038/emboj.2013.217
- Graf Marco, Bonetti Diego, Lockhart Arianna, Serhal Kamar, Kellner Vanessa, Maicher André, Jolivet Pascale, Teixeira Maria Teresa, Luke Brian, Telomere Length Determines TERRA and R-Loop Regulation through the Cell Cycle, 10.1016/j.cell.2017.06.006
- Cusanelli Emilio, Romero Carmina Angelica Perez, Chartrand Pascal, Telomeric Noncoding RNA TERRA Is Induced by Telomere Shortening to Nucleate Telomerase Molecules at Short Telomeres, 10.1016/j.molcel.2013.08.029
- Moravec Martin, Wischnewski Harry, Bah Amadou, Hu Yan, Liu Na, Lafranchi Lorenzo, King Megan C, Azzalin Claus M, TERRA promotes telomerase‐mediated telomere elongation inSchizosaccharomyces pombe, 10.15252/embr.201541708
- Nanavaty Vishal, Sandhu Ranjodh, Jehi Sanaa E., Pandya Unnati M., Li Bibo,
Trypanosoma brucei RAP1 maintains telomere and subtelomere integrity by suppressing TERRA and telomeric RNA:DNA hybrids, 10.1093/nar/gkx184
- García-Cao Marta, O'Sullivan Roderick, Peters Antoine H F M, Jenuwein Thomas, Blasco María A, Epigenetic regulation of telomere length in mammalian cells by the Suv39h1 and Suv39h2 histone methyltransferases, 10.1038/ng1278
- Rosenfeld Jeffrey A, Wang Zhibin, Schones Dustin E, Zhao Keji, DeSalle Rob, Zhang Michael Q, Determination of enriched histone modifications in non-genic portions of the human genome, 10.1186/1471-2164-10-143
- O'Sullivan Roderick J, Kubicek Stefan, Schreiber Stuart L, Karlseder Jan, Reduced histone biosynthesis and chromatin changes arising from a damage signal at telomeres, 10.1038/nsmb.1897
- Guenatri Mounia, Bailly Delphine, Maison Christèle, Almouzni Geneviève, Mouse centric and pericentric satellite repeats form distinct functional heterochromatin, 10.1083/jcb.200403109
- López de Silanes, Nat Comm, 1, 33 (2010)
- Hirashima Kyotaro, Seimiya Hiroyuki, Telomeric repeat-containing RNA/G-quadruplex-forming sequences cause genome-wide alteration of gene expression in human cancer cells in vivo, 10.1093/nar/gkv063
- Robin Jérôme D., Ludlow Andrew T., Batten Kimberly, Magdinier Frédérique, Stadler Guido, Wagner Kathyrin R., Shay Jerry W., Wright Woodring E., Telomere position effect: regulation of gene expression with progressive telomere shortening over long distances, 10.1101/gad.251041.114
- Robin Jérôme D., Ludlow Andrew T., Batten Kimberly, Gaillard Marie-Cécile, Stadler Guido, Magdinier Frédérique, Wright Woodring E., Shay Jerry W., SORBS2transcription is activated by telomere position effect–over long distance upon telomere shortening in muscle cells from patients with facioscapulohumeral dystrophy, 10.1101/gr.190660.115
- Kim Wanil, Ludlow Andrew T., Min Jaewon, Robin Jerome D., Stadler Guido, Mender Ilgen, Lai Tsung-Po, Zhang Ning, Wright Woodring E., Shay Jerry W., Regulation of the Human Telomerase Gene TERT by Telomere Position Effect—Over Long Distances (TPE-OLD): Implications for Aging and Cancer, 10.1371/journal.pbio.2000016
Bibliographic reference |
Diman, Aurélie ; Decottignies, Anabelle. Genomic origin and nuclear localization of TERRA telomeric repeat-containing RNA: from Darkness to Dawn.. In: FEBS Journal, Vol. 10.1111/febs.14363, p. 10.1111/febs.14363 (2017) |
Permanent URL |
http://hdl.handle.net/2078.1/194114 |