Braquet, P.
Senn, N.
Robin, J P
Esanu, A.
Godfraind, Theophile
[UCL]
Garay, R.
Several mammalian lignans, particularly enterolactone, 3-oxy-methyl enterolactone and prestegane B are able to inhibit Na+, K+-pump activity in human red cells with IC50 of about 1 mM. The inhibition of Na+, K+-pump activity by mammalian lignans have the following properties: the IC50 for ouabain remains unchanged suggesting a noncompetitive inhibition. The apparent affinity for internal Na+ and maximal rate of cation translocation are both diminished. The above inhibition of the Na+, K+-pump was obtained at doses 2-3 orders of magnitude higher than those required for ouabain. However we cannot exclude that a glycosyl- (and/or butenolide)-derivative of enterolactone could be one endogenous ouabain-like factor.
Bibliographic reference |
Braquet, P. ; Senn, N. ; Robin, J P ; Esanu, A. ; Godfraind, Theophile ; et. al. Inhibition of the erythrocyte Na+, K+-pump by mammalian lignans.. In: Pharmacological research communications, Vol. 18, no. 3, p. 227-39 (1986) |
Permanent URL |
http://hdl.handle.net/2078.1/21792 |